Response to radioembolization with yttrium-90 resin microspheres may allow surgical treatment with curative intent and prolonged survival in previously unresectable hepatocellular carcinoma

Treatment of Hepatocellular Cancer Due to Hepatitis Delta with Yttrium-90 Radioembolization in a Patient with Cirrhosis: A Case Report

“…The overall survival without tumors after transplantation in patients who are administered a successful regression therapy is as excellent as in patients meeting the required criteria (16,17). our patient had hCC indicating lesions of 2 cm in the cirrhotic segment 7 cm and 6 cm in segment 6 of the liver detected by MRI and he was at the limit with respect to the Milan criteria, but he had no donor for immediate transplantation.…”

Bridging and downstaging therapy in patients suffering from hepatocellular carcinoma waiting on the list of liver transplantation

“…There are limited papers describing downstaging of HCC by means of TARE (96,98,100,101). Downstaging of the tumor had been observed in the rate of around 37% without significant difference as compare to TACE, while the recurrence rate is 26% (102).…”

“…The highly concentrated radioactive substance would be administrated to the tumor, while keeping the level of toxicity affecting the functional liver parenchyma at the minimal and preserving the blood supply (94,95). It was also safe for use in patients with portal vein thrombosis (96).…”

Commentary on the article entitled “hepatocellular carcinoma with macrovascular invasion treated with yttrium-90 radioembolization prior to transplantation”

“…Between 50% to 70% of patients with hepatocellular carcinoma (HCC) are diagnosed at a stage when radical treatment (percutaneous ablation, partial hepatectomy, liver transplantation) are no longer an option (1). Limitations due to size, number and location of tumours, as well as quantity and quality of liver remnant, prohibit partial hepatectomy.…”

“…Liver transplantation removes not only the tumour, but replaces the underlying cirrhotic liver with a normal liver. It is not surprising that liver transplantation offers the best overall and tumour-free survival in selected patients (1,2).…”