“…Bowel perforation is possible with OC, although the overall risk is relatively small for experienced users. Lethal or noxious effects of x-rays are possible but unlikely in microCT; rodents have long been known to be resistant to ionizing radiation (28). It is important to ask whether tumor stasis and regression are caused by the radiologic doses used in the documentation of tumor fate.…”
Rationale and Objectives-The purpose of this study was to evaluate the relative merits of microCT colonography (mCTC) and optical colonoscopy (OC) for longitudinal studies of colonic tumors in mice.
Materials and Methods-Colonic
“…Bowel perforation is possible with OC, although the overall risk is relatively small for experienced users. Lethal or noxious effects of x-rays are possible but unlikely in microCT; rodents have long been known to be resistant to ionizing radiation (28). It is important to ask whether tumor stasis and regression are caused by the radiologic doses used in the documentation of tumor fate.…”
Rationale and Objectives-The purpose of this study was to evaluate the relative merits of microCT colonography (mCTC) and optical colonoscopy (OC) for longitudinal studies of colonic tumors in mice.
Materials and Methods-Colonic
“…The meadow vole has an acute LD 50-30 of 7-8.4 Gy (Iverson and Turner, 1976a) compared to 10-12 Gy in Clethrionomys (Mihok et al, 1985a), and 13 Gy in P. formusus (Gambino and Lindberg, 1964). Yet, no effects were evident when lifetime doses approached the median acute lethal dose for many breeding voles.…”
Section: Chronic Radiation Exposure Of Wild Populations Of Rodentsmentioning
“…Both experiments suggest that the pika is relatively sensitive to ionizing radiation in comparison to other wild mammals (Chang et al , 1964;Golley et al, 1965;Gambino and Lindberg, 1964;Provost et al , 1965) and similar in sensitivity to laboratory mice (Roderick, 1963).…”
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