Response of Human Dental Pulp Capped with Biodentine and Mineral Trioxide Aggregate

Nowicka, Alicja; Lipski, Mariusz; Parafiniuk, Mirosław; Sporniak‐Tutak, Katarzyna; Lichota, Damian; Kosierkiewicz, Anita; Kaczmarek, Wojciech; Buczkowska-Radlińska, Jadwiga

doi:10.1016/j.joen.2013.01.005

Cited by 391 publications

(371 citation statements)

References 29 publications

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“…The liquid contains calcium chloride, which increases the pH and shortens the binding to a few minutes and improves the mechanical properties of the formulation. The studies of other authors have shown similar effects of MTA when used to cover pulp directly [13]. In both groups, total dentin bridge formation was observed and no pulp inflammation was present, suggesting Biodentine as an alternative to MTA [4,5].…”

Section: Age-related Changes In Endodontiumsupporting

confidence: 61%

Endodontium — together or separately?

Kleinert¹,

Kleinert²,

Ozimirska³

et al. 2018

Folia Morphol

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Section: Age-related Changes In Endodontiumsupporting

confidence: 61%

Endodontium — together or separately?

Kleinert¹,

Kleinert²,

Ozimirska³

et al. 2018

Folia Morphol

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“…To evaluate the response of the dental pulp to each material, we used a modified version of the scoring system devised by Nowicka et al 13) . This scoring system includes evaluation of the calcific barrier, inflammation of the dental pulp, dental pulp congestion, and formation of an odontoblast layer.…”

Section: Discussionmentioning

confidence: 99%

Biological efficacy of two mineral trioxide aggregate (MTA)-based materials in a canine model of pulpotomy

Lee

Kang

Song

et al. 2017

Dental Materials Journal

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The aim of this study was to compare the biocompatibility of Endocem Zr ® and ProRoot MTA ® by histopathologic analysis in a canine model of pulpotomy. This study utilized 39 teeth of two beagle dogs. The exposed pulp tissues were treated by pulpotomy using ProRoot MTA (n=19) or Endocem Zr (n=20). After 8 weeks, the teeth were extracted and processed with hematoxylin-eosin staining for histologic evaluation. Most of the specimens in both groups developed a calcific barrier at the pulp amputation site and formed an odontoblast layer. However, some of the Endocem Zr specimens showed less calcific barrier formation with a greater inflammatory response and less odontoblast layer formation when compared with the ProRoot MTA specimens. ProRoot MTA and Endocem Zr specimens developed a calcific barrier; however, ProRoot MTA was more biocompatible than Endocem Zr.

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“…The following criteria were adopted for histologic evaluation. 11,19,20 1. For the presence and histologic feature of the tertiary dentin, the code 0 was used in the absence of tertiary dentin, the code 1 was used in the presence of atubular dentin, and the code 2 was used in the presence of tubular dentin.…”

Section: Animal Experiments and Histologic Examinationmentioning

confidence: 99%

“…Both materials can induce complete dentin bridge formation without inflammatory pulp response. 11 Statin, a specific inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A reductase, has been widely used as a cholesterollowering drug and is considerably cheaper than MTA. Statin also has anti-inflammatory and anti-oxidant properties.…”

mentioning

confidence: 99%

Controlled release of lovastatin from poly(lactic-<em>co</em>-glycolic acid) nanoparticles for direct pulp capping in rat teeth

Lin¹,

Tu²,

Hsieh³

et al. 2017

IJN

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Statin at appropriate concentrations has been shown to induce odontoblastic differentiation, dentinogenesis, and angiogenesis. However, using a carrier to control statin release might reduce toxicity and enhance its therapeutic effects. The aim of this study was to prepare poly( d , l -lactide- co -glycolide acid) (PLGA) nanoparticles that contain lovastatin for application in direct pulp capping. The PLGA–lovastatin particle size was determined using dynamic light scattering measurements and transmission electron microscopy. In addition, the release of lovastatin was quantified using a UV–Vis spectrophotometer. The cytotoxicity and alkaline phosphatase (ALP) activity of PLGA–lovastatin nanoparticles on human dental pulp cells were investigated. Moreover, a real-time polymerase chain reaction (PCR) assay, Western blot analysis, and an enzyme-linked immunosorbent assay (ELISA) were used to examine the osteogenesis gene and protein expression of dentin sialophosphoprotein (DSPP), dentin matrix acidic phosphoprotein 1 (DMP1), and osteocalcin (OCN). Finally, PLGA–lovastatin nanoparticles and mineral trioxide aggregate (MTA) were compared as direct pulp capping materials in Wistar rat teeth. The results showed that the median diameter of PLGA–lovastatin nanoparticles was 174.8 nm and the cumulative lovastatin release was 92% at the 44th day. PLGA–lovastatin nanoparticles demonstrated considerably a lower cytotoxicity than free lovastatin at 5, 9, and 13 days of culture. For ALP activity, the ALP amount of PLGA–lovastatin (100 μg/mL) was significantly higher than that of the other groups for 9 and 13 days of culture. The real-time PCR assay, Western blot analysis, and ELISA assay showed that PLGA–lovastatin (100 μg/mL) induced the highest mRNA and protein expression of DSPP, DMP1, and OCN in pulp cells. Histological evaluation of the animal studies revealed that MTA was superior to the PLGA–lovastatin in stimulating the formation of tubular dentin in an observation period of 2 weeks. However, in an observation period of 4 weeks, it was evident that the PLGA–lovastatin and MTA were competitive in the formation of tubular reparative dentin and a complete dentinal bridge.

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Response of Human Dental Pulp Capped with Biodentine and Mineral Trioxide Aggregate

Cited by 391 publications

References 29 publications

Endodontium — together or separately?

Endodontium — together or separately?

Biological efficacy of two mineral trioxide aggregate (MTA)-based materials in a canine model of pulpotomy

Controlled release of lovastatin from poly(lactic-<em>co</em>-glycolic acid) nanoparticles for direct pulp capping in rat teeth

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