Response to radiotherapy of head and neck tumors in AIDS patients

Hommel, Daniel J.; Brown, Michael L.; Kinzie, Jeannie J.

doi:10.1016/0002-9610(89)90021-4

Cited by 26 publications

(3 citation statements)

References 25 publications

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“…Oral non-Hodgkin's lymphoma typically presenting as a rapidly growing mass or ulcer in the gingiva (Fig. 41,or fauces,or tooth mobility (22,27,44,84,87,96,111,116,118,128,145,184,219). Biopsy is needed to confirm the diagnosis.…”

Section: Epstein-bar Virusmentioning

confidence: 99%

Infectious and tropical diseases affecting the human mouth

Scully¹,

Monteil²,

Sposto³

1998

Periodontology 2000

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Section: Epstein-bar Virusmentioning

confidence: 99%

Infectious and tropical diseases affecting the human mouth

Scully¹,

Monteil²,

Sposto³

1998

Periodontology 2000

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“…Furthermore, radiotherapy produces only local control, with both central and marginal recurrences at the field site of treatment. 7 Single (multiple) chemotherapy has demonstrated partial or no response because EKS lesions are more extensive, infiltrative, and rapidly progressive than classic KS. Although zidovudine (AZT) has shown some antiviral effectiveness with improvement in short-term AIDS survival, 95% of AIDS-treated patients relapse while under treatment and die of opportunistic bacterial, fungal, and viral infections.…”

Section: Subtypesmentioning

confidence: 99%

Photodynamic Therapy for Treatment of AIDS‐Related Oral Kaposi's Sarcoma

Schweitzer

Visscher

1990

Otolaryngol.--head neck surg.

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Since 1975, Phase I and II studies have demonstrated the successfulness of hematoporphyrin derivative photodynamic therapy in the treatment of various malignancies of the skin, eye, bladder, lung, and head and neck. Moreover, two cases of traditional Western cutaneous Kaposi's sarcoma (TKS) have been treated with photodynamic therapy with both early and late complete response. To date, attempts at cure and palliation of the more aggressive AIDS-related oral Kaposi's sarcoma with conventional radiation, chemotherapy or immunotherapy, or surgical excision have been limited and often associated with debilitating mucositis and further immunosuppression. Certain aspects of photodynamic therapy may be efficacious for treatment of Kaposi's sarcoma: (1) the selective retention of hematoporphyrin derivative by neoplastic lesions; (2) a tumor-specific cytotoxic agent (i.e., free oxygen radical); (3) absence of systemic toxicity from immunosuppression; and (4) the potential for retreatment without increasing side effects. Herein we present five cases of AIDS-related KS (EKS) with diffuse, superficial, and nodular oral lesions treated with dihematoporphyrin derivative and photodynamic therapy with subsequent dramatic early partial and complete responses.

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“…Similarly, malignancies of the thyroid and major salivary gland act differently to HNSCC. Previously, head and neck cancer treatments were primarily limited to surgeons and radiation oncologists ( 28 , 29 ). However, advancements in medical knowledge and technology have expanded the range of specialists involved in managing this condition over time.…”

Section: Introductionmentioning

confidence: 99%

Expanding the role of combined immunochemotherapy and immunoradiotherapy in the management of head and neck cancer (Review)

Wei,

Lan,

Qiu

et al. 2023

Oncol Lett

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Immunotherapy has become one of the most promising approaches in tumor therapy, and there are numerous associated clinical trials in China. As an immunosuppressive tumor, head and neck squamous cell carcinoma (HNSCC) carries a high mutation burden, making immune checkpoint inhibitors promising candidates in this field due to their unique mechanism of action. The present review outlines a comprehensive multidisciplinary cancer treatment approach and elaborates on how combining immunochemotherapy and immunoradiotherapy guidelines could enhance clinical efficacy in patients with HNSCC. Furthermore, the present review explores the immunology of HNSCC, current immunotherapeutic strategies to enhance antitumor activity, ongoing clinical trials and the future direction of the current immune landscape in HNSCC. Advanced-stage HNSCC presents with a poor prognosis, low survival rates and minimal improvement in patient survival trends over time. Understanding the potential of immunotherapy and ways to combine it with surgery, chemotherapy and radiotherapy confers good prospects for the management of human papillomavirus (HPV)-positive HNSCC, as well as other HPV-positive malignancies. Understanding the immune system and its effect on HNSCC progression and metastasis will help to uncover novel biomarkers for the selection of patients and to enhance the efficacy of treatments. Further research on why current immune checkpoint inhibitors and targeted drugs are only effective for some patients in the clinic is needed; therefore, further research is required to improve the overall survival of affected patients.

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Response to radiotherapy of head and neck tumors in AIDS patients

Cited by 26 publications

References 25 publications

Infectious and tropical diseases affecting the human mouth

Infectious and tropical diseases affecting the human mouth

Photodynamic Therapy for Treatment of AIDS‐Related Oral Kaposi's Sarcoma

Expanding the role of combined immunochemotherapy and immunoradiotherapy in the management of head and neck cancer (Review)

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