Response of Lactating Dairy Cows to High Levels of Dietary Molybdenum

Huber, J.T.; Price, N. O.; Engel, R. W.

doi:10.2527/jas1971.322364x

Cited by 28 publications

(8 citation statements)

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“…Any accumulation of bound Cu in the liver will not be noticeable due to a concomitant decrease in total live Cu content brought about by Mo supplementation; this decrease may be more rapid than the Cu accumulation. The continuous decrease in hepatic Cu content in cattle at increasing levels of dietary Mo, as reported by Vanderveen & Keener (1964) and Huber et al (1971) may have been due to the lack of Cu in the diet. In the present trial no sign of Cu deficiency was observed in any of the haematological factors tested or in the Cu content of any tissues.…”

Section: Discussionsupporting

confidence: 57%

“…Suttle (1975) pointed out that the extent and risk of the depression of Cu concentration in liver by Mo supplementation depends on the Cu status of the liver, the duration of Mo feeding and the dietary levels of Cu and Mo during this period. However, with Mo intakes of between 20 and lWmg/sheep per d Dick (1954) observed very little change in hepatic Cu content, though in cattle Vanderveen & Keener (1964) and Huber et al (1971) observed decreased levels of hepatic Cu at higher Mo intakes.…”

mentioning

confidence: 97%

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Effect of different levels of dietary molybdenum on copper and Mo metabolism in sheep fed on high levels of Cu

Ryssen

Stielau

1981

Br J Nutr

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1. Distribution of copper and molybdenum was followed in the body tissues of sheep fed on high levels of Cu (82 mg Cu/sheep per d), sulphur (3·77 g S/sheep per d) and different levels of Mo (0·6 20·8, 38.4 and 58.5 mg Mo/sheep per d).2. Liver Cu content decreased as Mo intake increased from 0.6 to 38.4 mg/d, but increased again at high intakes of Mo. With an Mo intake of 58.5 mg/d, the Cu content of liver, kidney, lung, spleen and muscle tissue was significantly higher than with an intake of 20.8 mg Mo/d. The trend of increased Cu concentrations in kidneys and plasma was already evident at an Mo intake of 38.4 mg/sheep per d.3. High positive correlations were observed between Cu and Mo in both the kidney cortex and medulla of the sheep at the two highest Mo treatments.4. At constant S intake, Mo concentrations in the tissues tended to increase in proportion to Mo intakes. No indication of any detrimental effect due to the accumulation of Mo in the tissues was observed.5. It was suggested that in the presence of an abundance of Mo, Cu and S, compounds containing these minerals in metabolically unavailable forms accumulate in the body, first in the kidneys, but eventually also in the other tissues of the sheep.

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Section: Discussionsupporting

confidence: 57%

mentioning

confidence: 97%

Effect of different levels of dietary molybdenum on copper and Mo metabolism in sheep fed on high levels of Cu

Ryssen

Stielau

1981

Br J Nutr

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“…There was an increase over time for milk Mo in all 3 yr (P = 0.0001 for all years). Studies indicate that the Mo content of milk in cattle responds rapidly and directly to Mo intake (Huber et al 1971;Vanderveen and Keener 1964). Therefore, the calves would have received higher concentrations of Mo in the milk as the grazing season progressed.…”

Section: Milkmentioning

confidence: 99%

Copper and health status of cattle grazing high-molybdenum forage from a reclaimed mine tailing site

Gardner¹,

Broersma²,

Popp³

et al. 2003

Can. J. Anim. Sci.

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. 2003. Copper and health status of cattle grazing high-molybdenum forage from a reclaimed mine tailing site. Can. J. Anim. Sci. 83: 479-485. High concentrations (21-44 mg kg -1 dry matter) of Mo have been identified in forage in several reclaimed mining areas in British Columbia. Since Mo concentrations greater than 5 mg kg -1 in forage dry matter may result in molybdenosis because of a secondary Cu deficiency in ruminants, a study was undertaken to determine if cattle can safely graze the reclaimed land. For 12-wk grazing periods in 1994, 1995 and 1996, 32 cow/calf pairs grazed high-Mo forage at a reclaimed mine tailings site located at the Highland Valley Copper mine near Logan lake, BC. Half of the animals in the trial received a Cu supplement (All-Trace copper bolus) and the other half served as a control group. There were no significant differences (P < 0.05) in weight gain, liver Mo, serum Cu and Mo, and milk Cu and Mo between the two treatment groups of cows. Liver Cu was higher for the Cu bolus group at certain time periods in 1994 and 1995, indicating that the bolus was effective at supplying Cu. At all times, the liver Cu levels for the animals remained above the recommended critical level of 25 mg kg -1 dry matter. Animals appeared healthy and no signs of Cu deficiency were observed. . Une concentration de Mo supérieure à 5 mg par kg de matière sèche pouvant entraîner la molybdénose consécutive-ment à une carence secondaire en cuivre (Cu) chez les ruminants, les auteurs ont tenté d'établir si les bovins peuvent paître sans danger sur ces terres. Trente-deux couples vaches/veaux ont brouté dans des champs à forte concentration de Mo pendant 12 semaines en 1994, 1995 et 1996, sur d'anciens sites restaurés à la mine de cuivre Highland Valley, près de Logan Lake, en Colombie-Britannique. La moitié des animaux ont reçu un supplément de Cu (cuivre pour bol alimentaire All-Trace), l'autre moitié servant de témoins. Les auteurs n'ont relevé aucune variation significative (P < 0,05) entre les deux traitements pour le gain de poids et la concentration de Mo dans le foie, de Cu et de Mo dans le sang, et de Cu et de Mo dans le lait. Le groupe qui avait reçu le Cu alimentaire présentait plus de Cu dans le foie à certains moments, en 1994 et 1995, signe que cette technique donne de bons résultats pour compenser le manque de Cu. La concentration de Cu dans le foie des animaux reste toujours au-dessus du seuil critique recommandé de 25 mg par kg de matière sèche. Les animaux semblaient tous en bonne santé et aucun symptôme de carence en cuivre n'a été observé.

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“…The condition is rarely seen during the feeding of stored forages in either beef or dairy cattle. Copper deficiency can be highly detrimental for cattle grazing fresh forage in some regions, but when this same forage is dried as hay, there is no Cu deficiency (Huber et al, 1971; Allaway, 1977). These authors suggested that drying forage makes Cu more available for absorption and reduces the availability of Mo.…”

Section: Molybdenum Toxicitymentioning

confidence: 99%

A Modified Risk Assessment to Establish Molybdenum Standards for Land Application of Biosolids

O’Connor

Brobst²,

Chaney³

et al. 2001

J of Env Quality

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The USEPA standards (40 CFR Part 503) for the use or disposal of sewage sludge (biosolids) derived risk-based numerical values for Mo for the biosolids --> land --> plant --> animal pathway (Pathway 6). Following legal challenge, most Mo numerical standards were withdrawn, pending additional field-generated data using modern biosolids (Mo concentrations <75 mg kg(-1) and a reassessment of this pathway. This paper presents a reevaluation of biosolids Mo data, refinement of the risk assessment algorithms, and a reassessment of Mo-induced hypocuprosis from land application of biosolids. Forage Mo uptake coefficients (UC) are derived from field studies, many of which used modern biosolids applied to numerous soil types, with varying soil pH values, and supporting various crops. Typical cattle diet scenarios are used to calculate a diet-weighted UC value that realistically represents forage Mo exposure to cattle. Recent biosolids use data are employed to estimate the fraction of animal forage (FC) likely to be affected by biosolids applications nationally. Field data are used to estimate long-term Mo leaching and a leaching correction factor (LC) is used to adjust cumulative biosolids application limits. The modified UC and new FC and LC factors are used in a new algorithm to calculate biosolids Mo Pathway 6 risk. The resulting numerical standards for Mo are cumulative limit (RPc)=40 kg Mo ha(-1), and alternate pollutant limit (APL) = 40 mg Mo kg(-1) We regard the modifications to algorithms and parameters and calculations as conservative, and believe that the risk of Mo-induced hypocuprosis from biosolids Mo is small. Providing adequate Cu mineral supplements, standard procedure in proper herd management, would augment the conservatism of the new risk assessment.

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Response of Lactating Dairy Cows to High Levels of Dietary Molybdenum

Cited by 28 publications

References 0 publications

Effect of different levels of dietary molybdenum on copper and Mo metabolism in sheep fed on high levels of Cu

Effect of different levels of dietary molybdenum on copper and Mo metabolism in sheep fed on high levels of Cu

Copper and health status of cattle grazing high-molybdenum forage from a reclaimed mine tailing site

A Modified Risk Assessment to Establish Molybdenum Standards for Land Application of Biosolids

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