Response to osimertinib in a colorectal cancer patient with an EGFR T790M mutation: A case report

Abstract

Minimally invasive surgery is increasingly indicated in the management of malignant disease. Although oesophagectomy is a difficult operation, with a long learning curve, there is actually a shift towards the laparoscopic/thoracoscopic/ robotic approach, due to the advantages of visualization, surgeon comfort (robotic surgery) and the possibility of the whole team to see the operation as well as and the operating surgeon. Although currently there are still many controversial topics, about the surgical treatment of patients with gastro-oesophageal junction (GOJ) adenocarcinoma, such as the type of open or minimally invasive surgical approach, the type of oesophago-gastric resection, the type of lymph node dissection and others, the minimally invasive approach has proven to be a way to reduce postoperative complications of resection, especially by decreasing pulmonary complications. The implementation of new technologies allowed the widening of the range of indications for this type of surgical approach. The short-term and long-term results, as well as the benefits for the patient - reduced surgical trauma, quick and easy recovery - offer this type of surgical treatment the premises for future development. This article reviews the updates and perspectives on the minimally invasive approach for GOJ adenocarcinoma.

JAK1 Is a Novel Target of Tumor- and Invasion-Suppressive microRNA 494-5p in Colorectal Cancer

“…Moreover, Chang and colleagues showed that the depletion of miR-494 by a circular RNA contributes to cisplatin resistance [ 80 ]. Another possible aspect for future therapeutic considerations regarding miR-494 could be its use within combinatorial therapy strategies that can target more than one pathway of cancer cells; here, various kinase inhibitors, such as imatinib, sorafinib, trastuzumab, or osimertinib, already considered for dual therapy in CRC, would be interesting partners [ 81 , 82 , 83 , 84 ]. Towards this end, it has already been shown that miR-494 could play a critical role during imatinib treatment in resistant prostate cancer and CML leukemic stem cells [ 85 , 86 ].…”

Identification of Potential Phytochemical Inhibitors From Conium maculatum Targeting the Epidermal Growth Factor Receptor in Metastatic Colorectal Cancer via Molecular Docking Analysis

“…Targeting EGFR and its inhibition can prevent cancer growth by inducing apoptosis. Buzard et al [ 11 ] investigated the role of osimertinib, an EGFR targeted drug in a patient with metastatic sigmoid colon adenocarcinoma. The treatment for seven months resulted in an improvement in hepatic metastases [ 11 ].…”

“…Buzard et al [ 11 ] investigated the role of osimertinib, an EGFR targeted drug in a patient with metastatic sigmoid colon adenocarcinoma. The treatment for seven months resulted in an improvement in hepatic metastases [ 11 ]. Bioinformatics plays a critical role in drug design, facilitating the discovery and development of new therapeutic agents in a more efficient and targeted manner.…”