Response of tissue electrolytes to respiratory acidosis

Abstract

The effect of 8% CO2 for 24 hr on the electrolyte composition of muscle, bone, and liver has been studied in rats on a normal diet as well as on one low in sodium and low in potassium. Muscle potassium decreased in animals on a normal or low-sodium diet exposed to CO2. Muscle sodium decreased in animals on a low-potassium diet exposed to CO2, and there was no further change in the already low levels of muscle potassium. The sodium and potassium content of bone and liver and the calcium content of bone were unchanged by exposure to CO2. Nephrectomy blocks the loss of muscle potassium noted in rats on a normal diet. Muscle and bone sodium were also unaltered by CO2 in nephrectomized rats. These results contrast with those obtained during metabolic acidosis and emphasize the importance of the kidneys in bodily adjustments to respiratory acidosis.

Chloride Depletion and Hypochloraemia as a Cause of Renal Sodium and Water Loss in the Rat

“…Urinary and plasma osmolality were measured by an Advanced osmometer and packed cell volume by an Autocrit centrifuge. Methods for muscle (Levitin, Amick & Epstein, 1961) and papillary (Mannitus, Levitin, Beck & Epstein, 1960) nitric acid extraction for measurement of sodium and potassium content were as previously described. The two papillae from each rat were taken for analysis; wet weight was in the range 10-12 mglrat.…”