Response to comments to the editor on “Disease severity and efficacy of homologous vaccination among patients infected with SARS‐CoV‐2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkers”

Ali, Ayad M.; Tofiq, Ahmed M.; Rostam, Hassan M.; Ali, Kameran Mohammed; Tawfeeq, Hassan Mohammad

doi:10.1002/jmv.28820

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…This could be because the increase in CRP levels is lower in younger people infected with COVID-19 [43]. ESR is another clinically widely used in ammatory marker that is elevated during COVID-19 infection [42,44,45]. The majority of CCOGA ingredients, including Matricaria chamomilla, Cinnamomum verum, and Zingiber o cinale, have anti-in ammatory properties [29,46].…”

Section: Discussionmentioning

confidence: 99%

A polyherbal remedy of Chamomile, Cinnamon, Oregano, Ginger, and Anise (CCOGA) combined with physician-prescribed medication is a promising COVID-19 therapy.

Ali,

Rashid,

M.Ali

et al. 2023

Preprint

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Introduction: The world has been on high pandemic alert subsequent to the severe acute respiratory syndrome coronavirus (SARS-CoV-2) outbreak. In the first two years of the pandemic, there was no definitive treatment for coronavirus disease 2019 (COVID-19). Traditionally, herbal remedies were seen as a means of treating respiratory infections. The objective of this study is to evaluate the effect of a polyherbal remedy made of chamomile, cinnamon, oregano, ginger, and anise (CCOGA) on curing the COVID-19 infection. Methods: This study used randomized, parallel control and treatment arms of COVID-19 outpatients. The control group receives only physician prescribes medications, whereas the treatment group receives physician prescribes medication plus CCOGA polyherbal remedy once a day for one week. The patients were evaluated at baseline and on day 7 for several biomarker tests, including: PCR cycle threshold values (PCR-Ct), total WBC count, lymphocyte count, C-reaction protein (CRP), erythrocyte sedimentation rate (ESR), and peripheral oxygen saturation (SpO2). Result: CCOGA significantly reduces the viral load in the patients of the treatment arm. In addition, CCOGA significantly improves leukocyte, lymphocyte, and CRP levels in the middle-aged and elderly groups of the treatment arm. Older individuals who did not undergo CCOGA treatment had a significantly higher ESR and lower SpO2 than the corresponding age in treatment group. Conclusion: The CCOGA polyherbal remedy reduces viral load and improves the prognostic biomarker of inflammation in COVID-19 outpatients, and it may be a promising remedy for elder patients.

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Section: Discussionmentioning

confidence: 99%

A polyherbal remedy of Chamomile, Cinnamon, Oregano, Ginger, and Anise (CCOGA) combined with physician-prescribed medication is a promising COVID-19 therapy.

Ali,

Rashid,

M.Ali

et al. 2023

Preprint

Self Cite

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The influence of SARS‐CoV‐2 on male reproduction and men's health

Ali,

Abdlwahid,

Ali

et al. 2023

Eur J Clin Investigation

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BackgroundSARS‐CoV‐2, the virus responsible for COVID‐19, primarily affects the respiratory system by targeting the Angiotensin‐converting enzyme 2 (ACE2) receptor and TMPRSS2. However, these receptors are also present in other organs, including the testes, where a higher concentration of ACE2 receptors has been observed. This raises concerns about the potential impact of the virus on male fertility.AimsIn this study, we aimed to assess the effects of SARS‐CoV‐2 on semen parameters by comparing samples during and after infection in the same patients.Materials & MethodThe study enrolled 51 individuals who had contracted COVID‐19 and analysed various parameters related to sperm quality and quantity, including C‐reactive protein, testosterone levels, total sperm concentration, motility and morphology. A comparison was made between these parameters during the initial infection with SARS‐CoV‐2 and after a 2‐ and 5‐month recovery period.ResultsThe results indicated that all of the mentioned parameters were significantly affected during COVID‐19 infection (PCR‐ct, CRP, WBCs LH, FSH and testosterone levels, p‐value = .0001). Furthermore, the study assessed TC, TM and sperm morphology in patients infected with SARS‐CoV‐2 and found that these parameters were also significantly influenced during the infection, (p‐value = .0001; Morphology, p‐value = .0004). We observed significant alterations in sperm count and morphology during infection, suggesting a potential negative impact on sperm quality. Additionally, lower hormone levels were observed during COVID‐19 infection, possibly due to increased inflammatory cytokines. However, both hormones and inflammation markers returned to normal following recovery. Our findings indicate a statistically significant change in total sperm count, motility and morphology post‐infection, which aligns with previous studies. Discussion, COVID‐19 have a transient impact on sperm parameters and fertility, emphasizing the importance of further investigation into the long‐term implications.

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The Study on Side Effects Caused by Pfizer/BioNTech COVID-19 Vaccine: Focus on IgG Antibodies, and Serological Biomarkers

Ali,

Rashid,

M.Ali

et al. 2024

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Background A SARS-CoV-2 pandemic that spread swiftly is now a major global public health issue. Vaccines are currently being distributed in an effort to limit the viral transmission and mortality. Objectives monitoring of both safety and efficacy in determining the overall effectiveness of the vaccine and identifying any potential safety concerns. Methods A retrospective, cross-sectional study employing a validated 13-item structured questionnaire divided into two sections between March 2022 and September 2022. Different post-vaccination side effects SE according to symptoms severity in terms of age and sex for participants were reported. Additionally, some pertinent serological assays for participant’s post-vaccinations were investigated. Results A total of 502 participants (male: 262: female: 240) with comorbidity (healthy: 258: morbid: 244) who received two Pfizer/BioNTech mRNA vaccine doses were included. Importantly, second dose D2 SE experienced a significant more SE than single dose D1 vaccination (P < 0.0001). Hence, in D1 vaccination the injection site pain ISP (45%), followed by equal proportion of headache and fever (40%) were the most common vaccine’s SE, while in D2 vaccination, the ISP (66%), nausea (57%) reported respectively. 97% (P < 0.0001) of participants reported a positive IgG antibody within D2 vaccination. Similarly, serum CR-Protein level was elevated significantly (P < 0.0001) corresponding to the severity of SE between D1 and D2. Significant differences are reported between M, F and ages between both D1 and D2 vaccination(P < 0.0001). Conclusions In light of the extensive data from this study, it is evident that mRNA vaccines, particularly the Pfizer/BioNTech vaccine, have proven highly safe and effective in mitigating the impact of the SARS-CoV-2 pandemic.

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Response to comments to the editor on “Disease severity and efficacy of homologous vaccination among patients infected with SARS‐CoV‐2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkers”

Cited by 4 publications

References 6 publications

A polyherbal remedy of Chamomile, Cinnamon, Oregano, Ginger, and Anise (CCOGA) combined with physician-prescribed medication is a promising COVID-19 therapy.

A polyherbal remedy of Chamomile, Cinnamon, Oregano, Ginger, and Anise (CCOGA) combined with physician-prescribed medication is a promising COVID-19 therapy.

The influence of SARS‐CoV‐2 on male reproduction and men's health

The Study on Side Effects Caused by Pfizer/BioNTech COVID-19 Vaccine: Focus on IgG Antibodies, and Serological Biomarkers

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