Response surface optimization of experimental conditions for carbamazepine biodegradation by Streptomyces MIUG 4.89

Ungureanu, Claudia Popa; Favier, Lidia; Bahrim, Gabriela; Amrane, Abdeltif

doi:10.1016/j.nbt.2014.12.005

Cited by 39 publications

(25 citation statements)

References 29 publications

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“…In their previous work, Fakhruddin and Quilty (2005) observed the degradation of 2-chlorophenol by Pseudomonas putida CP1 in the culture media supplemented with glucose. Likewise, Strepromyces bacteria isolated from soils cometabolise CLA and carbamazepine in the presence of glucose as additional source of carbon and energy (Popa et al 2014(Popa et al , 2015(Popa et al and 2016.…”

Section: Fig 3 (A) (B)mentioning

confidence: 99%

Successful Biodegradation of a Refractory Pharmaceutical Compound by an Indigenous Phenol-Tolerant Pseudomonas aeruginosa Strain

Hemidouche

Favier

Amrane

et al. 2018

Water Air Soil Pollut

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This study provides an alternative solution for the bioremediation of a recalcitrant pharmaceutical micropollutant. Clofibric acid (CLA) was chosen as target molecule, because of its environmental persistence and resistance to wastewater treatment technologies. The aim of this study was to investigate the potential of a phenol resistant Pseudomonas aeruginosa strain isolated from the activated sludge to degrade CLA. In order to evaluate the effect of acclimation process with glucose as carbon co-substrate, two protocols were carried out, in which the transfer of the inoculum is carried out either in the exponential growth phase or in the decline phase. The results showed a removal efficiency of CLA of 35% when cells in the decline phase were used for inoculation. In contrast, a very low removal yield (10%) was achieved when cells harvested in the exponential phase were used as inoculum. This work is the first one reporting on the capability of this bacterium to remove this drug. The obtained data showed that the isolated strain is able to degrade target molecule and might be a promising agent for the elimination of this refractory compound.

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Section: Fig 3 (A) (B)mentioning

confidence: 99%

Successful Biodegradation of a Refractory Pharmaceutical Compound by an Indigenous Phenol-Tolerant Pseudomonas aeruginosa Strain

Hemidouche

Favier

Amrane

et al. 2018

Water Air Soil Pollut

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“…Traditional method, for example, one-variable-at-a-time, is not suitable for optimizing this process due to so many factors and their interactions between different variables. For example, in some cases of process optimization by RSM, the obtained response surfaces were slopes, and only local optimum (not the global optimum) was achieved in the boundary conditions of experimental design [15,22]. Recently the reports concerning the application of RSM for optimizing the protein PEGylation process are very limited [21].…”

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confidence: 99%

“…However, statistical methods are largely dependent on the design of experiments, which would not achieve the global optimum if the experimentally designed ranges of the variables did not include the optimal conditions. For example, in some cases of process optimization by RSM, the obtained response surfaces were slopes, and only local optimum (not the global optimum) was achieved in the boundary conditions of experimental design [15,22]. Beside the statistical methods, a reaction kinetic model-based approach has been developed for the optimization of protein PEGylation process in our previous reports, which can provide detailed information about the PE-Gylation mechanism, and also achieve the global optimum of the PEGylation process in a very wide range of the variables [9,10].…”

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confidence: 99%

Combined optimization of N‐terminal site‐specific PEGylation of recombinant hirudin using response surface methodology and kinetic analysis

Wang

Pan

et al. 2018

Engineering in Life Sciences

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In this study, a combined optimization method was developed to optimize the N‐terminal site‐specific PEGylation of recombinant hirudin variant‐2 (HV2) with different molecular weight mPEG‐propionaldehyde (mPEG‐ALD), which is a multifactor‐influencing process. The HV2‐PEGylation with 5 kDa mPEG‐ALD was first chosen to screen significant factors and determine the locally optimized conditions for maximizing the yield of mono‐PEGylated product using combined statistical methods, including the Plackett–Burman design, steepest ascent path analysis, and central composition design for the response surface methodology (RSM). Under the locally optimized conditions, PEGylation kinetics of HV2 with 5, 10, and 20 kDa mPEG‐ALD were further investigated. The molar ratio of polyethylene glycol to HV2 and reaction time (the two most significant factors influencing the PEGylation efficiency) were globally optimized in a wide range using kinetic analysis. The data predicted by the combined optimization method using RSM and kinetic analysis were in good agreement with the corresponding experiment data. PEGylation site analysis revealed that almost 100% of the obtained mono‐PEGylated‐HV2 was modified at the N‐terminus of HV2. This study demonstrated that the developed method is a useful tool for the optimization of the N‐terminal site‐specific PEGylation process to obtain a homogeneous mono‐PEGylated protein with desirable yield.

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“…The effect of four different parameters namely the malt culms flour percentage, the salt percentage, the fermentation temperature and its time extension on two of the most important dough quality (deformation and total titratable acidity) were followed. The Response Surface Methodology, an assembly of mathematical and statistical techniques (Madi-Azegagh et al, 2018;Popa et al, 2015a;Popa et al, 2015b;Simion et al, 2017), was employed to analyze the obtained experimental data in order to establish mathematical models able to allow the determination of optimal values for the studied parameters. The obtained dough was baked and the porosity, resilience and total titratable acidity of the resulting bread were analyzed.…”

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confidence: 99%

Application of response surface methodology to optimize some fermentation and formulation conditions of wheat dough fortified with malt culms flour

Simion

Grigoraș

Favier

et al. 2020

Ann.UDJG.FoodTechnology

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The effect of four different parameters namely the malt culms flour addition, the salt percentage, the fermentation period and temperature on two quality indicators of bread dough: deformation and total titratable acidity was analyzed and interpreted by response surface methodology. The optimization of the imposed experimental conditions led to a quality dough characterized by 23.86 % deformation and 2.64 mL NaOH 0.1 N total titratable acidity. These values were obtained using wheat flour with addition of 7.4 % malt culms flour and salt in a quantity of 2.25 % compared to the total amount of flour. The dough was subjected to fermentation for 43 minutes at a temperature of 36 °C. The bread obtained after baking presented similar organoleptic characteristics to those registered for the white bread its increased nutrient intake recommending its consumption for an equilibrated diet.

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Response surface optimization of experimental conditions for carbamazepine biodegradation by Streptomyces MIUG 4.89

Cited by 39 publications

References 29 publications

Successful Biodegradation of a Refractory Pharmaceutical Compound by an Indigenous Phenol-Tolerant Pseudomonas aeruginosa Strain

Successful Biodegradation of a Refractory Pharmaceutical Compound by an Indigenous Phenol-Tolerant Pseudomonas aeruginosa Strain

Combined optimization of N‐terminal site‐specific PEGylation of recombinant hirudin using response surface methodology and kinetic analysis

Application of response surface methodology to optimize some fermentation and formulation conditions of wheat dough fortified with malt culms flour

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