Response to Parenteral Triamcinolone in Severe Asthma: A Useful Induced Phenotype for Clinicians?

Calhoun, William J.; Villasante‐Tezanos, Alejandro

doi:10.1164/rccm.202012-4485ed

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Exacerbations Accelerate a Loss Of Lung Function1

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2022

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Cited by 2 publications

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“…To gain further insight into patterns of exacerbation-associated altered lung function, SARP individuals were given a single 40 mg injectable dose of triamcinolone [24 ▪▪ ,25]. The changes in lung function reflected corticosteroid responsiveness.…”

Section: Exacerbations Accelerate a Loss Of Lung Functionmentioning

confidence: 99%

Consequences of severe asthma exacerbations

Busse¹

2022

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewAsthma exacerbations are major factors in asthma morbidity and also have long-term consequences.Recent findingsAsthma is characterized by an accelerated and progressive loss of lung function. Recent evidence has pointed to the frequency of exacerbations as being a significant contributor to a loss of lung function in asthma.SummaryA consequence of asthma exacerbations is a greater loss of lung function. Airway inflammation is central to asthma severity and susceptibility for exacerbations. Evidence suggests that the increase in airway inflammation during an asthma exacerbation further compromised lung function. Treatment of severe asthma with Type (T)-2 directed biologics significantly prevents the frequency of exacerbations in severe asthma. Early indications also suggest that prevention of exacerbations by biologics may reduce a loss in lung function from exacerbations.

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Section: Exacerbations Accelerate a Loss Of Lung Functionmentioning

confidence: 99%