Response to “Letter to the editor re: Cheng YH, Chou WC, Yang YF, et al. Environ Sci Pollut Res (2018). https://doi.org/10.107/s11356-017-0875-4”

Cheng, Yi-Hsien; Chou, Wei-Chun; Yang, Ying‐Fei; Huang, Chi‐Wei; How, Chun Ming; Chen, Szu-Chieh; Chen, Wei-Yu; Hsieh, Nan‐Hung; Lin, Y.; You, Shu-Han; Liao, Chung‐Min

doi:10.1007/s11356-018-3178-5

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…EGCG down-regulates inflammatory cytokine in HT29 and T84 colon cancer cells [52]. Moreover, it was shown that antimetastatic effects of EGCG on uveal melanoma cells via the downregulation of MMP2 [53]. Furthermore, EGCG treatment in periodontitis inhibits CCL11 production [54].…”

Section: Figure 7bmentioning

confidence: 99%

In Silico and In Vitro Studies Evidenced Anticancer Natural Compounds, a Targeting Chemokine Receptor

Singh¹,

Bast²

2016

Ann Clin Lab Res

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Chemokines are a family of small chemotactic cytokines, which play a significant role in lymphocyte homing to secondary lymphoid organs in addition to tumor growth and metastasis. Thus, inhibition of chemokine receptor caught attention for anticancer treatment strategy. We studied molecular docking of chemokines receptor CXCR2, CXCR4, and CCR5 against natural and marine compounds. All selected natural and marine compounds were docked with the X-ray crystal structure of CXCR2, CXCR4, and CCR5 retrieved from the PDB by using Maestro 9.6. Molecular docking was executed by the XP (extra precision) mode of GLIDE. On the basis of Gscore and protein-ligand interactions, top-ranking compounds were outlined. The docking study carried out to summarize the various Gscore, hydrophobic, electrostatic bond, hydrogen bond, π-cation and π-π interactions and oversee the protein-ligand interactions. Moreover, effect of Epigallocatechin-3-gallate (EGCG) on biological activity such as mRNA expression (CXCR2, CCR5, and Bid), cell proliferation, ROS, and cell-migration was reported after the 48 hrs treatments in MCF-7 cells. The RT-PCR densitometric bands analysis showed that compound EGCG reduced the mRNA expression of CXCR2, CCR5 and increased the Bid at 40 µM and 80 μM concentration. Moreover, EGCG significantly reduced cell proliferation, ROS generation and cell-migration after 48 hours treatments.

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Section: Figure 7bmentioning

confidence: 99%

In Silico and In Vitro Studies Evidenced Anticancer Natural Compounds, a Targeting Chemokine Receptor

Singh¹,

Bast²

2016

Ann Clin Lab Res

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“…However, the value of 18 F-FDG PET/CT in the diagnosis of GEP-NENs is still controversial since GEP-NENs generally exhibit indolent biological behavior with low glycolytic activity. Several studies have reported that 18 F-FDG PET/CT has an acceptable diagnostic value for aggressive GEP-NENs with a Ki-67 index greater than or equal to 10% and low expression of SSTRs [91,92]. Recently, two imaging classifications of NENs were developed based on 68 Ga-DOTATATE and 18 F-FDG PET/CTs [93,94].…”

Section: Imagingmentioning

confidence: 99%

Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

Zhang,

Fan,

Jing

et al. 2024

Military Med Res

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Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common subtype of NENs. Historically, GEP-NENs have been regarded as infrequent and slow-growing malignancies; however, recent data have demonstrated that the worldwide prevalence and incidence of GEP-NENs have increased exponentially over the last three decades. In addition, an increasing number of studies have proven that GEP-NENs result in a limited life expectancy. These findings suggested that the natural biology of GEP-NENs is more aggressive than commonly assumed. Therefore, there is an urgent need for advanced researches focusing on the diagnosis and management of patients with GEP-NENs. In this review, we have summarized the limitations and recent advancements in our comprehension of the epidemiology, clinical presentations, pathology, molecular biology, diagnosis, and treatment of GEP-NETs to identify factors contributing to delays in diagnosis and timely treatment of these patients.

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“…The addition of gelatin to a C/GP hydrogel can improve the gel strength and shorten the gelation time, thus potentially preventing drug loss and providing better sustained release properties [26,37]. SEM images show a highly porous structure of the FA-loaded hydrogel that may allow the drug to freely diffuse and release ( Fig.…”

Section: In Vivo Biocompatibility Of Fa-loaded Hydrogelmentioning

confidence: 99%

Recovery of oxidative stress-induced damage in Cisd2-deficient cardiomyocytes by sustained release of ferulic acid from injectable hydrogel

et al. 2016

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Response to “Letter to the editor re: Cheng YH, Chou WC, Yang YF, et al. Environ Sci Pollut Res (2018). https://doi.org/10.107/s11356-017-0875-4”

Cited by 6 publications

References 16 publications

In Silico and In Vitro Studies Evidenced Anticancer Natural Compounds, a Targeting Chemokine Receptor

In Silico and In Vitro Studies Evidenced Anticancer Natural Compounds, a Targeting Chemokine Receptor

Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

Recovery of oxidative stress-induced damage in Cisd2-deficient cardiomyocytes by sustained release of ferulic acid from injectable hydrogel

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