Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women

Elosúa, Roberto; Molina, Luís; Fitó, Montserrat; Arquer, Andreu; Sánchez-Quesada, José Luis; Covas, María Isabel; Ordóñez-Llanos, Jordi; Marrugat, Jaume

doi:10.1016/s0021-9150(03)00018-2

Cited by 232 publications

(154 citation statements)

References 30 publications

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“…In turn, the latter were increased as a result of a greater consumption of oxygen by the electronic transport chain during the training. This situation explains the greater GSHPx and CAT activity (Table 3), if it is borne in mind that the increase in O 2 -proceeding from the electron transport chain would be blocked by the SOD producing glutathione peroxidase These data are in agreement with previous studies which reported increases in GSH-Px and CAT after aerobic training periods (Ji, 1999;Elosua et al, 2003). According to Powers et al (1999) increased concentrations of GSH, GSH-Px and CAT reduce the risk of cell injury, improve performance, and delay muscle fatigue.…”

Section: Discussionsupporting

confidence: 91%

“…The increase in GSH (Figure 1), observed in many other studies (Ji et al, 1991;Somani et al, 1995;Elosua et al, 2003) can be explained as an adaptation-compensation response to an increase in ROS production. In turn, the latter were increased as a result of a greater consumption of oxygen by the electronic transport chain during the training.…”

Section: Discussionsupporting

confidence: 52%

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Effects of an aerobic training program on oxidative stress biomarkers in bulls

Escribano¹,

Túnez²,

Requena³

et al. 2010

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to evaluate the effect of aerobic training (16 weeks -T1 and 24 weeks -T2) on oxidative stress biomarkers. To this end, GSH, GSH-peroxidase (GSH-Px) and catalase (CAT) activity were analysed in plasma. Nine bulls (3-4 years), were included in this work. The exercise training protocol was performed in a track ("taurodromo") three days per week for 24 weeks and consisted of 400 m warming up, 1200 m to 4-5 m/s, two minutes' resting, 1200 m to 4-5 m/s and, finally, 400 m walking. The results reflected that GSH-Px activity was higher at T1 (6.18 ± 0.45) than at baseline (T0; 2.31 ± 0.08) while the GSH level (2.98 ± 0.37) was lower vs. T0 (14.59 ± 3.40). Moreover, there were significant increases in GSH-Px (18.23 ± 1.36) and CAT (2.52 ± 0.04) activities and the recovery of basal values in GSH (11.75 ± 2.84) in T2. In conclusion, the type of training carried out in this study involved two well-defined stages: (i) a period of perturbation, followed by (ii) adaptation. The former stage was characterised by the induction of oxidative stress manifested as a decrease in the GSH, and the latter (T2) by the recovery of this non-enzymatic antioxidant.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 52%

Effects of an aerobic training program on oxidative stress biomarkers in bulls

Escribano¹,

Túnez²,

Requena³

et al. 2010

Vet. Med. - Czech

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“…8,9 However, with respect to antioxidant supplementation and exercise-induced oxidative stress and tissue injury, a clear consensus in no way exists. Disparities in the literature regarding antioxidant supplementation and attenuation of oxidative damage are likely due to several factors including training status of the subject population, 10 dietary intake, 11 as well as the magnitude and duration of supplementation period. It should be noted, that no antioxidant treatment completely eliminated oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant effect of diphenyl diselenide on oxidative stress caused by acute physical exercise in skeletal muscle and lungs of mice

Prigol

Luchese

Nogueira

2009

Cell Biochemistry & Function

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This study was designed to examine if diphenyl diselenide (PhSe) 2 , an organoselenium compound, attenuates oxidative stress caused by acute physical exercise in skeletal muscle and lungs of mice. Swiss mice were pre-treated with (PhSe) 2 (5 mg kg -1 day -1 ) for 7 days. At the 7th day, the animals were submitted to acute physical exercise which consisted of continuous swimming for 20 min. The animals were euthanized 1 and 24 h after the exercise test. The levels of thiobarbituric acid reactive species (TBARS), non-protein thiols (NPSH) and ascorbic acid and the activity of catalase (CAT) were measured in the lungs and skeletal muscle of mice. Glycogen content was determined in the skeletal muscle of mice. Parameters in plasma (urea and creatinine) were determined. The results demonstrated an increase in TBARS levels induced by acute physical exercise in the skeletal muscle and lungs of mice. Animals submitted to exercise showed an increase in non-enzymatic antioxidant defenses (NPSH and ascorbic acid) in the skeletal muscle. In lungs of mice, activity of CAT was increased. (PhSe) 2 protected against the increase in TBARS levels and ameliorated antioxidant defenses in the skeletal muscle and lungs of mice submitted to physical exercise. These results indicate that acute physical exercise caused a tissue-specific oxidative stress in the skeletal muscle and lungs of mice. (PhSe) 2 protected against oxidative damage induced by acute physical exercise in mice.

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“…GPX reduces hydrogen and lipid peroxides to less toxic hydroxy fatty acids using glutathione as a reducing agent, and these compounds play a major role in defending the body against reactive oxygen species(2). Several exercise training studies have found that GPX activity increases in response to training, and that GPX declines in response to detraining (3)(4)(5)(6)(7). However, because most populationbased physical activity interventions aim to increase levels of activities in the low to moderate exertion range, such as promoting walking, it is important to understand associations between biomarkers and variation in activity for levels of activity that are lower than those used in exercise training trials (8).…”

Section: Introductionmentioning

confidence: 99%