Response-Surface Modeling and Experimental Design

Walmsley, Anthony D.; Stoyanov, Kalin

doi:10.1201/9781420018301.ch8

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…The parameters pH and eluent type were optimized according to the one factor at a time procedure in batch experiments. On the other hand, a chemometric tool [ 24 ] was utilized to optimize variables for sorption (flow rate, volume, and amount of sorbent) and elution (flow rate, eluent volume, and concentration). As demonstrated in Table 2 , the central composite design was performed in five levels to estimate the significance of the effects of variables for sorption and elution, separately.…”

Section: Methodsmentioning

confidence: 99%

Schiff base functionalized silica gel for simultaneous separation and preconcentration of Cu(II), Ni(II), and Cd(II) in pharmaceuticals and water samples

TOKAY¹,

BAĞDAT²

2022

Turkish Journal of Chemistry

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A method for separation and preconcentration of Cu(II), Ni(II), and Cd(II) using N-N′-bis(5-methoxsalicylidene)-2-hydroxy-1,3-propanediamine modified silica gel was improved for aqueous samples and pharmaceuticals. Determination of the analytes was achieved by inductively coupled plasma optic emission spectrometry. The experimental conditions including pH value, sample volume, eluent type and volume, sorbent mass, sample, and eluent flow rates were optimized with univariate and multivariate optimization tools. The relative standard deviations of the method were 2.9% for Cu(II), 3.0% for Ni(II), and 3.3% for Cd(II) with recovery values between 98.8 ± 3.2–101.5 ± 3.0%. The limits of detection were found to be 62.4, 39.5, and 28.2 ng L −1 for Cu(II), Ni(II), and Cd(II), respectively. The accuracy of the suggested procedure was tested with the certified reference material (Certipur ICP multi-element standard solution IV) and addition-recovery experiments. The method was successfully applied to eye drop, anesthetic, serum, tap water, mineral water, and spring water samples.

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Section: Methodsmentioning

confidence: 99%