Response of epidermoid and non-epidermoid cancers of the head and neck to fast neutron irradiation: The Fermilab experience

Kurup, Parvathy D.; Mansell, Joanne; Haken, Randall K. Ten; Hendrickson, Frank R.; Cohen, Lionel; Awschalom, M.; Rosenberg, Ivan

doi:10.1016/0360-3016(84)90026-9

Cited by 11 publications

(1 citation statement)

References 30 publications

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“…Moreover, there is no evidence that radiation therapy hinders recovery of function in those patients who have nerve grafts. Preliminary reports suggest that neutron beam irradiation may be more effective than photons or electrons in the treatment of salivary gland carcinoma [17,18].…”

Section: Treatmentmentioning

confidence: 99%

Diagnosis and pitfalls in the treatment of parotid tumors

Spiro¹

1991

Seminars in Surgical Oncology

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Any swelling near the ear is best considered a parotid neoplasm until proved otherwise. The diagnosis is primarily based on the clinical examination. Imaging studies are best reserved for patients who present with palate or tonsil swellings, which must be distinguished from parapharyngeal or minor salivary gland tumors. Almost all benign, and most malignant parotid tumors can be resected with preservation of the facial nerve. Aspiration biopsy can add useful information, but is not essential for treatment planning as the extent of the surgical procedure is primarily determined by the extent of the tumor. Survival rates in patients with malignant tumors are most significantly influenced by tumor stage. Results seem to have improved in recent years, possibly because we are treating a larger proportion with favorable lesions. Another factor may relate to the enhancement of locoregional control now achieved with postoperative radiotherapy, particularly in patients with Stage III or IV tumors.

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Section: Treatmentmentioning

confidence: 99%

Diagnosis and pitfalls in the treatment of parotid tumors

Spiro¹

1991

Seminars in Surgical Oncology

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Neutron Therapy for Nonresectable Radioresistant Tumors

Cohen

Hendrickson²

1989

Arch Surg

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Effects of arachidonic acid metabolites in a murine model of squamous cell carcinoma

et al. 2000

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Background A murine model (C3H mice) of squamous cell carcinoma (SCCVII) has been used to investigate the role of arachidonic acid (AA) metabolites in head and neck cancer. Inhibition of tumor growth by cyclooxygenase (COX) and lipoxygenase (LOX) inhibitors of AA metabolism has been associated with changes in levels of AA metabolites in tumor tissues and inflammatory cell infiltrates. To characterize this model further, the effects of exogenous AA metabolites on tumor growth in vitro and in vivo were investigated. Methods Following subcutaneous inoculation with SCCVII tumor cells, control (16 mice) and treatment (24 mice) groups were injected with peritumoral vehicle or AA metabolite. Peritumoral injections of prostaglandin E2 (PGE2), leukotriene B4 (LTB4), and 12‐hydroxyeicosatetraenoic acid (12‐HETE) were performed for 16–21 days, and final excised tumor weights were measured. In vitro production of PGE2 and LTB4 was assayed in 2–5 day cultures of SCCVII. Exogenous PGE2 effects on tumor cell growth was assessed with the MTT assay in vitro. Results Tumor growth was significantly inhibited (p = .03) following peritumoral injection of PGE2. Final tumor weights were not affected by LTB4 or 12‐HETE. Tumor inhibition by PGE2 was associated with increased tumor tissue levels of LTB4 (p = .04). In vitro, SCCVII produced minimal amounts of PGE2 and LTB4, and PGE2 had minimal effect on growth. Conclusions In this model, tumor inhibition by exogenous PGE2 is primarily mediated by affecting host‐tumor interactions, although there may be some direct effect on tumor cells. Changes in tumor tissue levels of LTB4 following peritumoral PGE2 administration may be attributable to negative feedback inhibition of the COX pathway with shunting into the LOX pathway. SCCVII cells are probably not a significant source of prostaglandins and leukotrienes in vivo. These data provide insight into the mechanism of action of inhibitors of AA metabolism on tumor growth. © 2000 John Wiley & Sons, Inc. Head Neck 22: 149–155, 2000.

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Response of epidermoid and non-epidermoid cancers of the head and neck to fast neutron irradiation: The Fermilab experience

Cited by 11 publications

References 30 publications

Diagnosis and pitfalls in the treatment of parotid tumors

Diagnosis and pitfalls in the treatment of parotid tumors

Neutron Therapy for Nonresectable Radioresistant Tumors

Effects of arachidonic acid metabolites in a murine model of squamous cell carcinoma

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