Response to postoperative radiotherapy as a prognostic factor for patients with low-grade gliomas

Spych, Michał; Gottwald, Leszek; Jesień-Lewandowicz, Emilia; Sztajer, Sławomir; Fijuth, Jacek

doi:10.3892/ol.2012.759

Cited by 5 publications

(6 citation statements)

References 29 publications

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“…LGGs treated with postoperative RT which was highly correlated with overall survival 3,9 in prior studies, whereas other studies reported that postoperative RT was no statistically significant difference in survival was seen between the postoperative RT and non-RT groups. 2,8,26 However, the heterogeneity of the study population of LGGs was observed in previous studies.…”

Section: Discussionmentioning

confidence: 81%

“…Overall median survival time have been reported between 3.9 and 10.8 years in the LGG which composed of astrocytomas, oligodendrogliomas, and mixed oligoastrocytomas. [1][2][3][4][5][6] Spych et al reported LGG had the median survival times of 26.9 months (range: 25.4-46.8 months), whereas the median survival times was 48 months (range: 30 months-138 months) according to the study by Kumthekar et al 2,3 Moreover, The 1-year, 3-year, and 5-year overall survivals of LGG were 88.3, 55.1, and 43.3%, respectively. 2 As the present results, the prognosis of our cohort was poorer than prior studies that the median survival time of the cohort was 26 months and the 5-year probability was 22.0%.…”

Section: Discussionmentioning

confidence: 99%

“…DA is a relatively slow-growing brain tumor with a median survival time of 3.9 to 10.8 years. [1][2][3][4][5][6] However, DA infiltrates brain parenchyma, making it hard for total resection. The rate of gross-total resection is only 14 to 17%.…”

Section: Introductionmentioning

confidence: 99%

“…The rate of gross-total resection is only 14 to 17%. 2,3 Therefore, residual tumors become the burden of patients with DA in the long-term follow-up.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Factors and Nomogram Predicting Survival in Diffuse Astrocytoma

Tunthanathip

Ratanalert

Saeheng

et al. 2020

JNRP

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Background Prognosis of low-grade glioma are currently determined by genetic markers that are limited in some countries. This study aimed to use clinical parameters to develop a nomogram to predict survival of patients with diffuse astrocytoma (DA) which is the most common type of low-grade glioma. Materials and Methods Retrospective data of adult patients with DA from three university hospitals in Thailand were analyzed. Collected data included clinical characteristics, neuroimaging findings, treatment, and outcomes. Cox's regression analyses were performed to determine associated factors. Significant associated factors from the Cox regression model were subsequently used to develop a nomogram for survival prediction. Performance of the nomogram was then tested for its accuracy. Results There were 64 patients with DA with a median age of 39.5 (interquartile range [IQR] = 20.2) years. Mean follow-up time of patients was 42 months (standard deviation [SD] = 34.3). After adjusted for three significant factors associated with survival were age ≥60 years (hazard ratio [HR] = 5.8; 95% confidence interval [CI]: 2.09-15.91), motor response score of Glasgow coma scale < 6 (HR = 75.5; 95% CI: 4.15-1,369.4), and biopsy (HR = 0.45; 95% CI: 0.21-0.92). To predict 1-year mortality, sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and area under the curve our nomogram was 1.0, 0.50, 0.45, 1.0, 0.64, and 0.75, respectively. Conclusions This study provided a nomogram predicting prognosis of DA. The nomogram showed an acceptable performance for predicting 1-year mortality. AbstractKeywords ► diffuse astrocytoma ► nomogram ► survival analysis

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The rate of gross-total resection is only 14 to 17%. 2,3 Therefore, residual tumors become the burden of patients with DA in the long-term follow-up.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Factors and Nomogram Predicting Survival in Diffuse Astrocytoma

Tunthanathip

Ratanalert

Saeheng

et al. 2020

JNRP

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“…Кроме этого, судорожный контроль был лучше при назначении послеоперационной ЛТ (75% против 59%, р=0,03) [26]. Ответ на ЛТ после неполной резекции опухоли являлся строгим предиктором выживаемости (р<0,0001) [27] [30].…”

Section: подходы к лечению гнсз лучевая терапияunclassified

Prognostic factors for low-grade diffuse gliomas and approaches to their treatment

Borisov¹,

Sakayeva²

2015

Onkol. Z. im. P.A. Gercena

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В обзоре рассмотрена роль прогностических факторов при глиомах низкой степени злокачественности у взрослых пациентов. Оценено влияние морфологии опухоли, ее размера и объема резекции на выживаемость пациентов. Представлены данные об эффективности лучевой терапии, химиотерапии и комбинированного лечения. Ключевые слова: диффузные глиомы низкой степени злокачественности, взрослые пациенты, прогностические факторы, лучевая терапия, химиотерапия. The literature review examines the role of prognostic factors in low-grade gliomas in adults. The influence of the morphology of the tumor, its size and volume of resection on survival of patients is evaluated. The data on the effectiveness of radiotherapy, chemotherapy and combined treatment are presented.

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