Response of the Retinal Pigment Epithelium to Selective Photocoagulation

Roider, Johann; Michaud, Norman; Flotte, Thomas J.; Birngruber, Reginald

doi:10.1001/archopht.1992.01080240126045

Cited by 179 publications

(156 citation statements)

References 21 publications

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“…6 Incompetent retinal vessels regain potency when the outer blood-retinal barrier is repaired after laser therapy. 4 These observations suggest that the laser scar that forms after photocoagulation may be a source of factors that restore leaking retinal vessels. RPE and Müller cells react to tissue destruction by assembling at the site in the immediate and early phases, suggesting that they play an important role in repair of the outer blood-retinal barrier.…”

Section: Discussionmentioning

confidence: 99%

“…Changes in retinal morphology after laser have been well described in rats, 3 rabbits, 4 monkeys, 5 and humans. 6 7 Although some laser energy may directly affect the retinal vessels, it is generally accepted that the major site of absorption is the RPE and choroid.…”

mentioning

confidence: 99%

“…6 7 Although some laser energy may directly affect the retinal vessels, it is generally accepted that the major site of absorption is the RPE and choroid. 6 The laser affected areas of the photoreceptor outer segments and RPE exhibit signs of necrosis including cell disruption, vacuolisation, and condensation of cytoplasmic proteins within a few hours after treatment 4 to an extent that is commensurate with the intensity of the burn. 5 Within days, RPE cells migrate across Bruch's membrane to fill the lesion with subsequent scar formation.…”

mentioning

confidence: 99%

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Conditioned medium from mixed retinal pigmented epithelium and Muller cell cultures reduces in vitro permeability of retinal vascular endothelial cells

Tretiach¹

2004

British Journal of Ophthalmology

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Aim: To investigate the in vitro effect of laser photocoagulation on blood-retinal barrier permeability. Methods: Retinal capillary endothelial cells were exposed to supernatants from long term co-cultured cells that were argon laser treated. Endothelial cell permeability was analysed by (1) measurement of transendothelial electrical resistance and (2) Results: Laser photocoagulation of various retinal cells and control ECV304 cells in the lower chamber did not appreciably improve permeability of the endothelial cell monolayer compared with that of unlasered cells. However, medium that was conditioned by mixed retinal pigmented epithelium and Müller cells significantly reduced both inulin (43.2% (SD 6.5%) equilibration in mixed cultures v 59.8% (SD 7.0%) control cells, p,0.05) and albumin (15.1% (SD 3.8%) v 31.1% (SD 6.7%), p,0.05) permeability of the endothelial cell monolayers. A fourfold increase in transendothelial electrical resistance was also seen. Conclusions: These results are consistent with the hypothesis that interaction of Müller cells with retinal pigmented epithelium induced by laser treatment results in secretion of soluble factor(s), which reduces permeability of retinal vascular endothelium. Identification of these factor(s) may have implications for the clinical treatment of macular oedema secondary to diabetic retinopathy and other diseases.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Conditioned medium from mixed retinal pigmented epithelium and Muller cell cultures reduces in vitro permeability of retinal vascular endothelial cells

Tretiach¹

2004

British Journal of Ophthalmology

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“…В 1993 году J. Roider et al предложили для лечения диабетического маку-лярного отёка использовать микрофотокоагуляцию (MicroPulse). При микрофотокоагуляции использу-ют минимальные, близкие к порогу повреждения сетчатки уровни мощности лазерного излучения [2,3]. Более поздние исследования D. Lavinsky et al (2011) свидетельствуют об увеличении эффективно-сти микрофотокоагуляции при более плотном на-несении ожогов сетчатки [4,6].…”

Section: актуальностьunclassified

Comparative estimation of laser coagulation efficiency in macular and microphotocoagulation of high density in diabetic maculopathy treatment

Kotsur

Izmaylov

2016

Ophthalmology Reports

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Санкт-Петербургский филиал ФГАУ «МНТК «Микрохирургия глаза» им. акад. С.Н. Фёдорова» Дата поступления: 07.09.2016 Статья принята к печати: 24.11.2016  Субпороговая микрофотокоагуляция (MicroPulse) приводит к появлению плохо различимых или невидимых ожогов сетчатки и зарекомендовала себя как эффективный метод в лечении диабети-ческого макулярного отёка при отсутствии побочных эффектов, свойственных методике ETDRS (атрофия пигментного эпителия и сосудистой оболочки, снижение чувствительности сетчатки). Эффективность микрофотокоагуляции может быть повышена при более плотном нанесении ла-зерных аппликаций, однако в современной литературе этому вопросу посвящены единичные пу-бликации. Ключевые слова: диабетическая макулопатия; диабетическая ретинопатия; сахарный диабет 2-го типа; микрофотокоагуляция; околосубпороговая лазерная коагуляция.  Subthreshold microphotocoagulation (MicroPulase) leads to development of barely visible or invisible retinal burns and has been shown to be effective in macular edema treatment without any side effects inherent to the ETDRS method (atrophy of retinal pigment epithelium and choroid, decrease of retinal sensitivity). Microphotocoagulation efficacy may be increased by high density laser applications, however in modern literature rare publications draw attention to this matter. COMPARATIVE ESTIMATION OF LASER COAGULATION EFFICIENCY IN MACULAR AND MICROPHOTOCOAGULATION OF HIGH DENSITY IN DIABETIC MACULOPATHY TREATMENT

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“…The first RPE-selective retinal laser treatment was achieved using 5 µs argon laser pulses at 514 nm and a repetition rate of 500 Hz [37] .Currently, several microsecond-pulsed laser systems are available [38,39] . Recently, an alternative SRT approach has been developed based on a rapidly scanning continuous wave laser, such that RPE cells are exposed to a scanning laser light to achieve dwell times of a few microseconds [40,41] .…”

Section: Paulus Ym Retinal Lasersmentioning

confidence: 99%

New Frontiers in Selective Retinal Lasers

Paulus¹

2015

International Journal of Ophthalmic Research

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Response of the Retinal Pigment Epithelium to Selective Photocoagulation

Cited by 179 publications

References 21 publications

Conditioned medium from mixed retinal pigmented epithelium and Muller cell cultures reduces in vitro permeability of retinal vascular endothelial cells

Conditioned medium from mixed retinal pigmented epithelium and Muller cell cultures reduces in vitro permeability of retinal vascular endothelial cells

Comparative estimation of laser coagulation efficiency in macular and microphotocoagulation of high density in diabetic maculopathy treatment

New Frontiers in Selective Retinal Lasers

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