Abstract:We appreciate the commentary by Prof. Mancia on our manuscript [1].He argues that randomized trials are not feasible to certain areas, particularly epidemiology, diagnosis, and patients' follow-up [2]. We agree that in the current climate, randomized trials of such topics are not feasible.However, all observational studies are subject to confounding; there are numerous examples in the literature of observational studies or expert opinion being contradicted by the results of well-conducted randomized clinical t… Show more
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