Response of the left ventricular end-systolic pressure-volume relation in conscious dogs to a wide range of contractile states.

Little, William C.; Cheng, Che‐Ping; Peterson, Tim O.; Vinten-Johansen, J.

doi:10.1161/01.cir.78.3.736

Cited by 124 publications

(39 citation statements)

References 36 publications

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“…9 To describe the position of the end-systolic PV relation, we calculated the volume when P a =100 mmHg (V 100 ). 10 End diastole was taken at the time corresponding to the peak of the R wave of the ECG. The end-diastolic PV relation points during caval occlusion were exponentially fitted by the equation…”

Section: Discussionmentioning

confidence: 99%

“…In addition, we have used the volume axis value at P 100 (V 100 ) as a variable describing the position of the slope of the end-systolic PV relation in the normal operating range of the left ventricle, thus avoiding the problems of interpretation of V o in a range in which curvilinearity of the slope may occur. 10 The following important changes in cardiac performance were observed in the present study during the infusion of Mg 2+ : (1) a reduction in systolic function in a dose-response manner, (2) a rightward shift in the end-diastolic PV relation caused by decreased chamber stiffness in all groups, (3) slowing of LV isovolumic relaxation, and (4) electrophysiological effects in the high-dose Mg 2+ group consisting of sinus bradycardia, decreased atrioventricular conduction, and suppression of sinus node function.…”

Section: = 16mmmentioning

confidence: 99%

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Dose-related effects of magnesium on myocardial function in the neonate.

et al. 1994

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The antagonistic effects of magnesium ion as a calcium ion blocker may decrease calcium influx associated with ischemia. However, the effect of magnesium on the preischemic neonatal myocardium has not been investigated previously. The purpose of this study was to investigate the effects of the administration of increasing doses of magnesium on left ventricular performance in the neonate. We assessed left ventricular function (pressure-volume data obtained by the conductance catheter/micromanometer technique) in three groups (n=6 in each) of newborn pigs (3 to 5 days old) differing with respect to magnesium concentrations. Endsystolic elastance did not change during infusion in group A (magnesium=1.2 mmol/L), whereas in groups B (magnesium=8 mmol/L) and C (magnesium=16 mmol/L) it decreased significantly (P<.05) to 67±6% and 44±8% of baseline, respectively. The decrease in end-systolic elastance was associated with a significant reduction in cardiac output (P<.05) and stroke work (P<.05) in group C. After administration of magnesium, end-systolic elastance returned to baseline in group B in contrast to group C (78±3% of baseline value, P<.05). The slope constant of the end-diastolic pressure-volume relation decreased significantly (P<.05) from the preinfusion baseline values of 0.42±0.08 mL" 1 in group B and 0.46±0.05 mL" 1 in group C to 0.3±0.04 and 0.26±0.03 mL"', respectively, versus no change in group A. At the end of the experiment, the slope constant returned to baseline value in group B, whereas in group C it remained significantly lower (P<.05, 78±3% of baseline). We conclude that administration of 8 to 16 mmol/L magnesium affects the systolic function and alters the diastolic properties of the neonatal heart in a dose-response manner. can affect cardiac contractility and tension development by changing sarcolemmal and membrane binding of Ca 2 + , thus directly affecting resting membrane potentials and excitation-contraction coupling events.2 It is also now clear that small changes in free external Mg 2 + can exert significant effects on cardiac cell mechanical and electrical activities.3 Evidently, Mg 2 + can be considered as a natural Ca 2+ antagonist that may influence and control many cardiovascular functions.The effects of Mg 2 + on cardiovascular hemodynamics were studied mainly in adults.4 -5 However, the effects of Mg 2 + on cardiac mechanics in the intact neonatal or adult heart, using the pressure-volume (PV) relation, have not been studied. Therefore, this study was designed to examine the effects of the administration of varying doses of magnesium sulfate (MgSO 4 ) on left ventricular (LV) systolic and diastolic function in the neonate.

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Section: Discussionmentioning

confidence: 99%

Section: = 16mmmentioning

confidence: 99%

Dose-related effects of magnesium on myocardial function in the neonate.

et al. 1994

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“…Patients underwent routine right and left heart catheterization, (4,13,14). Real-time pressure-volume diagram generation and analog/digital conversion (333 Hz) were performed using a 16-bit microcomputer system (PC-9801VX, NEC Co., Tokyo, Japan).…”

Section: Cardiac Catheterization Proceduresmentioning

confidence: 99%

Hemodynamic Characteristics of Patients with Diastolic Heart Failure and Hypertension

et al. 2008

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“…Ees (mmHg/ml) has been applied to the LV of the intact animal and human as a relatively load-independent index of myocardial contractility. 17,[19][20][21] We normalized Ees (mmHg ml -1 m -2 ) and V0 (ml/m 2 ) for body surface area to permit comparison among patients in the present study, as described previously. 21 …”

Section: Assessment Of LV Contractilitymentioning

confidence: 99%

Beneficial Effects of Heart Rate Reduction on Cardiac Mechanics and Energetics in Patients With Left Ventricular Dysfunction

et al. 1999

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Response of the left ventricular end-systolic pressure-volume relation in conscious dogs to a wide range of contractile states.

Abstract: We assessed the linearity and slope of the left ventricular end-systolic pressure (PES)-volume (VEs) relation over a wide range of contractile states in conscious dogs. The

Cited by 124 publications

References 36 publications

Dose-related effects of magnesium on myocardial function in the neonate.

Dose-related effects of magnesium on myocardial function in the neonate.

Hemodynamic Characteristics of Patients with Diastolic Heart Failure and Hypertension

Beneficial Effects of Heart Rate Reduction on Cardiac Mechanics and Energetics in Patients With Left Ventricular Dysfunction

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