Response of hepatic function to hepatic copper deposition in rats fed a diet containing copper

Sakata, Naoki; Li, Dan; Sugawara, Chieko; Miyake, Hirotsugu

doi:10.1007/bf02788965

Cited by 14 publications

(2 citation statements)

References 19 publications

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“…The increase in GPT and GOT observed in this study may indicate copper-related injury to the liver. Some researchers studied rats fed a diet containing Cu as CuCl 2 (150–600 mg/kg) for 60 d, showed increased activity for both GOT and GPT in serum ( Papadimitriou and Loumbourdis, 2002 , Sugawara et al., 1995 ). Hwang et al.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary copper on elemental balance, plasma minerals and serum biochemical parameters of growing-furring male mink ( Mustela vison )

Gao

et al. 2015

Animal Nutrition

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The objectives of this study were to study the effects of different levels of dietary copper on copper and zinc balance, plasma minerals and serum biochemical parameters of mink in the growing-furring periods. One hundred and five standard dark male mink were randomly assigned to seven groups with the following dietary treatments: basal diet with no supplemental Cu (Control); basal diet supplemented with either 6, 12, 24, 48, 96, or 192 mg/kg Cu from copper sulfate, respectively. The average daily gain (ADG) linearly (P = 0.0026, P = 0.0006) responded to increasing levels of Cu; maximal growth was seen in the Cu24 group. Feed efficiency tended to improve with the increase of dietary copper level (linear P = 0.0010, quad, P = 0.0011). Fecal copper, urinary copper, retention copper responded in a linear (P < 0.05) fashion with increasing level of Cu. The effect of level of Cu was linear (P < 0.001) for plasma Cu concentration. The serum glutamic-oxalacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) activities were increased linearly (P < 0.05) with dose of Cu, but serum total protein (TP) and albumin (ALB) concentrations decreased linearly (P < 0.05) as dietary copper levels increased. Effect of level of Cu was linear (P < 0.001) for serum ceruloplasmin (CER) concentration or Cu-Zn superoxide dismutase (Cu-Zn SOD) activity. Supplemental dose of Cu linearly decreased serum triglyceride (TG) (P = 0.011) and total cholesterol (TC) (P = 0.007). Our results indicated that the activity of Cu-dependent enzymes was enhanced by increasing dietary Cu concentration and that supplementation of Cu in the diet of mink could alter the plasma lipid profile and copper concentration.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary copper on elemental balance, plasma minerals and serum biochemical parameters of growing-furring male mink ( Mustela vison )

Gao

et al. 2015

Animal Nutrition

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“…The mild nature of the morphologic changes in the liver in rats after 12 months of being fed high Cu diets was unexpected, as a deleterious effect on liver function has been reported in Fisher rats fed diets containing 150 to 600 µg of copper chloride/g of food for 60 days. 33 Additionally, although different rat strains have variable susceptibility to Cu toxicosis, the Fischer 344 strain was reported to be a susceptible strain. 34 It is important to emphasize the vast differences in handling excess Cu between mammalian species.…”

Section: Discussionmentioning

confidence: 99%

Effect of chronic exposure to excess dietary copper and dietary selenium supplementation on liver specimens from rats

Aburto¹,

Cribb²,

Fuentealba³

2001

ajvr

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Combined repeated dose and reproductive/developmental toxicities of copper monochloride in rats

Chung

Baek

Lee

et al. 2008

Environmental Toxicology

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This study investigated the combined repeated dose and reproductive/developmental toxicity of copper monochloride in rats. The test substance was administered once daily by gavage at 0, 1.3, 5, 20, or 80 mg/kg/day. Male rats were dosed for a total of 30 days beginning 14 days before mating. Female rats were dosed from 2 weeks before mating to day 3 of lactation throughout the mating and gestation period. At 80 mg/kg/day, deaths were observed in 3 out of 12 females. There was a dose-dependent increase in the incidence of clinical signs and a reduction in the food consumption. Hematological and serum biochemical investigations revealed a decrease in the red blood cell, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin (MCH), and serum total protein levels and an increase in the white blood cell and platelets in males, and a decrease in the MCH and an increase in the platelets in females. Histopathological examination showed an increased incidence of squamous cell hyperplasia of the stomach in both genders as well as increased hematopoiesis of the femur in males. There was an increase in the number of icteric and runt pups at birth. At 20 mg/kg/day, there was an increase in the incidence of clinical signs and squamous cell hyperplasia of the stomach in both genders. At 5 mg/kg/day, an increase in the incidence of squamous cell hyperplasia of the stomach was observed in females. There were no adverse effects in the lowest group in both genders. Based on these findings, the no-observed-adverse-effect levels of copper monochloride were concluded to be 5 mg/kg/day in male rats and 1.3 mg/kg/day in female rats for general toxicity and 20 mg/kg/day for reproductive/developmental toxicity.

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Response of hepatic function to hepatic copper deposition in rats fed a diet containing copper

Cited by 14 publications

References 19 publications

Effects of dietary copper on elemental balance, plasma minerals and serum biochemical parameters of growing-furring male mink ( Mustela vison )

Effects of dietary copper on elemental balance, plasma minerals and serum biochemical parameters of growing-furring male mink ( Mustela vison )

Effect of chronic exposure to excess dietary copper and dietary selenium supplementation on liver specimens from rats

Combined repeated dose and reproductive/developmental toxicities of copper monochloride in rats

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