Response of the expression of oxytocin neurons to ghrelin in female mice

Pan, Deng; Fan, Kuikui; Li, Qiang; Liu, Haodong; Li, Penghui; Hai, Rihan; Du, Chunling

doi:10.1007/s00221-020-05793-z

Cited by 4 publications

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“…The PVN is an important regulatory center of neuroendocrine activity and the sympathetic nerve drive, while the hypothalamic ARC is involved in anterior pituitary endocrine function regulation, many metabolic processes, and complex behaviors. Robust staining indicated a marked MC4R expression in the hippocampus, ARC, PBN, NTS, RPa, and AP; expression was also found in the VMH, DMH, and IML, but very little immunoreactivity was found medial to the PVN [22] and brainstem. These patterns agree with a previous study [3,23].…”

Section: Discussionmentioning

confidence: 96%

Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain

et al. 2020

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ObjectiveMelanocortin-4 receptors (MC4Rs) are key regulators of energy homeostasis and adipose deposition in the central nervous system. Considering that MC4R expression regions and function-related research mainly focus on the paraventricular nucleus (PVN), little is known about their distribution throughout the mouse brain, although its messenger RNA distribution has been analyzed in the rat. Therefore, MC4R protein localization in mouse neurons was the focus of this study.MethodsMC4R protein distribution was assessed in mice through immunofluorescence and Western blotting.ResultsMC4R was differentially expressed throughout the arcuate nucleus (ARC), nucleus of the solitary tract (NTS), raphe pallidus (RPa), medial cerebellar nucleus, intermediolateral nucleus, and brainstem. The highest MC4R protein levels were found in the ARC and ventromedial hypothalamic nucleus, while they were significantly lower in the parabrachial nucleus and NTS. The lowest MC4R protein levels were found in the PVN; there was no difference in the protein levels between the area postrema and RPa.ConclusionsThese data provide a basic characterization of MC4R-expressing neurons and protein distribution in the mouse brain and may aid further research on its role in energy homeostasis.

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Section: Discussionmentioning

confidence: 96%

Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain

et al. 2020

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Inhibitory effect of central ghrelin on steroid synthesis affecting reproductive health in female mice

Pan

Wang

Cao

et al. 2020

The Journal of Steroid Biochemistry and Molecular Biology

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Sex differences in fear memory consolidation via Tac2 signaling in mice

et al. 2021

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Memory formation is key for brain functioning. Uncovering the memory mechanisms is helping us to better understand neural processes in health and disease. Moreover, more specific treatments for fear-related disorders such as posttraumatic stress disorder and phobias may help to decrease their negative impact on mental health. In this line, the Tachykinin 2 (Tac2) pathway in the central amygdala (CeA) has been shown to be sufficient and necessary for the modulation of fear memory consolidation. CeA-Tac2 antagonism and its pharmacogenetic temporal inhibition impair fear memory in male mice. Surprisingly, we demonstrate here the opposite effect of Tac2 blockade on enhancing fear memory consolidation in females. Furthermore, we show that CeA-testosterone in males, CeA-estradiol in females and Akt/GSK3β/β-Catenin signaling both mediate the opposite-sex differential Tac2 pathway regulation of fear memory.

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Response of the expression of oxytocin neurons to ghrelin in female mice

Cited by 4 publications

References 45 publications

Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain

Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain

Inhibitory effect of central ghrelin on steroid synthesis affecting reproductive health in female mice

Sex differences in fear memory consolidation via Tac2 signaling in mice

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