Response to: Kimura’s disease: effects of age on clinical presentation

Kakehi, Eiichi; Kotani, Kazuhiko; Otsuka, Yoshihisa; Fukuyasu, Yusuke; Hashimoto, Yukiko; Sakurai, Sho; Hirotani, Akane; Simizu, K; Fujita, Ryosuke; Shoji, K; Adachi, Seiji; Matsumura, Masami

doi:10.1093/qjmed/hcaa035

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2024

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“…1 KD is prevalent in Asians, with a male-to-female ratio of 4:1. 3 Its slow progression is accompanied by elevated peripheral blood eosinophil counts and serum immunoglobulin (Ig) E levels. Simple KD without other organ damage often presents as painless subcutaneous masses on the head and neck but may also appear in the axillae, inguinal region, abdomen, chest wall, and peripheral limbs, but it is very rare.…”

Section: Introductionmentioning

confidence: 99%

A Case of Insidious Onset of Kimura Disease-associated Immunoglobulin A Nephropathy without Eosinophil Infiltration in the Renal Tissue

Liu,

Gou,

Liu

et al. 2024

IJAAI

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Kimura disease (KD), also known as eosinophilic lymphogranuloma, is a rare chronic inflammatory or allergic disease. It can present with immune-related diseases such as nephrotic syndrome, asthma, and ankylosing spondylitis. In this study, we report a case of KD combined with immunoglobulin A nephropathy that first presented as a mass in the inguinal region, followed by recurrent renal involvement. Previous reports suggested that renal involvement caused by KD was due to direct infiltration of eosinophils; however, in this case, no eosinophil infiltration was found in the renal tissue after renal biopsy. This observation reminds us to approach the case from an immune-related molecular perspective to investigate the exact cause of renal damage due to KD.

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Section: Introductionmentioning

confidence: 99%