Response of the adult newt ventricle to injury

Oberpriller, John O.

doi:10.1002/jez.1401870208

Cited by 364 publications

(260 citation statements)

References 18 publications

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“…These kinds of experiments bear repeating using today's transgenic markers. Intriguingly, newt heart cardiomyocytes, which have the ability to dedifferentiate and regenerate injured heart tissue (Nag, Healy, & Cheng, 1979; Oberpriller & Oberpriller, 1974), dedifferentiated and transdifferentiated to skeletal muscle and chondrocytes when transplanted into the limb regeneration blastema (Laube, Heister, Scholz, Borchardt, & Braun, 2006), suggesting that the blastema environment can exert a powerful influence on cell phenotype that extends beyond limb cells.…”

Section: Blastema Patterning: Autonomous or Induced?mentioning

confidence: 99%

Mechanisms of urodele limb regeneration

Stocum

2017

Regeneration

109

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This review explores the historical and current state of our knowledge about urodele limb regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of limb tissues to release resident stem cells and mononucleate cells that undergo dedifferentiation, cell cycle entry and accumulation under the apical epidermal cap. (2) The origin, phenotypic memory, and positional memory of blastema cells. (3) The role played by macrophages in the early events of regeneration. (4) The role of neural and AEC factors and interaction between blastema cells in mitosis and distalization. (5) Models of pattern formation based on the results of axial reversal experiments, experiments on the regeneration of half and double half limbs, and experiments using retinoic acid to alter positional identity of blastema cells. (6) Possible mechanisms of distalization during normal and intercalary regeneration. (7) Is pattern formation is a self‐organizing property of the blastema or dictated by chemical signals from adjacent tissues? (8) What is the future for regenerating a human limb?

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Section: Blastema Patterning: Autonomous or Induced?mentioning

confidence: 99%

Mechanisms of urodele limb regeneration

Stocum

2017

Regeneration

109

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“…Unlike skeletal muscle, the adult mammalian heart retains only a modest ability to regenerate, contrasting the efficient and scarless healing seen in lower vertebrates, such as newts, axolotls, and zebrafish (Oberpriller and Oberpriller 1974). Perhaps the most compelling evidence of myocardial regeneration in humans comes from 14 C labeling that occurred during the era of aboveground atomic weapon testing (Bergmann et al 2009).…”

Section: Two Roads Diverged In a Wood And I-i Took The One Less Travmentioning

confidence: 99%

BAF60 A, B, and Cs of muscle determination and renewal

Puri

Mercola

2012

Genes Dev.

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Developmental biologists have defined many of the diffusible and transcription factors that control muscle differentiation, yet we still have only rudimentary knowledge of the mechanisms that dictate whether a myogenic progenitor cell forms muscle versus alternate lineages, including those that can be pathological in a state of disease or degeneration. Clues about the molecular basis for lineage determination in muscle progenitors are only now emerging from studies of chromatin modifications that avail myogenic genes for transcription, together with analysis of the composition and activities of the chromatin-modifying complexes themselves. Here we review recent progress on muscle determination and explore a unifying theme that environmental cues from the stem or progenitor niche control the selection of specific subunit variants of the switch/sucrose nonfermentable (SWI/SNF) chromatin-modifying complex, creating a combinatorial code that dictates whether cells adopt myogenic versus nonmyogenic cell fates. A key component of the code appears to be the mutually exclusive usage of the a, b, and c variants of the 60-kD structural subunit BAF60 (BRG1/BRM-associated factor 60), of which BAF60c is essential to activate both skeletal and cardiac muscle programs. Since chromatin remodeling governs myogenic fate, the combinatorial assembly of the SWI/SNF complex might be targeted to develop drugs aimed at the therapeutic reduction of compensatory fibrosis and fatty deposition in chronic muscular disorders.

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“…Urodele amphibians are unique among vertebrates because they retain remarkable regenerative abilities as adults. Adult urodele amphibians can regenerate highly differentiated tissues and organs such as the heart (Oberpriller & Oberpriller, 1974), jaws (Ghosh, Thorogood, & Ferretti, 1996), intestine (O'Steen, 1958), lens (Reyer, 1956), and complex structures such as limbs (Spallanzani, 1768), which is the most surprising because the limb must regenerate a new functionally integrated structure (McCusker & Gardiner, 2014). During the regenerative process, key events have been described, including the formation of a regenerative epithelium and blastema (Iten & Bryant, 1973; Tank, Carlson, & Connelly, 1976).…”

Section: Introductionmentioning

confidence: 99%

Limb regeneration in a direct‐developing terrestrial salamander, Bolitoglossa ramosi (Caudata: Plethodontidae)

et al. 2017

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Appendage regeneration is one of the most compelling phenomena in regenerative biology and is extensively studied in axolotls and newts. However, the regenerative capacity in other families of salamanders remains poorly described. Here we characterize the limb regeneration process in Bolitoglossa ramosi, a direct‐developing terrestrial salamander of the plethodontid family. We (1) describe the major morphological features at different stages of limb regeneration, (2) show that appendage regeneration in a terrestrial salamander varies from other amphibians and (3) show that limb regeneration in this species is considerably slower than in axolotls and newts (95 days post‐amputation for complete regeneration) despite having a significantly smaller genome size than axolotls or newts.

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Response of the adult newt ventricle to injury

Cited by 364 publications

References 18 publications

Mechanisms of urodele limb regeneration

Mechanisms of urodele limb regeneration

BAF60 A, B, and Cs of muscle determination and renewal

Limb regeneration in a direct‐developing terrestrial salamander, Bolitoglossa ramosi (Caudata: Plethodontidae)

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