“…Recently, there has been significant progress in establishing the physical theory and foundation as well as the quantification of the Waddington landscape (Wang et al, 2008;Wang J. et al, 2011;Wang, 2015;Zhou and Li, 2016). A detailed comparison and critical review of various approaches was presented in (Zhou and Li, 2016). To find the core mechanisms of the mammalian cellular aging process, we built a gene regulatory network based on the existing experimental literature (Haruta et al, 2000;Stambolic et al, 2001;Inoki et al, 2002Inoki et al, , 2003Ogawara et al, 2002;Kong, 2004;Lahav et al, 2004;Nemoto, 2004;You et al, 2006;Greer et al, 2007b;Okoshi et al, 2007;Budanov and Karin, 2008;Gwinn et al, 2008;Lan et al, 2008;Salih and Brunet, 2008;Cantó et al, 2009;Chen et al, 2010;Georgescu, 2010;Ghosh et al, 2010;Sengupta et al, 2010;Yi and Luo, 2010;Budanov, 2011;Dunlop et al, 2011;Gao et al, 2011;Kim et al, 2011;Löffler et al, 2011;Renault et al, 2011;Wang F. et al, 2011;Parmigiani et al, 2014).…”