Response to referee 2 comments on “A remote sensing-based dataset to characterize the ecosystem functioning and functional diversity of a Biosphere Reserve: Sierra Nevada (SE Spain)” by Beatriz P. Cazorla et al.

Cazorla, Beatriz P.

doi:10.5194/essd-2019-198-ac2

Cited by 2 publications

(2 citation statements)

References 8 publications

(8 reference statements)

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“…The ligand selectivity of p75 appears to be dependent on the cell type; for example, in sympathetic neurones, it binds neurotrophin-3 (NTF3, P20783) with comparable affinity to trkC [44]. Small molecule agonists of trkB have been described, including LM22A4 [148], while ANA12 has been described as a noncompetitive antagonist of BDNF binding to trkB [27]. GNF5837 is a family-selective tyrosine kinase inhibitor [2], while the tyrosine kinase activity of the trkA receptor can be inhibited by GW441756 (pIC = 8.7, […”

Section: Type V Rtks: Fgf (Fibroblast Growth Factor) Receptor Familymentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors

Alexander

Fabbro

Kelly

et al. 2019

British J Pharmacology

199

208

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The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (http://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14751. Catalytic receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ion channels, nuclear hormone receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

show abstract

Section: Type V Rtks: Fgf (Fibroblast Growth Factor) Receptor Familymentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors

Alexander

Fabbro

Kelly

et al. 2019

British J Pharmacology

199

208

View full text Add to dashboard Cite

show abstract

“…The ligand selectivity of p75 appears to be dependent on the cell type; for example, in sympathetic neu-rones, it binds neurotrophin-3 (NTF3, P20783) with comparable affinity to trkC [46]. Small molecule agonists of trkB have been described, including LM22A4 [160], while ANA12 has been described as a non-com-petitive antagonist of BDNF binding to trkB [29]. GNF5837 is a family-selective tyrosine kinase inhibitor [2], while the tyrosine kinase activity of the trkA receptor can be inhibited by GW441756 (pIC 50 = 8.7, [257]) and tyrphostin AG879 [181].…”

Section: Nomenclaturementioning

confidence: 99%

The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors

Alexander,

Fabbro,

Kelly

et al. 2023

British J Pharmacology

View full text Add to dashboard Cite

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16180. Catalytic receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ion channels, nuclear hormone receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

show abstract

Response to referee 2 comments on “A remote sensing-based dataset to characterize the ecosystem functioning and functional diversity of a Biosphere Reserve: Sierra Nevada (SE Spain)” by Beatriz P. Cazorla et al.

Cited by 2 publications

References 8 publications

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors

The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors

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