Response of mitochondrial enzymes to decreased muscular activity

Rifenberick, DH; Jg, Gamble; Max, SR

doi:10.1152/ajplegacy.1973.225.6.1295

Cited by 73 publications

(25 citation statements)

References 1 publication

(1 reference statement)

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“…MnS00 and fumarase) decreased to a greater extent than the membrane bound enzyme, cytochrome c oxidase. This data is consistent with the observation of Rifenberick et al (1973) who observed a greater decrease in a matrix enzyme (malate dehydrogenase) than in membrane bound enzymes (cytrochrome c oxidase and monoamine oxidase) in mitochondria isolated from atrophic muscle.…”

Section: )supporting

confidence: 93%

“…Den p rvation or disuse of muscle results in a loss of various mitochondrial functions (Joffe et al" 1981;1933) as well as decrease in several mitochondrial enzyme activities (Turner and Manchester, 1972;Booth and Kelso, 1972;Rifenberick et al, 1973;Nemeth et al, 1980). Conversely, endurance training induces a biochemical adaptation of muscle mitochondria, leading to an increase in oxidative capacity and specific activity of serveral mitochondrial enzymes ; Davies et al, 1981).…”

Section: )mentioning

confidence: 99%

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Differential Effect of Denervation on Free‐Radical Scavenging Enzymes in Slow and Fast Muscle of Rat

Asayama

Dettbarn

Burr

1986

Journal of Neurochemistry

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: To determine the effect of denervation on the free‐radical scavenging systems in relation to the mitochondrial oxidative metabolism in the slow‐twitch soleus and fast‐twitch extensor digitomm longus (EDL) muscles, the sciatic nerve of the rat was crushed in the mid‐thigh region and the muscle tissue levels of five enzymes were studied 2 and 5 weeks following crush. Recently developed radioimmunoassays were utilized for the selective measurement of cuprozinc (cytosolic) and man‐gano (mitochondrial) superoxide dismutases. Total tissue content of cuprozinc superoxide dismutase showed a mild decrease after denervation in slow but not in fast muscle. Manganosuperoxide dismutase and fumarase decreased markedly at 2 weeks and returned toward control levels by 5 weeks, the changes appearing to be greater in slow than in fast muscle. At 2 weeks, cytochrome c oxidase decreased significantly in slow, but not in fast muscle. GSH‐peroxidase at baseline was 10‐fold higher in slow than in fast muscle, markedly decreased at 2 weeks in slow muscle, and returned toward control levels at 5 weeks, whereas the total enzyme activity in fast muscle did not change through 5 weeks. These data represent the first systematic report of free radical scavenging systems in slow and fast muscles in response to denervation. Selective modification of cuprozinc and manganosuper‐oxide dismutases and differential regulation of GSH‐peroxidase was demonstrated in slow and fast muscle.

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Section: )supporting

confidence: 93%

Section: )mentioning

confidence: 99%

Differential Effect of Denervation on Free‐Radical Scavenging Enzymes in Slow and Fast Muscle of Rat

Asayama

Dettbarn

Burr

1986

Journal of Neurochemistry

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“…Critically ill patients lying in the ICU are always bed bound and often sedated, which most likely will influence mitochondrial density. Several human studies have shown that immobilization for 4 -7 wk decreases mitochondrial enzyme activity in various muscle types by ϳ20% (3,15,23,20,28). The ICU patients included in the present study were immobilized for a shorter period of time (medium ICU stay of 7.5 days) and still had more pronounced mitochondrial derangements in skeletal muscle.…”

Section: Discussionmentioning

confidence: 84%

Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure

Fredriksson¹,

Hammarqvist²,

Strigård³

et al. 2006

American Journal of Physiology-Endocrinology and Metabolism

175

149

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Critically ill patients treated for multiple organ failure often develop muscle dysfunction. Here we test the hypothesis that mitochondrial and energy metabolism are deranged in leg and intercostal muscle of critically ill patients with sepsis-induced multiple organ failure. Ten critically ill patients suffering from sepsis-induced multiple organ failure and requiring mechanical ventilation were included in the study. A group ( n = 10) of metabolically healthy age- and sex-matched patients undergoing elective surgery were used as controls. Muscle biopsies were obtained from the vastus lateralis (leg) and intercostal muscle. The activities of citrate synthase and mitochondrial respiratory chain complexes I and IV and concentrations of ATP, creatine phosphate, and lactate were analyzed. Morphological evaluation of mitochondria was performed by electron microscopy. Activities of citrate synthase and complex I were 53 and 60% lower, respectively, in intercostal muscle of the patients but not in leg muscle compared with controls. The activity of complex IV was 30% lower in leg muscle but not in intercostal muscle. Concentrations of ATP and creatine phosphate were, respectively, 40 and 34% lower, and lactate concentrations were 43% higher in leg muscle but not in intercostal muscle. We conclude that both leg and intercostal muscle show a twofold decrease in mitochondrial content in intensive care unit patients with multiple organ failure, which is associated with lower concentrations of energy-rich phosphates and an increased anaerobic energy production in leg muscle but not in intercostal muscle.

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“…Moreover, in patients with the chronic fatigue syndrome, who are certainly deconditioned, similar abnormalities could not be demonstrated by 31 P NMR during exercise testing [52]. In addition, lack of exercise decreases hexokinase and increases lactic dehydrogenase [53]. These metabolic changes were not found in rats with CHF [3].…”

Section: Are Skeletal Muscle Abnormalities Reversible?mentioning

confidence: 99%

Peripheral and respiratory muscles in chronic heart failure

Stassijns

Lysens²,

Decramer³

1996

Eur Respir J

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Since the shortness of breath correlates poorly with changes in lung function, changes in the respiratory muscles have been investigated. Studies have demonstrated diaphragmatic myopathy and atrophy similar, in part, to the changes in peripheral skeletal muscles. In CHF, type I (slow twitch) fibre atrophy is seen in respiratory as well as in peripheral muscles.The mechanism of these alterations remains to be elucidated. Studies into the mechanism of muscle dysfunction in congestive heart failure are relevant to the prospect of treatment of the changes in peripheral and respiratory muscles.

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Response of mitochondrial enzymes to decreased muscular activity

Cited by 73 publications

References 1 publication

Differential Effect of Denervation on Free‐Radical Scavenging Enzymes in Slow and Fast Muscle of Rat

Differential Effect of Denervation on Free‐Radical Scavenging Enzymes in Slow and Fast Muscle of Rat

Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure

Peripheral and respiratory muscles in chronic heart failure

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