Response to correction of refractive errors and hypoaccommodation in children with congenital Zika syndrome

Ventura, Liana O.; Lawrence, Linda; Ventura, Camila V.; Dutton, Gordon N.; Marinho, Polyana; Ferro, Priscila F.; Gois, Adriana L.; Dias, Natália; Ventura, Larissa; Moore, Cynthia A.; Hyvärinen, Lea

doi:10.1016/j.jaapos.2017.07.206

Cited by 17 publications

(9 citation statements)

References 23 publications

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“…Because the full spectrum of adverse outcomes related to congenital Zika virus infection is not yet known, careful monitoring and evaluation of children born to mothers with laboratory evidence of confirmed or possible Zika virus infection during pregnancy is essential for ensuring early detection of possible disabilities and early referral to intervention services that might improve outcomes. For example, with early identification of vision problems, a prescription for corrective eyeglasses might be beneficial to a child’s development ( 12 ). Among children without microcephaly detected at birth, brain or eye anomalies might have gone undetected without neuroimaging or ophthalmologic evaluation.…”

Section: Conclusion and Commentsmentioning

confidence: 99%

“…As infants with congenital Zika virus infection get older, problems such as epilepsy, vision loss, and developmental delays have been increasingly recognized ( 8 ). Early identification of and intervention for adverse neurodevelopmental outcomes have been determined to improve cognitive, social, and behavioral functioning and to be cost effective to society in general ( 9 – 12 ). …”

Section: Introductionmentioning

confidence: 99%

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Vital Signs:Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018

Rice¹,

Galang²,

Roth³

et al. 2018

MMWR Morb. Mortal. Wkly. Rep.

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IntroductionZika virus infection during pregnancy causes serious birth defects and might be associated with neurodevelopmental abnormalities in children. Early identification of and intervention for neurodevelopmental problems can improve cognitive, social, and behavioral functioning.MethodsPregnancies with laboratory evidence of confirmed or possible Zika virus infection and infants resulting from these pregnancies are included in the U.S. Zika Pregnancy and Infant Registry (USZPIR) and followed through active surveillance methods. This report includes data on children aged ≥1 year born in U.S. territories and freely associated states. Receipt of reported follow-up care was assessed, and data were reviewed to identify Zika-associated birth defects and neurodevelopmental abnormalities possibly associated with congenital Zika virus infection.ResultsAmong 1,450 children of mothers with laboratory evidence of confirmed or possible Zika virus infection during pregnancy and with reported follow-up care, 76% had developmental screening or evaluation, 60% had postnatal neuroimaging, 48% had automated auditory brainstem response-based hearing screen or evaluation, and 36% had an ophthalmologic evaluation. Among evaluated children, 6% had at least one Zika-associated birth defect identified, 9% had at least one neurodevelopmental abnormality possibly associated with congenital Zika virus infection identified, and 1% had both.ConclusionOne in seven evaluated children had a Zika-associated birth defect, a neurodevelopmental abnormality possibly associated with congenital Zika virus infection, or both reported to the USZPIR. Given that most children did not have evidence of all recommended evaluations, additional anomalies might not have been identified. Careful monitoring and evaluation of children born to mothers with evidence of Zika virus infection during pregnancy is essential for ensuring early detection of possible disabilities and early referral to intervention services.

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Section: Conclusion and Commentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vital Signs:Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018

Rice¹,

Galang²,

Roth³

et al. 2018

MMWR Morb. Mortal. Wkly. Rep.

Self Cite

190

237

View full text Add to dashboard Cite

show abstract

“…Regarding CZS, the French Ministry of Health and CDC recommend mandatory comprehensive ophthalmic screening in all children born to a mother infected during pregnancy, prior to 1 month of age, with a further fundus exam repeated at 1 year [147,148]. Early detection and expedient refractive correction can lead to immediate improvements in visual function in these children [149].…”

Section: Zika* (Flaviviridae)mentioning

confidence: 99%

Ocular manifestations of emerging viral diseases

Venkatesh

Patel

Goyal

et al. 2021

Eye

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Emerging infectious diseases (EIDs) are an increasing threat to public health on a global scale. In recent times, the most prominent outbreaks have constituted RNA viruses, spreading via droplets (COVID-19 and Influenza A H1N1), directly between humans (Ebola and Marburg), via arthropod vectors (Dengue, Zika, West Nile, Chikungunya, Crimean Congo) and zoonotically (Lassa fever, Nipah, Rift Valley fever, Hantaviruses). However, specific approved antiviral therapies and vaccine availability are scarce, and public health measures remain critical. Patients can present with a spectrum of ocular manifestations. Emerging infectious diseases should therefore be considered in the differential diagnosis of ocular inflammatory conditions in patients inhabiting or returning from endemic territories, and more general vigilance is advisable in the context of a global pandemic. Eye specialists are in a position to facilitate swift diagnosis, improve clinical outcomes, and contribute to wider public health efforts during outbreaks. This article reviews those emerging viral diseases associated with reports of ocular manifestations and summarizes details pertinent to practicing eye specialists.

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“…Ocular compromise in children require a multidisciplinary approach and a focused treatment according to the present ocular conditions [53]. Cases with refractive errors, anisometropias, hypoaccomodation, amblyopia, and strabismus requires visual development therapies (eyeglasses, patching, ortoptics, and strabismus surgery) that are key in visual rehabilitation [12,98].…”

Section: Ocular Treatmentmentioning

confidence: 99%

The Eye and the Zika Virus

Martínez-Pulgarín¹,

Córdoba-Ortega²,

Padilla-Pantoja³

2021

Current Concepts in Zika Research

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Ocular involvement in Zika virus (ZIKV) infection can be present both in adults and infants as acquired and congenital diseases respectively. Through experimental studies, there has been clarified important mechanisms of ocular pathogenesis that allow the establishment of potential objectives for antiviral drugs development. The spread of the virus at the ocular level could be hematogenous or axonal, however the hematogenous route through the choroid is suggested as the most important initial mechanism for infection. Ocular manifestations vary according to the age of presentation, being mild and self-limited in adults and potentially devastating in children, related to congenital Zika syndrome (CZS). Ocular diagnosis is made based in clinical features and contact/travel history to countries of epidemiological importance; fundoscopy, optical coherence tomography, fluoresceinic/green indocianine angiography, cultures, serological and molecular tests are useful diagnostic tools. Ocular management is focused according to the clinical context of each patient. Prevention is carried out in a comprehensive manner and further research is directed to vaccine development and specific antiviral treatment. Proper attention requires a multidisciplinary team in order to reach complete visual evaluation and early rehabilitation.

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Response to correction of refractive errors and hypoaccommodation in children with congenital Zika syndrome

Cited by 17 publications

References 23 publications

Vital Signs:Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018

Vital Signs:Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018

Ocular manifestations of emerging viral diseases

The Eye and the Zika Virus

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