Response to cancer therapy in a patient with a paraneoplastic choreiform disorder

Croteau, David; Owainati, A.; Dalmau, Josep; Rogers, Lisa

doi:10.1212/wnl.57.4.719

Cited by 38 publications

(23 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nonetheless, in some cases, hyperintensity in T2-FLAIR sequences of the basal ganglia can be transitory and disappear after a few months, or can be absent at neurological symptoms onset and become manifest shortly afterwards. [7,9,14]. It is not currently possible to define whether this picture is strictly related to this PNS.…”

Section: Discussionmentioning

confidence: 97%

“…We also analyzed 29 patients described in previous reports [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Articles on movement disorders associated with cancer were identified by searching PubMed using the terms chorea, dystonia, dyskinesia, ballism, athetosis, choreoathetosis, paraneoplastic, and cancer/tumor.…”

Section: Methodsmentioning

confidence: 99%

“…Nevertheless, they can rarely be observed in cancer patients and a paraneoplastic origin has been suggested in these cases. To date, less than 30 patients with chorea/dystonia associated with cancer have been reported in the literature, hence the clinical specificities of this peculiar paraneoplastic syndrome are not clearly defined [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. This study was aimed at better characterizing paraneoplastic chorea and dystonia by analyzing the cases collected by the members of the paraneoplastic neurological syndrome (PNS) EuroNetwork and reviewing additional cases from the literature.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chorea and related movement disorders of paraneoplastic origin: the PNS EuroNetwork experience

et al. 2011

View full text Add to dashboard Cite

Chorea and other movement disorders are rarely described as paraneoplastic. The aim of this study was to describe 13 patients with paraneoplastic chorea and dystonia collected by the members of the paraneoplastic neurological syndrome (PNS) EuroNetwork and to review 29 cases from the literature. We analyzed neurological symptoms, severity of the neurological syndrome, delay in neurological diagnosis, associated cancer, oncological and neurological treatments received, and outcome. Eleven (1.2%) out of 913 patients with PNS were identified in the EuroNetwork register. Two more patients not included in the register were added. The overall population consisted of 13 patients with a median age of 75 years (range 49-82 years). In most patients, the movement disorder was classical choreoathetosis with symmetric involvement of the trunk, neck, and limbs. A minority of patients presented unilateral chorea, dystonia, and orobuccal dyskinesia. Associated symptoms, as polyneuropathy, encephalitis, psychiatric disturbances, or visual defects, were often present. The movement disorder usually had a subacute course. The most frequently associated cancer was small cell lung cancer (SCLC). Lymphoma, bowel, or kidney cancers were also reported. CV2/CRMP5 was the most frequently associated antibody, followed by Hu. Hyperintense lesions of the basal ganglia on T2-weighted images were seldom observed. Response to cancer therapy was observed in a minority of patients, but survival was short (17 months). As in other neurological diseases, movement disorders should also be suspected as paraneoplastic when they develop subacutely in older patients (usually over 50) and often in the presence of other ancillary neurological symptoms.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chorea and related movement disorders of paraneoplastic origin: the PNS EuroNetwork experience

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Compared to that with antibodies against surface antigens, AE diseases with antibodies directed toward intracellular antigens are often considered to be poorly responsive to immunologic therapies (132, 160, 161). This is probably related to the pathologic features that they are often subacute and associated with neuronal loss mediated by T cells (125, 126).…”

Section: Ae Studies With Antibodies To Intracellular Antigensmentioning

confidence: 99%

Advances in Autoimmune Epilepsy Associated with Antibodies, Their Potential Pathogenic Molecular Mechanisms, and Current Recommended Immunotherapies

et al. 2017

View full text Add to dashboard Cite

In this comprehensive article, we present an overview of some most common autoimmune antibodies believed to be potentially pathogenic for autoimmune epilepsies and elaborate their pathogenic mode of action in molecular levels based on the existing knowledge. Findings of the studies of immunemodulatory treatments for epilepsy are also discussed, and guidelines for immunotherapy are sorted out. We aim to summarize the emerging understanding of different pathogenic mechanisms of autoantibodies and clinical immunotherapy regimens to open up therapeutic possibilities for future optimum therapy. We conclude that early diagnosis of autoimmune epilepsy is of great significance, as early immune treatments have useful disease-modifying effects on some epilepsies and can facilitate the recovery.

show abstract

“…En pratique, peu de cas de la littérature répon-dent à ce critère. On trouve avant tout des observations isolées de maladie du motoneurone périphérique, de neuropathie avec vascularite, de polyradiculonévrites chroniques [4], de chorées [5,6] ou d'opsomyoclonus [6], mais aussi des tableaux de syndromes paranéoplasiques classiques avec ou sans anticorps onconeuraux.…”

Section: Syndrome Neurologique Qui S'améliore Avec Le Traitement Du Cunclassified

Syndromes neurologiques paranéoplasiques

Antoine

Camdessanché

2007

La Presse Médicale

View full text Add to dashboard Cite

Response to cancer therapy in a patient with a paraneoplastic choreiform disorder

Cited by 38 publications

References 7 publications

Chorea and related movement disorders of paraneoplastic origin: the PNS EuroNetwork experience

Chorea and related movement disorders of paraneoplastic origin: the PNS EuroNetwork experience

Advances in Autoimmune Epilepsy Associated with Antibodies, Their Potential Pathogenic Molecular Mechanisms, and Current Recommended Immunotherapies

Syndromes neurologiques paranéoplasiques

Contact Info

Product

Resources

About