“…Later, it was also reported that DJ‐1 and its bacterial homologs (Hsp31, YhbO, and YajL) specifically repair the reversible glycated guanosine 5′‐triphosphate (GTP aminocarbinol), but not its delayed end‐products, namely imidazopurinones and carboxyethyl‐deoxyguanosine (Richarme et al, 2017 ). Nevertheless, there is still a debate regarding the deglycase activity of DJ‐1 including potential TRIS buffer artifacts and the D/L‐stereochemistry of the lactate products (Pfaff et al, 2017 ; Richarme, 2017 ). It was recently reported that the apparent deglycase activity of DJ‐1 is the consequence of fast equilibrium between MG and hemithioacetals, likely resulting in the misinterpretation of glyoxalase III as deglycase (Andreeva et al, 2019 ; Gao et al, 2023 ; Mazza et al, 2022 ).…”