Response to letter to the editor: Safety of transcranial direct current stimulation: Evidence based update 2016

Bikson, Marom; Grossman, Pnina; Zannou, Adantchede L.; Kronberg, Greg; Truong, Dennis Q.; Boggio, Paulo S.; Brunoni, André R.; Charvet, Leigh; Fregni, Felipe; Fritsch, Brita; Gillick, Bernadette T.; Hamilton, Roy H.; Hampstead, Benjamin M.; Kirton, Adam; Knotková, Helena; Liebetanz, David; Liu, Anli; Loo, Colleen; Nitsche, Michael A.; Reis, Janine; Richardson, Jessica D.; Rotenberg, Alexander; Turkeltaub, Peter E.; Woods, Adam J.

doi:10.1016/j.brs.2017.06.007

Cited by 7 publications

(3 citation statements)

References 2 publications

(2 reference statements)

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“…The current was applied for 10 min, plus a 15 s ramp-up and ramp-down time, with the peak intensity at 1.5 mA. These parameters are well within the most recent recommendations on tDCS safety, proposed by (Antal et al, 2017 ) (< 4 mA and up to 60 min duration per day) and by Bikson et al, 2016 , 2017 (≤4 mA and ≤40 min in one day). In the sham condition, tDCS was turned on for the 15 s ramp-up and 15 s ramp-down time, with 0 s duration in between.…”

Section: Methodsmentioning

confidence: 61%

Anodal and Cathodal tDCS Over the Right Frontal Eye Fields Impacts Spatial Probability Processing Differently in Pro- and Anti-saccades

Tseng

Wang

et al. 2018

Front. Neurosci.

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Learning regularities that exist in the environment can help the visual system achieve optimal efficiency while reducing computational burden. Using a pro- and anti-saccade task, studies have shown that probabilistic information regarding spatial locations can be a strong modulator of frontal eye fields (FEF) activities and consequently alter saccadic behavior. One recent study has also shown that FEF activities can be modulated by transcranial direct current stimulation, where anodal tDCS facilitated prosaccades but cathodal tDCS prolonged antisaccades. These studies together suggest that location probability and tDCS can both alter FEF activities and oculomotor performance, yet how these two modulators interact with each other remains unclear. In this study, we applied anodal or cathodal tDCS over right FEF, and participants performed an interleaved pro- and anti-saccade task. Location probability was manipulated in prosaccade trials but not antisaccade trials. We observed that anodal tDCS over rFEF facilitated prosaccdes toward low-probability locations but not to high-probability locations; whereas cathodal tDCS facilitated antisaccades away from the high-probability location (i.e., same location as the low-probability locations in prosaccades). These observed effects were specific to rFEF as tDCS over the SEF in a separate control experiment did not yield similar patterns. These effects were also more pronounced in low-performers who had slower saccade reaction time. Together, we conclude that (1) the overlapping spatial endpoint between prosaccades (i.e., toward low-probability location) and antisaccades (i.e., away from high-probability location) possibly suggest an endpoint-selective mechanism within right FEF, (2) anodal tDCS and location probability cannot be combined to produce a bigger facilitative effect, and (3) anodal rFEF tDCS works best on low-performers who had slower saccade reaction time. These observations are consistent with the homeostasis account of tDCS effect and FEF functioning.

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Section: Methodsmentioning

confidence: 61%

Anodal and Cathodal tDCS Over the Right Frontal Eye Fields Impacts Spatial Probability Processing Differently in Pro- and Anti-saccades

Tseng

Wang

et al. 2018

Front. Neurosci.

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“…None were taking medication of any kind, showed previous history of neurological disorders, or psychiatric illness, neither of drug or alcohol abuse. Additionally, all participants met internationally-established safety criteria to receive tDCS (Nitsche et al ., 2003; Bikson et al ., 2017). The local ethics committees of the Open University of Catalonia (UOC) and the institutional review board (IRB 00003099) of the University of Barcelona approved the study, complying with the principles of the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

Modulatory effect of non-invasive prefrontal brain stimulation on risk-taking behaviours in humans: preliminary insight on the influence of personality traits

Torre

Valero‐Cabré

Gallardo-Pujol

et al. 2022

Preprint

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We investigated the modulatory effects of cathodal High-Definition transcranial Direct Current Stimulation (HD-tDCS) on the left dorsolateral prefrontal cortex (DLPFC) and the left ventrolateral prefrontal cortex (VLPFC) on risk-taking. Methods: Thirty-four healthy adults underwent 3 independent cathodal HD-tDCS interventions (DLPFC, VLPFC, sham) delivered in counterbalanced order during the performance of the balloon analogue risk task (autoBART). Participants were clustered post-hoc in 3 separate personality profiles according to the HEXACO-60 and the Dark Triad dirty dozen and we reanalysed the data. Results: Dorsal prefrontal cathodal HD-tDCS significantly modulated autoBART performance rendering participants less prone to risk-taking (i.e., more conservative) under left DLPFC HD-tDCS compared to left VLPFC or sham stimulation. The re-analysis of the same dataset, taking into consideration personality traits, suggested specific effects in impulsive-disinhibited and normative participants for DLPFC and VLPFC stimulation, respectively. Specifically, we saw that participants classified as impulsive-disinhibited were more affected by HD-tDCS left DLPFC stimulation than other profiles. Conclusions: Both, dorsal and ventral prefrontal active HD-tDCS decrease risk-taking behaviour compared to sham stimulation. Importantly, such effects are likely influenced by personality traits (impulsive disinhibited vs normative) exhibited by the participants.

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“…Due to the cerebellar network connections, these techniques can treat a variety of motor symptoms including ataxia and dystonia by addressing the dento-cerebello-thalamic pathway, including the cortex, striatum and subthalamic nucleus 25,65,67,68 . These non-invasive stimulation techniques are relatively easily applicable and well-tolerated by patients 69 . However, these techniques may also induce undesirable side effects, and there are still many caveats including: the optimal intensity, the timing of the stimulation, inter-individual variation between patient-responses, longevity of the effect, unknown effects of combined treatment and incomplete insight in optimal stimulation sites 65,66,[70][71][72] .…”

Section: Treatment Strategies Including Neuro-modulationmentioning

confidence: 99%

Developmental neurobiology of cerebellar and Basal Ganglia connections

Sival

Noort

Tijssen

et al. 2022

European Journal of Paediatric Neurology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Response to letter to the editor: Safety of transcranial direct current stimulation: Evidence based update 2016

Cited by 7 publications

References 2 publications

Anodal and Cathodal tDCS Over the Right Frontal Eye Fields Impacts Spatial Probability Processing Differently in Pro- and Anti-saccades

Anodal and Cathodal tDCS Over the Right Frontal Eye Fields Impacts Spatial Probability Processing Differently in Pro- and Anti-saccades

Modulatory effect of non-invasive prefrontal brain stimulation on risk-taking behaviours in humans: preliminary insight on the influence of personality traits

Developmental neurobiology of cerebellar and Basal Ganglia connections

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