Response to ionising radiation in Duchenne muscular dystrophy

Howlett, Rolfe; Kakulas, B. A.; Ra, Fox

doi:10.1016/0022-510x(83)90011-4

Cited by 3 publications

(2 citation statements)

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“…One difference between the two investigations was that Robbins et al" measured cell survival at a single radiation dose, whereas Howlett et al'54 used increasing dosages and took the slope of the resulting survival plot as the parameter for assessing sensitivity. It is noteworthy that at the dosage used by Robbins et al" (100 rad), the differences detected by Howlett et al 54 were at a minimum.…”

Section: Dna Damage and Dmd Cellsmentioning

confidence: 73%

“…There are neuropathic disorders in which increased sensitivity to DNA-damaging agents has been demonstrated in cells in ~u l t u r e .~~~' ,~' The rationale for examining the response of DMD cells to such agents is not clear; as Howlett et al 54 pointed out, DMD is apparently not a neuropathic disorder, nor is there evidence of an increased incidence of tumors. This has not deterred studies of this type being made in DMD, and the effects of both radiation and chemical mutagens on DMD cells have been described.…”

Section: Dna Damage and Dmd Cellsmentioning

confidence: 99%

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Tissue culture studies of muscle disorders: Part 1. Techniques, cell growth, morphology, cell surface

Witkowski¹

1986

Muscle and Nerve

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Tissue culture has been used extensively in studies of human inherited disorders, and its application in the field of the neuromuscular disorders has increased rapidly in recent years. This review, covering the period 1977 to 1984, deals with tissue culture studies of both human and animal muscle disorders, although Duchenne muscular dystrophy (DMD) figures prominently because of the overwhelming interest in that disorder. The review is in two parts. In the first part, I discuss technical innovations in the field, the morphology and growth of cells, and a variety of studies related to the cell surface. Important findings in relation to DMD include reports of abnormal growth rates and reduced lifespan of DMD cells, hypersensitivity to DNA-damaging agents, abnormal cell-to-cell and cell-to-substratum adhesion, and a more "fluid" cell membrane. However, these findings are controversial or have so far been reported only by single laboratories.

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Section: Dna Damage and Dmd Cellsmentioning

confidence: 73%

Section: Dna Damage and Dmd Cellsmentioning

confidence: 99%

Tissue culture studies of muscle disorders: Part 1. Techniques, cell growth, morphology, cell surface

Witkowski¹

1986

Muscle and Nerve

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Response to DNA-damaging agents in cultured cells from patients with X-linked duchenne muscular dystrophy phenotype: male DMD, female DMD, possible carriers

et al. 1987

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Using blood cultures the response to gamma (γ) radiation was examined in a male DMD and his mother, in a female DMD and her mother and in a normal control. In a series of experiments chromosome aberrations were determined after 3 separate γ-irradiation dose levels: 0, 150, 300 rads. The DMD patients showed a response to ionising radiations different from control, in fact the percentage of aberrations was lower than the control. In this preliminary study a slight difference between normal and possible carriers was also found.

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A sensitive assay for detecting hypersensitivity to ionizing radiation in lymphoblastoid lines from patients with duchenne muscular dystrophy and primary neuronal degenerations

Tarone

Otsuka

Robbins

1984

Journal of the Neurological Sciences

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Response to ionising radiation in Duchenne muscular dystrophy

Cited by 3 publications

References 13 publications

Tissue culture studies of muscle disorders: Part 1. Techniques, cell growth, morphology, cell surface

Tissue culture studies of muscle disorders: Part 1. Techniques, cell growth, morphology, cell surface

Response to DNA-damaging agents in cultured cells from patients with X-linked duchenne muscular dystrophy phenotype: male DMD, female DMD, possible carriers

A sensitive assay for detecting hypersensitivity to ionizing radiation in lymphoblastoid lines from patients with duchenne muscular dystrophy and primary neuronal degenerations

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