Response: Subclinical Hypothyroidism Is Independently Associated with Microalbuminuria in a Cohort of Prediabetic Egyptian Adults (<i>Diabetes Metab J</i>2013;37:450-7)

El-Eshmawy, Mervat M; El-Hafez, Hala A. Abd; Shabrawy, Walaa Othman El; Aal, Ibrahim A. Abdel

doi:10.4093/dmj.2014.38.1.85

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Previous work indicated that HOMA-IR was higher in diabetic subjects with SCH than in those with normal thyroid function [ 26 ]. El-Eshmawy et al [ 27 ] also revealed positive correlations between TSH levels and HOMA-IR. Interestingly, there are the opposite results were reported.…”

Section: Discussionmentioning

confidence: 95%

Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus

Cho

Kim

Lee

et al. 2016

Korean J Intern Med

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Background/Aims:Overt hypothyroidism is frequently found in patients with type 2 diabetes mellitus (T2DM), but it remains unknown the relationship between subclinical hypothyroidism (SCH) and T2DM. We attempt to evaluate the difference in prevalence of SCH between patients with T2DM and general population, and the association between SCH and glycemic control status ofdiabetic patients.Methods:This was cross-sectional study. Total 8,528 subjects who visited for health check-up were recruited. SCH was defined as an elevated level of serum thyroid stimulating hormone (> 4.0 mIU/L) with a normal level of free thyroxine. T2DM group was categorized into three groups by glycosylated hemoglobin (HbA1c): < 7% (reference), ≥ 7% and < 9%, ≥ 9%.Results:Finally, 7,966 subjects were included. The prevalence of SCH was not different between healthy controls and subjects with T2DM (8.1% vs. 7.4%, p = 0.533; in men, 5.7% vs. 5.1%, p = 0.573; in women, 10.9% vs. 11.7%, p = 0.712), but it was increased with highest HbA1c group more than well controlled group, especially in women. The risk of SCH was increased by group with poorer glycemic control; the odds ratio for HbA1c ≥ 9% compared to < 7% was 2.52 (95% confidence interval [CI], 1.09 to 5.86; p = 0.031), and 4.58 (95% CI, 1.41 to 14.87; p = 0.011) in women, but not significant in men.Conclusions:The prevalence of SCH was similar between T2DM and healthy group. Poor glycemic control in T2DM was obviously associated with the risk of SCH, especially in elderly women. These results suggest SCH as comorbidity may be considered in elderly women with poor glycemic control.

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Section: Discussionmentioning

confidence: 95%

Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus

Cho

Kim

Lee

et al. 2016

Korean J Intern Med

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“…Overt and subclinical hypothyroidism (SCH) may lead to renal dysfunction via decreased GFR as well as to alterations in heart and vascular function and derangements in the renin-angiotensin system [6–8]. Several clinical studies [9, 10] have reported that SCH is also associated with the development of both DN and microalbuminuria. In addition, some prospective studies [11, 12] have shown that levothyroxine (LT4) treatment can significantly decrease the urinary albumin-to-creatinine ratio (UAER) and has protective effects on the kidneys in patients with both DN and SCH.…”

Section: Introductionmentioning

confidence: 99%

Association between thyroid function and diabetic nephropathy in euthyroid subjects with type 2 diabetes mellitus: a cross-sectional study in China

Wang

Tan

et al. 2019

Oncotarget

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Previous studies have suggested that even in euthyroid subjects, thyroid function may affect the risk factors of diabetic nephropathy (DN). Thus, we investigated the association between thyroid parameters and DN in euthyroid subjects with type 2 diabetes mellitus (T2DM). This was a cross-sectional study of 1,071 euthyroid subjects with T2DM (mean age of 61.90 ± 12.74 years; 622 men). Clinical factors, including levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroid autoantibodies, albumin excretion rate were measured. DN was present in 400 (37.35%) individuals. Patients with DN exhibited higher serum TSH and lower serum FT3 and FT4 levels than those without DN (P<0.05). After adjusting traditional risk factors of DN, the levels of both FT3 (per-SD increase, odds ratio [OR] 0.606 [95% confidence interval (CI), 0.481–0.762], P<0.001) and FT4 (per-SD increase, OR 0.944 [0.894–0.998], P = 0.040) were inversely correlated with DN. Meanwhile, we found that serum TSH levels were positively correlated with DN (per-SD increase, OR1.179 [1.033–1.346], P = 0.015). Low-to-normal thyroid hormones (THs) were also associated with the presence of macroalbuminuria. In conclusion, the relatively low levels of THs were significantly associated with DN in euthyroid subjects with T2DM.

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“…6,7,8 Several studies suggested. 9,10 That subclinical hypothyroidism is associated with evolution of microalbuminuria and DN. Many recent studies reported that low to normal thyroid hormones are linked with risk factors of DN like endothelial function, plasma lipid levels 7 hypertension.…”

Section: Introductionmentioning

confidence: 99%

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2019

MIJOBIO

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Background: Diabetic nephropathy due to diabetes is a major cause of end-stage renal disease. It is defined as raised urinary albumin excretion in absence of other kidney diseases that may increase risk of death, especially from cardiovascular causes. Thyroid dysfunction can have effect on development of diabetic nephropathy that have not been studied in a widespread way in India. Purpose is to compare subclinical hypothyroidism (SCH) with renal function in persons with type 2 diabetes mellitus (T2DM). Methods: In all the selected 215 subjects of type 2 diabetes mellitus, thyroid function screening was done by using ELFA method. These subjects were divided into two groups including T2DM with SCH (Group A) and T2DM without SCH (Group B). In all these subjects kidney function was assessed by estimating serum creatinine by Jaffe's method and confirmation was done by eGFR using ID-MS traceable MDRD equation. Results: Significant difference between serum TSH, serum creatinine and eGFR was observed between the above said groups. Conclusion: Type 2 diabetic subjects with SCH can result in DN when compared to those without SCH and those with normal thyroid function.

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Response: Subclinical Hypothyroidism Is Independently Associated with Microalbuminuria in a Cohort of Prediabetic Egyptian Adults (Diabetes Metab J2013;37:450-7)

Cited by 4 publications

References 2 publications

Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus

Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus

Association between thyroid function and diabetic nephropathy in euthyroid subjects with type 2 diabetes mellitus: a cross-sectional study in China

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