Response of the Sensitized Heart to Oxidized and Reduced Streptolysin O

Prager, Denis J.; Feigen, George A.

doi:10.1159/000230270

Cited by 5 publications

(1 citation statement)

References 15 publications

(16 reference statements)

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“…the sequence of the two events always remained constant. The demonstration [12] that the first phase could be selectively extinguished by atropine and the second phase by pyribenzamine suggested that the sequential responses came about from the atrial reaction to the two antagonistically acting mediators. The fact that one molecular probe could release two antagonistically acting agents raised important fundamenal questions in immunopharmacology, and the fact that a single molecu lar species could be selectively turned on to release either one or two mediators sug gested the 'double agent' approach as a useful general technique to their solution.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Biphasic Response in Cardiac Anaphylaxis to an Active Streptococcal Toxin

Feigen

Conrad

Gerber

et al. 1974

Int Arch Allergy Immunol

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Guinea pig atria, sensitized in vitro with rabbit anti-streptolysin O, release histamine when challenged with inactive toxin and both histamine and acetylcholine when tested with the active (reduced) form. Challenge with active toxin results in a transient cholinergic depressor reaction which precedes the long-lasting augmentor effect of histamine. This biphasic response was analyzed by (1) varying the intensity of the anaphylactic phase alone, (2) by activating the toxin in the reaction system after initiating anaphylaxis by inactive toxin, and (3) by simulation of the biphasic response, using the mediators themselves. When the atrium is presented both substances simultaneously, the response to acetylcholine precedes that to histamine. The powerful atrial cholinesterase activity explains the transience of the toxic phase. The transient and oppositely directed effects of acetylcholine on the cardiac action potential always override those of histamine.

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Section: Introductionmentioning

confidence: 99%

Analysis of the Biphasic Response in Cardiac Anaphylaxis to an Active Streptococcal Toxin

Feigen

Conrad

Gerber

et al. 1974

Int Arch Allergy Immunol

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The Schultz-Dale reaction: A review

Chand

Eyre

1978

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Vascular (pulmonary and hepatic blood vessels) and nonvascular (gastro-intestinal, reproductive and respiratory systems) smooth muscle preparations obtained from specifically sensitized animals of numerous species including man contract to specific antigen in vitro (Schultz-Dale phenomenon). This immunopharmacological technique is a useful tool to demonstrate immediate-type hypersensitivity in actively or passively sensitized tissues and may be used to investigate the nature of the principal pharmacological mediators involved in a particular tissue as well as to screen anti-anaphylactic (anti-allergic) drugs. However, much remains to be investigated on the complex mechanisms of action of antigen, desensitization and resensitization (recovery) of anaphylactic responsiveness.

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Experimental cardiac anaphylaxis

Feigen

Prager

1969

The American Journal of Cardiology

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Response of the Sensitized Heart to Oxidized and Reduced Streptolysin O

Cited by 5 publications

References 15 publications

Analysis of the Biphasic Response in Cardiac Anaphylaxis to an Active Streptococcal Toxin

Analysis of the Biphasic Response in Cardiac Anaphylaxis to an Active Streptococcal Toxin

The Schultz-Dale reaction: A review

Experimental cardiac anaphylaxis

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