Response of Squamous Cell Carcinoma of the Nose of the Cat to Treatment With X Rays

Abstract

Results of radiotherapy of 88 cats with squamous cell carcinomas of the nose were recorded. Two treatment regimens were used: 2000 rad per treatment at monthly intervals and 1000 rad at two‐day intervals, with a total dose of 3000 rad. Results indicated that three treatments of 1000 rad each was superior to monthly treatments of 2000 rad. Small lesions had the highest cure rate. Response of large lesions to radiotherapy was poor.

Ki67 Reactivity in Nasal and Periocular Squamous Cell Carcinomas in Cats Treated with Electron Beam Radiation Therapy

“…4,7,8 The DFI with a median of 414 days was comparable to that in the studies of Carlisle and Gould with a DFI of 13 months (390 days), Fidel with a DFI of 16.5 months (502 days). In our study, no control population was treated with a conventional radiation regimen, which makes statements about efficacy difficult.…”

“…These numbers are comparable to, or only slightly below, those of previous studies. 4,7,8 In 3 cats, the question arises if tumor recurrence was true recurrence or new growth of tumor because they occurred long after initial radiation therapy (DFI 5 414, 977, and 1,450 days, respectively) and showed a slow growth pattern.…”

“…In contrast to surgery, radiation therapy was found to be a cosmetically appealing and effective option. 4,[6][7][8] Squamous cell carcinomas are thought to be rapidly dividing tumors. A potential tumor doubling time of approximately 5 days was determined by using flow cytometry and bromodeoxyuridine (BrdU) staining.…”

Curettage and diathermy: a treatment for feline nasal planum actinic dysplasia and superficial squamous cell carcinoma

“…Numerous treatments have been described including hyperthermia, external beam radiotherapy, nasal planum resection, cryotherapy, photodynamic therapy, intralesional chemotherapy, combined radiotherapy and intralesional chemotherapy, strontium‐90 plesiotherapy and electrochemotherapy (Grier et al . , Carlisle & Gould , Withrow & Straw , Clarke , Peaston et al . , Theon et al .…”

Photodynamic Therapy of Superficial Nasal Planum Squamous Cell Carcinomas in Cats: 55 Cases

“…SCCs are classified according to the World Health Organization staging system for feline tumors of epidermal origin 2 . Cutaneous tumors, classified as T is , T 1 , or T 2 can be treated by surgery, 3 radiotherapy, 4,5 hyperthermia, 6 chemotherapy, 7 and plesiotherapy 8 …”