Response to Mir et al.

Kulkarni, Anand V.; Kumar, Karan; Premkumar, Madhumita; Rao, Padaki Nagaraja; Reddy, Duvvur Nageshwar

doi:10.14309/ajg.0000000000001760

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Who Can Benefit the Most From Antibiotic Prophylaxis?1

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2022

2023

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Cited by 2 publications

(1 citation statement)

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“…11 SBP was less frequently noted in ACLF patients. 12 Although norfloxacin could not prolong the transplant-free survival in patients with ACLF, norfloxacin led to a reduction in the incidence of hepatic encephalopathy and contained the endotoxin rise. Furthermore, the trial highlighted the beneficial role of prophylactic norfloxacin in patients with alcohol-associated hepatitis receiving steroid therapy.…”

Section: Who Can Benefit the Most From Antibiotic Prophylaxis?mentioning

confidence: 99%

Evidence-Based Commentary: Antibiotics for Prophylaxis of Spontaneous Bacterial Peritonitis

Fatima,

Kulkarni

2022

Journal of Gastrointestinal Infections

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Section: Who Can Benefit the Most From Antibiotic Prophylaxis?mentioning

confidence: 99%

Evidence-Based Commentary: Antibiotics for Prophylaxis of Spontaneous Bacterial Peritonitis

Fatima,

Kulkarni

2022

Journal of Gastrointestinal Infections

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Pathophysiology and management of liver cirrhosis: from portal hypertension to acute-on-chronic liver failure

Jagdish¹,

Roy

Kumar

et al. 2023

Front. Med.

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Cirrhosis transcends various progressive stages from compensation to decompensation driven by the severity of portal hypertension. The downstream effect of increasing portal hypertension severity leads to various pathophysiological pathways, which result in the cardinal complications of cirrhosis, including ascites, variceal hemorrhage, and hepatic encephalopathy. Additionally, the severity of portal hypertension is the central driver for further advanced complications of hyperdynamic circulation, hepatorenal syndrome, and cirrhotic cardiomyopathy. The management of these individual complications has specific nuances which have undergone significant developments. In contrast to the classical natural history of cirrhosis and its complications which follows an insidious trajectory, acute-on-chronic failure (ACLF) leads to a rapidly downhill course with high short-term mortality unless intervened at the early stages. The management of ACLF involves specific interventions, which have quickly evolved in recent years. In this review, we focus on complications of portal hypertension and delve into an approach toward ACLF.

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Response to Mir et al.

Cited by 2 publications

References 10 publications

Evidence-Based Commentary: Antibiotics for Prophylaxis of Spontaneous Bacterial Peritonitis

Evidence-Based Commentary: Antibiotics for Prophylaxis of Spontaneous Bacterial Peritonitis

Pathophysiology and management of liver cirrhosis: from portal hypertension to acute-on-chronic liver failure

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