Response of sweat electrolyte concentrations to 9 alpha-fluorohydrocortisone in patients with cystic fibrosis and their families

Lobeck, Charles C.; McSherry, Nona R.

doi:10.1016/s0022-3476(63)80136-5

Cited by 30 publications

(9 citation statements)

References 6 publications

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“…1 2 This was not seen in older women or in squamous carcinoma of the cervix, which in the United Standardised incidences ofinvasive cervical cancer (numbers ofcaseslmillion) by histological type and time periodfrom threeEnglish regional cancer registrzes States has been decreasing in women at all ages. Peters et al suggested that the increase in the incidence of adenocarcinoma might reflect the use of oral contraceptives by young women.'…”

Section: Short Reportsmentioning

confidence: 98%

Abnormal sweat electrolytes in symptomatic human immunodeficiency virus infection in a child.

Skeoch

Coutts²,

Goel³

et al. 1987

BMJ

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Section: Short Reportsmentioning

confidence: 98%

Abnormal sweat electrolytes in symptomatic human immunodeficiency virus infection in a child.

Skeoch

Coutts²,

Goel³

et al. 1987

BMJ

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“…During the patient's hospital admission, his mother was well instructed on how to collect urine. Saliva and sweat were collected repeatedly according to previously published methods (Lobeck & McSherry, 1963;Anand et al, 1976).…”

Section: Sample Collectionsmentioning

confidence: 99%

Pseudohypoaldosteronism: Decreased Aldosterone Levels With Age Without Significant Change in Urinary Sodium Excretion

Yasuda

Noda-Cho

Nishioka

et al. 1986

Clinical Endocrinology

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To clarify age-related changes in the plasma renin activity (PRA)-aldosterone (ALDO) system in relation to urinary sodium (Na) excretion in pseudohypoaldosteronism type I (PHA), we followed a patient with PHA serially by measuring the hormonal balance and urinary electrolyte excretion for 5 years. The patient was diagnosed as PHA mainly on the basis of extremely high PRA (170 ng/ml/h) and ALDO (1670 ng/dl) despite massive urinary Na excretion, a normal ALDO/PRA ratio (mean value = 11), and the ineffectiveness of 9 alpha-fluorocortisol (Florinef) to reduce urinary Na excretion and PRA-ALDO. The pattern of reduction in PRA-ALDO with age in this patient was almost identical with that of normal infants and children and was most remarkable during the first 18 months of life. During this period, there were statistically significant correlations between age and each of the following values: PRA (r = -0.753, n = 9, P less than 0.05), ALDO (r = -0.736, n = 11, P less than 0.01) and urinary ALDO excretion (r = -0.840, n = 9, P less than 0.01). But the reduction of PRA-ALDO in this patient was not the result of increased urinary Na excretion with age. Although PRA and ALDO values in this patient did decrease with age, they were still high compared with age-matched controls, suggesting a marginal state of Na balance. Thus, we conclude that PRA-ALDO levels in PHA decrease with age in the same pattern as in normal infants and children without a significant change in urinary Na excretion, possibly through increased renal conservation of Na, the mechanism of which should be clarified in a future study.

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“…Blood pressure was normal throughout the study period. Creatinine clearance during this admission was 139 ml/min/1.73 rn2, Red blood cell sodium concentration was 18 mEq/liter cells (normal, [16][17][18][19][20][21][22][23][24][25] and potassium concentration 1 12 mEq/liter cells (normal. 82-108).…”

Section: Study Period 3: Effects Of Gradual Reduction Of Sodium Intakmentioning

confidence: 99%

Pseudohypoaldosteronism due to Sweat Gland Dysfunction

et al. 1976

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Response of sweat electrolyte concentrations to 9 alpha-fluorohydrocortisone in patients with cystic fibrosis and their families

Cited by 30 publications

References 6 publications

Abnormal sweat electrolytes in symptomatic human immunodeficiency virus infection in a child.

Abnormal sweat electrolytes in symptomatic human immunodeficiency virus infection in a child.

Pseudohypoaldosteronism: Decreased Aldosterone Levels With Age Without Significant Change in Urinary Sodium Excretion

Pseudohypoaldosteronism due to Sweat Gland Dysfunction

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