Response of MG63 Osteoblast-Like Cells on Pyrolytic Carbon Coated Carbon/Carbon Composites

Abstract

In order to improve the biocompatibility of carbon/carbon(C/C) composites used for hip prosthesis, pyrolytic carbon coating was prepared on their surface by chemical vapor deposition. The microstructures of the samples were analyzed by scanning electron microscopy (SEM) and the biomedical response was assessed by the morphology and proliferation of MG63 osteoblast-like cells. The results show that the texture on the surface of C/C composites changes from chaotic structure to uniform state after the pyrolytic carbon coating is prepared. Osteoblasts cultured on pyrolytic carbon coating present flat shape with thin thickness, and display better proliferation in comparison with those on the uncoated C/C composites surface.

Influence of surface roughness of carbon materials on human osteoblast‐like cell growth

“…Finally, for each of the three groups of samples (A, B, and C), there were seven samples. For contact angle and biocompatibility tests, group A was divided into subgroups pure C/C (1,2) and PyC (3)(4)(5)(6)(7). For each combination group/ series, three samples modified on both sides were prepared.…”

“…PyC is usually prepared by pyrolytic decomposition of hydrocarbon vapours, which are deposited on a substrate. This material is reasonably biocompatible …”

“…C/C composites, composed of carbon matrix reinforced by carbon fibres, sometimes also referred to as carbon fibre reinforced composites (CFRC), are promising materials for use in medicine and in biology. [3][4][5][6] Their chemical composition is close to the composition of pure carbon, and it can therefore be expected that the materials will be well tolerated by cells in vitro and by tissues in vivo. Their density is similar to that of bone, but a danger of particle release has sometimes been reported.…”

“…This material is reasonably biocompatible. 5,11,15,16 Ti-C:H is a nomenclature for a layer with a mixture of carbon and titanium atoms, sometimes with a gradual decrease in the titanium concentration to almost pure carbon through the thickness of the layer. This layer has usually been prepared by radio frequency magnetron sputtering.…”

Biotribology Behavior of Ultra-High Molecular Weight Polyethylene against Carbon/Carbon Composites Used for Hip Joint Replacement

“…Carbon/carbon (C/C) composites are introduced to orthopedic implants because they are stable in the physiological environment. Moreover, as a kind of fiber reinforcement material, they show high strength and toughness [6][7][8]. Besides, they have lower elastic modulus than the biomedical metal, which favors the compatibility with the human bone [9].…”