Response properties of trigeminal brain stem neurons with input from dura mater encephali in the rat

Schepelmann, Karsten; Ebersberger, Andrea; Pawlak, Maciej; Oppmann, M; Meßlinger, Karl

doi:10.1016/s0306-4522(98)00423-0

Cited by 97 publications

(90 citation statements)

References 82 publications

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“…Von Frey thresholds within dural receptive fields were 0.9 Ϯ 0.3 mN. All units also had lowthreshold facial receptive fields predominantly in the ophthalmic region, as has been found in previous studies (Schepelmann et al, 1999). Increasing the pressure stimuli into the noxious range or pinching the facial receptive fields with sharp forceps caused considerable increases in neuronal activity, revealing the wide dynamic range character of all units.…”

Section: General Properties Of Unitssupporting

confidence: 82%

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The Nonpeptide Calcitonin Gene-Related Peptide Receptor Antagonist BIBN4096BS Lowers the Activity of Neurons with Meningeal Input in the Rat Spinal Trigeminal Nucleus

Fischer¹,

Koulchitsky²,

Meßlinger³

2005

J. Neurosci.

124

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Calcitonin gene-related peptide (CGRP) has been suggested to play a major role in the pathogenesis of migraines and other primary headaches. CGRP may be involved in the control of neuronal activity in the spinal trigeminal nucleus (STN), which integrates nociceptive afferent inputs from trigeminal tissues, including intracranial afferents. The activity of STN neurons is thought to reflect the activity of central trigeminal nociceptive pathways causing facial pain and headaches in humans.In a rat model of meningeal nociception, single neuronal activity in the STN was recorded. All units had receptive fields located in the exposed parietal dura mater. Heat and cold stimuli were repetitively applied to the dura in a fixed pattern of ramps and steps. The nonpeptide CGRP receptor antagonist BIBN4096BS was topically applied onto the exposed dura or infused intravenously. BIBN4096BS (300 g/kg, i.v.) reduced spontaneous activity by ϳ30%, the additional dose of 900 g/kg intravenously by ϳ50% of the initial activity, whereas saline had no effect. The activity evoked by heat ramps was also reduced after BIBN4096BS (900 g/kg, i.v.) by ϳ50%. Topical administration of BIBN4096BS (1 mM) did not significantly change the spontaneous neuronal activity within 15 min.We conclude that the endogenous release of CGRP significantly contributes to the maintenance of spontaneous activity in STN neurons. Blockade of CGRP receptors, possibly at central and peripheral sites, may therefore be an effective way to decrease nociceptive transmission. This may offer a new therapeutic strategy for the treatment of facial pain and primary headaches.

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Section: General Properties Of Unitssupporting

confidence: 82%

“…Male Wistar rats with body weights ranging from 300 to 480 g were used. Details of the surgical and recording procedures have been described previously (Schepelmann et al, 1999;Koulchitsky et al, 2004). Briefly, rats were anesthetized with an initial intraperitoneal dose of 120 -150 mg/kg thiopentone (Trapanal; Byk Gulden, Konstanz, Germany).…”

Section: Methodsmentioning

confidence: 99%

The Nonpeptide Calcitonin Gene-Related Peptide Receptor Antagonist BIBN4096BS Lowers the Activity of Neurons with Meningeal Input in the Rat Spinal Trigeminal Nucleus

Fischer¹,

Koulchitsky²,

Meßlinger³

2005

J. Neurosci.

124

View full text Add to dashboard Cite

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“…Local anesthesia of either the ocular surface or nasal cavity (Gupta et al, 1997) reduced aqueous tear production. A high percentage of type II Vi/Vc units (22 of 25 tested) received convergent inputs from the ocular surface and nasal muscosa (this study), whereas nearly all Vi/Vc units driven by dural membrane stimulation were driven by corneal input (Schepelmann et al, 1999). The Vi/Vc transition has been implicated in the control of eye-blink reflexes (Pellegrini et al, 1995;Zerari-Mailly et al, 2003), and this may be one function for type I corneal units that projected to the SSN-facial motor nucleus region but were not moisture sensitive ; this study).…”

Section: Discussionmentioning

confidence: 56%

A Novel Class of Neurons at the Trigeminal Subnucleus Interpolaris/Caudalis Transition Region Monitors Ocular Surface Fluid Status and Modulates Tear Production

Hirata¹,

Okamoto²,

Tashiro³

et al. 2004

J. Neurosci.

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“…It is worth noting that the relatively high level of baseline spontaneous activity we recorded is likely to be caused by the type of electrodes we used. Other studies investigating the spontaneous activity of dural-responsive neurons recorded with carbon or stainlesssteel electrodes (impedance, 8 -12 M⍀) reported considerably lower spontaneous activity (0.05-46 Hz) as a result of the different spatial-recruitment characteristics of the electrodes (Burstein et al, 1998;Schepelmann et al, 1999). -agatoxin IVA is an irreversible blocker of P/Q-type calcium channels (Mintz et al, 1992); however, it also has a small effect on T-type channels in some cells (Rusin and Moises, 1995), depending on the concentration of agatoxin at the synapse.…”

Section: Discussionmentioning

confidence: 99%

P/Q-Type Calcium-Channel Blockade in the Periaqueductal Gray Facilitates Trigeminal Nociception: A Functional Genetic Link for Migraine?

Knight¹,

Bartsch²,

Kaube³

et al. 2002

J. Neurosci.

178

115

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The discovery of mis-sense mutations in the ␣1A subunit of the P/Q-type calcium channel in patients with familial hemiplegic migraine indicates the potential involvement of dysfunctional ion channels in migraine. The periaqueductal gray (PAG) region of the brainstem modulates craniovascular nociception and, through its role in the descending pain modulation system, may contribute to migraine pathophysiology. In this study we sought to investigate the possible link between the genetic mutations found in migraineurs and the PAG as a modulator of craniovascular nociception. We microinjected the P/Q-type calciumchannel blocker -agatoxin IVA into the rat ventrolateral PAG (vlPAG). We examined its effect on the nociceptive transmission of second-order neurons recorded in the trigeminal nucleus caudalis and activated by stimulation of the parietal dura mater. After injection of agatoxin into the vlPAG (n ϭ 20) responses to dural stimulation were facilitated by 143% ( p Ͻ 0.0001) for A␦-fiber activity and 180% for C-fiber activity ( p Ͻ 0.05). Similarly, spontaneous background activity increased by 163% ( p Ͻ 0.0001). These results demonstrate that P/Q-type calcium channels in the PAG play a role in modulating trigeminal nociception and suggest a role for dysfunctional P/Q-type calcium channels in migraine pathophysiology.

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Response properties of trigeminal brain stem neurons with input from dura mater encephali in the rat

Cited by 97 publications

References 82 publications

The Nonpeptide Calcitonin Gene-Related Peptide Receptor Antagonist BIBN4096BS Lowers the Activity of Neurons with Meningeal Input in the Rat Spinal Trigeminal Nucleus

The Nonpeptide Calcitonin Gene-Related Peptide Receptor Antagonist BIBN4096BS Lowers the Activity of Neurons with Meningeal Input in the Rat Spinal Trigeminal Nucleus

A Novel Class of Neurons at the Trigeminal Subnucleus Interpolaris/Caudalis Transition Region Monitors Ocular Surface Fluid Status and Modulates Tear Production

P/Q-Type Calcium-Channel Blockade in the Periaqueductal Gray Facilitates Trigeminal Nociception: A Functional Genetic Link for Migraine?

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