Response to: High-grade squamous intraepithelial lesion (HSIL) of the cervix with bizarre cytological appearances (‘pleomorphic HSIL’)

Ondič, Ondřej; Alaghehbandan, Reza

doi:10.1016/j.pathol.2017.09.023

Cited by 1 publication

(1 citation statement)

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“…Ondic and Alaghehbandan described the histological features of PHSIL as being similar to those of bizarre cell dysplasia (BCD) [ 24 , 25 ]. Although there is a morphological overlap between PHSIL and BCD, significant differences exist, particularly in regards to the distribution of the bizarre cells.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Characteristics of Pleomorphic High-Grade Squamous Intraepithelial Lesion of the Uterine Cervix: A Single-Institutional Series of 31 Cases

Kim

Choi

et al. 2020

Diagnostics

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We investigated the clinicopathological characteristics of 31 cases of pleomorphic high-grade squamous intraepithelial lesions (PHSIL) of the uterine cervix. We reviewed electronic medical records and all available slides to collect clinical and pathological information. PHSILs were histologically characterized by significant nuclear enlargement, marked pleomorphism, hyperchromasia, increased mitotic activity, and frequent atypical mitoses. In the majority of cases (24/31; 77.4%), this striking nuclear atypia involved both the surface epithelium and the endocervical glands. In the remaining seven cases, pleomorphic cells were observed in the surface epithelium only. PHSILs involving both the surface epithelium and glands showed higher mitotic counts and Ki-67 labelling indices than the surface-only PHSILs. Invasive squamous cell carcinoma was present in only one case (3.2%), and none developed recurrent disease. Our observations of striking nuclear atypia in cases of HSIL did not indicate increased aggressiveness. Further investigations are required for confirmation of our data in larger cohorts.

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Section: Discussionmentioning

confidence: 99%