Response to: ‘Digital health: a new dimension in rheumatology patient care’ by Kataria and Ravindran

Burmester, Gerd R

doi:10.1136/annrheumdis-2018-214154

Cited by 6 publications

(1 citation statement)

References 2 publications

(2 reference statements)

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“…A first publication on a hero in the ‘Heroes and Pillars of Rheumatology’ part has also appeared,5 a section intended to tell the younger rheumatologists about people (or publications) that paved the roads to modern rheumatology—more will follow. Finally, ARD also made an initial blink into the ‘unthinkable’ future,6 which already elicited an interesting online discussion 7 8…”

mentioning

confidence: 99%

Greetings from the editor 2019

Smolen

2018

Ann Rheum Dis

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mentioning

confidence: 99%

Greetings from the editor 2019

Smolen

2018

Ann Rheum Dis

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Upadacitinib in Rheumatoid Arthritis: A Benefit–Risk Assessment Across a Phase III Program

Conaghan

Mysler²,

Tanaka

et al. 2021

Drug Saf

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Treating to a target of clinical remission or low disease activity is an important principle for managing rheumatoid arthritis (RA). Despite the availability of biologic disease-modifying antirheumatic drugs (bDMARDs), a substantial proportion of patients with RA do not achieve these treatment targets. Upadacitinib is a once-daily, oral Janus kinase (JAK) inhibitor with increased selectivity for JAK1 over JAK2, JAK3, and tyrosine kinase 2. The SELECT phase III upadacitinib clinical program comprised five pivotal trials of approximately 4400 patients with RA, including inadequate responders (IR) to conventional synthetic (cs)DMARDs or bDMARDs. This review aims to provide insights into the benefit–risk profile of upadacitinib in patients with RA. Upadacitinib 15 mg once daily, in combination with csDMARDs or as monotherapy, achieved all primary and ranked secondary endpoints in the five pivotal trials across csDMARD-naïve, csDMARD-IR, and bDMARD-IR populations. Upadacitinib 15 mg also demonstrated significantly higher rates of remission and low disease activity in all five pivotal trials, compared with placebo, methotrexate, or adalimumab. Labeled warnings of JAK inhibitors include serious infections, herpes zoster, malignancies, major cardiovascular events, and venous thromboembolic events. Short- and long-term integrated analyses showed that upadacitinib 15 mg was associated with increased risk of herpes zoster and creatine phosphokinase elevations compared with methotrexate and adalimumab but otherwise had comparable safety with these active comparators. This review suggests that upadacitinib 15 mg had a favorable benefit–risk profile. The safety of upadacitinib will continue to be monitored in long-term extensions and post-marketing studies. Supplementary Information The online version contains supplementary material available at 10.1007/s40264-020-01036-w.

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Precision medicine in autoimmune disease

Deane

2021

Precision Medicine and Artificial Intelligence

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Response to: ‘Digital health: a new dimension in rheumatology patient care’ by Kataria and Ravindran

Cited by 6 publications

References 2 publications

Greetings from the editor 2019

Greetings from the editor 2019

Upadacitinib in Rheumatoid Arthritis: A Benefit–Risk Assessment Across a Phase III Program

Precision medicine in autoimmune disease

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