Response surface methodology optimized dispersive liquid–liquid microextraction coupled with UV-Vis spectrophotometry for determination of quinine

Sereshti, Hassan; Aliakbarzadeh, Ghazaleh

doi:10.1039/c3ay40478a

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…Interestingly, as the concentration of CsCl increased, we observed that the pH of the system moderately increased until it reached 300 mM and subsequently flat lined without surpassing pH 4.8 (650 mM being the maximum concentration tested) (Figure d). This noticeable increase in observed pH can be explained by the Debye–Huckel equation, whereby increasing the ionic concentration of a solution decreases the activity of the hydrogen ions, not the actual content − (Figure m). The observed pH phenomena raised a larger issue regarding the extraneous amount of CsCl needed to reduce the activity of hydrogen ions in a nonbuffered environment by a few units.…”

Section: Resultsmentioning

confidence: 97%

Nano-Cesium for Anti-Cancer Properties: An Investigation into Cesium Induced Metabolic Interference

Daza

Misra

Schwartz-Duval

et al. 2016

ACS Appl. Mater. Interfaces

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The use of cesium chloride (CsCl) for cancer therapy ("high pH therapy") has been theorized to produce anticancer properties by raising intracellular pH to induce apoptosis. Although considered as "alternative medicine", little scientific evidence supports this theory. Alternatively, cells have no cesium ion (Cs) mediated channels for clearance. Thus, such unstable electrochemical distributions have the severe potential to disrupt electrochemical dependent cellular processes, such as glucose cotransporters. Hence, a detailed investigation of pH changing effects and glucose uptake inhibition are warranted as a possible cesium-induced anticancer therapy. We developed and characterized cesium nanoparticles (38 ± 6 nm), termed NanoCs, for nanoparticle-mediated internalization of the ion, and compared its treatment to free CsCl. Our investigations suggest that neither NanoCs nor CsCl drastically changed the intracellular pH, negating the theory. Alternatively, NanoCs lead to a significant decrease in glucose uptake when compared to free CsCl, suggesting cesium inhibited glucose uptake. An apoptosis assay of observed cell death affirms that NanoCs leads tumor cells to initiate apoptosis rather than follow necrotic behavior. Furthermore, NanoCs lead to in vivo tumor regression, where H&E analysis confirmed apoptotic cell populations. Thus, NanoCs performed pH-independent anticancer therapy by inducing metabolic stasis.

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Section: Resultsmentioning

confidence: 97%

Nano-Cesium for Anti-Cancer Properties: An Investigation into Cesium Induced Metabolic Interference

Daza

Misra

Schwartz-Duval

et al. 2016

ACS Appl. Mater. Interfaces

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“…42 Dispersive liquid−liquid microextraction coupled with UV−visible spectrophotometry was applied for the determination of quinine. 43 The critical factors were optimized using CCD and desirability function. Hantzsch condensation reaction was utilized in the development of the spectrophotometric method for the determination of midodrine hydrochloride in oral samples.…”

Section: Introductionmentioning

confidence: 99%

“…The CCD statistical method was applied in the optimization of magnetic extraction for the determination of antidepressants in biological samples . Dispersive liquid–liquid microextraction coupled with UV–visible spectrophotometry was applied for the determination of quinine . The critical factors were optimized using CCD and desirability function.…”

Section: Introductionmentioning

confidence: 99%

Experimental Design Approach in the Optimization of Potentiometric Method for Lansoprazole Determination Using Lansoprazole-Tungstate Based Ion-Selective Electrode

Rahman

Khan

2018

Ind. Eng. Chem. Res.

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The PVC membrane immobilized with lansoprazole-tungstate and plasticized with dioctyl phthalate was characterized by FTIR, XRD, and SEM. The effects of critical parameters such as response time, pH, and temperature on the potential were analyzed, and these were optimized using central composite design (CCD) and desirability function. Under the optimized conditions, the plot of measured potential against concentration of lansoprazole exhibited linearity from 2 × 10–5 to 2 × 10–3 mol L–1 at pH 4.4. The slope of the plot and detection limit was −41.50 mV/decade and 1.57 × 10–5 mol L–1, respectively. The response time of the proposed ion-selective electrode was ≤30 s. The electrode exhibited good selectivity for lansoprazole over a number of ionic species, commonly found in commercial dosage forms. The response mechanism was also discussed. The proposed ion-selective electrode was successfully applied for potentiometric determination of lansoprazole.

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“…[30] To preventt he overuseo fq uinine in beverages and medications, U.S. Food and Drug Administration (FDA) hast herefore established at hreshold dose of 83 ppm for human consumption. [31] As such, it is of utmost importance to be able to easily detecta nd quantify the amount of quinine in common beverages and pharmaceutical products, in af ast and low-cost protocol, as an alternative to traditional methods including chromatography, [32,33] spectrophotometry [34] ,a nd fluorescences pectroscopy, [35,36] whicha re more expensive, time consuming, and not suitable for in situ determinations.…”

Section: Introductionmentioning

confidence: 99%

Chemically Reduced Graphene Oxide for the Assessment of Food Quality: How the Electrochemical Platform Should Be Tailored to the Application

Chng

Ambrosi

Chua

et al. 2017

Chemistry A European J

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Graphene platforms have been drawing considerable attention in electrochemistry for the detection of various electroactive probes. Depending on the chemical composition and properties of the probe, graphene materials with diverse structural features may be required to achieve an optimal electrochemical performance. This work comprises a comparative study on three chemically modified graphenes, obtained from the same starting material and with different oxygen functionalities and structural defects (graphene oxide (GO), chemically reduced graphene oxide (CRGO), and thermally reduced graphene oxide (TRGO)) towards the electrochemical detection of quinine, an important flavoring agent present in tonic-based beverages. In general, the reduced graphenes, namely CRGO and TRGO, showed enhanced performance in terms of calibration sensitivity and selectivity, due to the improved heterogeneous electron-transfer rates on their surfaces. In particular, CRGO provided the best overall electrochemical performance, which can be attributed to its higher density of structural defects and reduced amount of oxygen functionalities. For this reason, CRGO was employed for the electrochemical detection of quinine in commercial tonic drink samples, showing high sensitivity and selectivity, and therefore representing a valid low-cost alternative to more complicated and time consuming traditional analytical methods.

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Response surface methodology optimized dispersive liquid–liquid microextraction coupled with UV-Vis spectrophotometry for determination of quinine

Cited by 9 publications

References 18 publications

Nano-Cesium for Anti-Cancer Properties: An Investigation into Cesium Induced Metabolic Interference

Nano-Cesium for Anti-Cancer Properties: An Investigation into Cesium Induced Metabolic Interference

Experimental Design Approach in the Optimization of Potentiometric Method for Lansoprazole Determination Using Lansoprazole-Tungstate Based Ion-Selective Electrode

Chemically Reduced Graphene Oxide for the Assessment of Food Quality: How the Electrochemical Platform Should Be Tailored to the Application

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