Response to hepatitis B immunization by infants exposed to HIV

Rutstein, Richard M.; Rudy, Bret J.; Codispoti, Cindy; Watson, Barbara

doi:10.1097/00002030-199409000-00010

Cited by 39 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite booster doses, one HIV-positive man did not show any antibody response. Previous studies have demonstrated poor responses in immunocompromised patients 13,14 . The response is believed to be independent of CD4 counts but probably affected by lifestyle, e.g.…”

Section: Discussionmentioning

confidence: 95%

Audit of hepatitis B immunization at the genitourinary medicine department in Middlesbrough, UK

Opaneye

Bashford

2002

Int J STD AIDS

View full text Add to dashboard Cite

The outcomes of hepatitis B immunization programme at the genitourinary medicine (GUM) department in Middlesbrough during a period of five years were examined. The majority of those immunized were male homosexuals who had earlier requested an HIV test. All participants had preimmunization hepatitis B serology, and were negative. The default rate was high at 20/42 (47.6%). However, among those who completed all the processes, seroconversion rate was high at 21/22 (95.5%). The only non-responder was a man who was HIV-positive. The type of vaccine and immunization regimen are discussed.

show abstract

Section: Discussionmentioning

confidence: 95%

Audit of hepatitis B immunization at the genitourinary medicine department in Middlesbrough, UK

Opaneye

Bashford

2002

Int J STD AIDS

View full text Add to dashboard Cite

show abstract

“…For example, this could be caused by a high prevalence of chronic and/or immunosuppressive infections (e.g. intestinal helminths and HIV), they may be very young or affected by old age, have poor nutrition, suffer from obesity, have pre-existing immunity to vaccine vectors (such as recombinant adenovirus) or are naturally exposed to antigenically similar organisms to the target pathogen (Elias et al, 2001;Karlsson et al, 2010;Kaufman et al, 2011;Moretto et al, 2008;Rutstein et al, 1994;Sasaki et al, 2011;Sekaly, 2008). Vaccine formulations must be found that can succeed, despite these difficult circumstances.…”

Section: The Immunological Challengesmentioning

confidence: 99%

The current challenges for vaccine development

Oyston

Robinson

2012

Journal of Medical Microbiology

104

View full text Add to dashboard Cite

Vaccine development has played a hugely important role in combating infectious disease. Despite this success, there is still a great need for new vaccines and these are emerging far more slowly than we would wish. Despite the massive expansion in understanding of immune responses to infection, research is often hindered by a lack of understanding of the immune responses required specifically for protection, or by a lack of approved adjuvants and delivery systems to induce the required responses. In addition, the financial commitment required to license new vaccines is significant, and the more lucrative markets are often not those with the greatest need. In this review, we discuss many of the hurdles that new vaccines must overcome in order to reduce morbidity and mortality, and some of the initiatives that are being attempted to supply new vaccines to those that need them most.

show abstract

“…Studies in infants born to HIV-infected mothers showed that children who 3 became infected with HIV responded poorly to HBV vaccine and the duration of protection was less, as compared to children who were not infected [7,68,76,83,85].…”

Section: Hepatitis B Virus (Hbv) Vaccinementioning

confidence: 99%