Response of the Electrical Activity, Motor Activity and Acid Secretion of the Human Stomach to Pentagastrin and Histamine Stimulation

Abstract

The electrical and motor activity and the acid output of the stomach have been studied in 21 subjects at rest, and during stimulation with pentagastrin or histamine. All three parameters were increased by pentagastrin. Intravenous pentagastrin increased acid output at 0.06 pg/kg/h and electrical and motor activity at 0.6 pg/kg/h. The mean maximal rise in frequency of the electrical activity was 20 per cent. The coupling of the electrical and motor activity was augmented. Histamine increased the acid output but had no effect on electrical or motor activity. G~.~t r~e~t t .6 , 145-153.* Based on a communication to the Surgical Research Society -January 1970. 3-Sciind. J. Gastroenttrum of the stomach, under radiological CODtrol, and the following measurements were made.Electrical activity. A stainless steel electrode, 0.25 m m in diameter, projecting 1 m m above the side opening of a modified nasogastric tube was applied t o the antral mucosa by suction t o 20 c m of mercury, negative pressure. The indifferent electrode was a metal disc applied t o the scarified abdominal skin, coated with a thin layer of electrolyte jelly. Signals from the electrodes were fed t o a n A/C amplifier and recorded o n ultra-violet paper a t a sensitivity of 1 mv/cm. Parallel outputs from the amplifier were fed to a high pass and a low pass filter, and were also displayed.Motor activity. Intragastric pressure changes were recorded via a polyethylene tube of 1 m m internal diameter placed inside the above nasogastric tube, the distal end of the polyethylene tube being brought out opposite the electrode while the proximal end was connected to a Scand J Gastroenterol Downloaded from informahealthcare.com by Chulalongkorn University on 01/02/15For personal use only.

The effects of humoral agents on the myoelectrical activity of the terminal ileum

“…It is of the same order of frequency as in intact man as demonstrated by the records from the implanted electrodes. Subserosal electrodes recorded identical data to mucosal electrodes as has been shown in the stomach and duodenum in man (Kwong, Brown, Whittaker, and Duthie, 1971;Couturier, Roze, Paolaggi, and Debray, 1971). The adaptive change is brought about by a significant reduction in frequency of action potentials.…”

“…Gastrin I and secretin were used to investigate the humoral control of electrical and motor activity of the ileum because of their relative purity and known reliability and in addition they were known to produce electrical and motor changes in the normal stomach (Kwong, Brown, Whittaker, and Duthie, 1971; Monges and Salducci, 1971). The pacesetter potential was noticeably resistant to the effect of both humoral agents in contrast to that of the stomach.…”

The electrical and motor actions of gastrointestinal hormones on the duodenum in man

“…Pentagastrin in doses of 1.0 and 6 ,g/kg hr was given by continuous intravenous infusion to eight patients. Secretin was given by continuous intravenous infusion in separate tests in 0-25 and 1 unit/kg W. E. Waterfall, H. L. Duthie, and B. H. Brown hr doses to six patients.These doses were selected because they produced the maximal effect on myoelectrical activity in the normal human stomach (Kwong et al, 1971b) and in the terminal ileum . Hormones were infused at each dose for a period of 40 minutes.…”

“…However, Kwong, Brown, Whittaker, and Duthie (1971b) demonstrated the potentiation of the pacesetter potential (PSP) and motor waves in the normal human stomach by pentagastrin and the inhibitory effects of secretin. More recently the effects of these two hormones in the terminal ileum in patients with an ileostomy have been reported .…”

Continuous monitoring of the effect of pentagastrin on gastric emptying of solid food in man.

“…(Hunt and Ramsbottom, 1967;Misiewicz et al, 1967;Kelly, 1970;Dozois and Kelly, 1971;Kwong et al, 1971;Cooke et al,1972). Received Composition of meal The meal consisted of 100 g cooked, lean, minced beef and 28 g of a proprietary potato whip (Edgell) added to 125 ml boiling water.…”