Response of osteoblasts and preosteoblasts to calcium deficient and Si substituted hydroxyapatites treated at different temperatures

Matesanz, María Concepción; Linares, Javier; Oñaderra, Mercedes; Feito, María José; Martínez‐Vázquez, Francisco J.; Sánchez‐Salcedo, Sandra; Arcos, Daniel; Portolés, María Teresa; Vallet‐Regí, María

doi:10.1016/j.colsurfb.2015.06.014

Cited by 22 publications

(14 citation statements)

References 47 publications

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“…Thus, the higher proliferation of the PLA‐HA composites indicates that presence of HA in the composites was able to enhance the interaction between osteoblast cells and the PLA‐HA composites as reported in similar research . In essence, the presence of HA in PLA‐HA composites as prepared in this study can promote cell attachment and growth, thereby ensuring good biological performance of the PLA‐HA composites …”

Section: Resultssupporting

confidence: 70%

Synergized poly(lactic acid)–hydroxyapatite composites: Biocompatibility study

Akindoyo

Beg

Ghazali

et al. 2018

J of Applied Polymer Sci

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In vitro biocompatibility of impact modified composites produced from poly(lactic acid) (PLA) and hydroxyapatite (HA) is reported in this study. Surface modification was previously used to facilitate the dispersion of HA in PLA, whereas impact property of the PLA-HA composites was deliberately enhanced as it was necessary. Herein, osteoblast cell culture assay was used to assess the possible effects of HA surface modification and impact modification on the cell behavior in physiological media. Furthermore, antimicrobial properties of the HA were assessed. Evidence of HA modification was confirmed through elemental and spectroscopic analysis. Incorporation of HA offered better cell attachment and proliferation to the PLA matrix, with significant increase in the cell viability (%). Also, modification of HA did not present obvious cytotoxicity to the PLA-HA composite. Conversely, incorporation of impact modifier slowed down the rate of cell proliferation on the composite surface but facilitates increased wettability.

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Section: Resultssupporting

confidence: 70%

Synergized poly(lactic acid)–hydroxyapatite composites: Biocompatibility study

Akindoyo

Beg

Ghazali

et al. 2018

J of Applied Polymer Sci

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“…158 Although the amount of Si that can be incorporated into HAp ranges between 0.1 and 0.5 wt%, [159][160][161][162] Si-HAps have evidenced higher bioactive behavior compared to nonsubstituted apatites. [163][164][165][166][167] Si-HAp coatings have been prepared by magnetron sputtering. 168 Since the Si substitution is very limited, HAp and Si were sputtered from different targets instead of a single Si-HAp one, yielding a layer of Si-HAp of 0.7 mm in thickness and with a Si content of approximately 0.8 wt%.…”

Section: Anionic Substitutions In Hydroxyapatite Coatingsmentioning

confidence: 99%

Substituted hydroxyapatite coatings of bone implants

2020

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“…Matesanz et al . demonstrated that the osteoblasts-like cells and preosteoblasts-like cells could adhere to and proliferate on the Se-HA based scaffold, which leads to enhance osteogenesis ability compared to HA-based nanocomposites 25 .…”

Section: Introductionmentioning

confidence: 98%

Nanostructured selenium-doped biphasic calcium phosphate with in situ incorporation of silver for antibacterial applications

Nie

Hou

Wang

et al. 2020

Sci Rep

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Selenium-doped nanostructure has been considered as an attractive approach to enhance the antibacterial activity of calcium phosphate (cap) materials in diverse medical applications. in this study, the selenium-doped biphasic calcium phosphate nanoparticles (SeB-NPs) were first synthesized. Then, silver was in situ incorporated into SeB-NPs to obtain nanostructured composite nanoparticles (Ag SeB-NPs). Both SeB-NPs and Ag SeB-NPs were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-Vis), X-ray photoelectron spectroscopy (XPS), and Raman spectra. The results confirmed that the SeO 3 2− was doped at the po 4 3− position and silver nanoparticles were deposited on the surface of SeB-NPs. Next, Transmission Electron Microscopy (TEM) analysis displayed that the prepared Ag SeB-NPs had a needlecluster-like morphology. CCK-8 analysis revealed SeB-NPs and Ag SeB-NPs had good cytocompatibility with osteoblasts. the antibacterial activity of the prepared Ag SeB-NPs was confirmed by using Gramnegative E. coli and Gram-positive S. aureus. The above results manifested the significance of the final Ag SeB-NPs for biomedical applications. Tissue engineering has been widely used in bone graft and dentistry due to a large number of patients require grafting resulting from congenital conditions, trauma, and tumor resection, and so on 1-3. Mineralized tissues, such as bone, tooth enamel, dentin, and cementum, are enriched with significant amounts of ionic substitutions, including sodium, potassium, and carbonate groups. These elements can affect the functionality of related tissues 4,5. Calcium phosphate (CaP) based nanoparticles, including hydroxyapatite (Ca 10 (PO 4) 6 (OH) 2 , HA), β-tricalcium phosphate (Ca 3 (PO 4) 2 , β-TCP), tetracalcium phosphate (Ca 4 (PO 4) 2 O; TTCP), biphasic calcium phosphate (BCP), and so forth, were well-known in implant surgery because of their excellent biocompatibility, biodegradability, and tunable physicochemical properties. Compared to HA or β-TCP, biphasic calcium phosphate (BCP) composed of HA and β-TCP, performed better mechanical properties, higher biological activity, and adjustable degradation rate 6-10. Bacteria attached to the implanted medical devices or scaffold can cause healthcare-associated infections, such as the formation of biofilm, which further results in local inflammation and infection. Therefore, the scaffold with excellent antibacterial properties provides an overwhelming advantage in the clinic stage 11,12. Many metal nanoparticles, such as silver (Ag), zinc oxide (ZnO), and titanium dioxide (TiO 2), performed strong antibacterial properties and low toxicity towards mammalian cells, some of these nanoparticles have been widely applied in a range of areas 13-20. Silver (Ag) is stable in the body fluids and can be used in antibacterial implants due to silver can easily binds to bacterial DNA and RNA, resulting in bacteria death 21. However, the antibacterial effect of nanoparticles was influenced...

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Response of osteoblasts and preosteoblasts to calcium deficient and Si substituted hydroxyapatites treated at different temperatures

Cited by 22 publications

References 47 publications

Synergized poly(lactic acid)–hydroxyapatite composites: Biocompatibility study

Synergized poly(lactic acid)–hydroxyapatite composites: Biocompatibility study

Substituted hydroxyapatite coatings of bone implants

Nanostructured selenium-doped biphasic calcium phosphate with in situ incorporation of silver for antibacterial applications

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