Response of deep tufted angioma to interferon alfa

Benign Cutaneous Vascular Tumors of Infancy

“…Like KHE, smaller lesions may be amenable to surgery and treatment of larger lesions with systemic corticosteroids and/or interferon alfa has shown mixed results. 59,65,102 Inconsistent results have been achieved with laser therapy (argon tunable-dye and pulsed-dye). 60 Similar to KHE, successful therapy of TAassociated KMS has been reported using vincristine.…”

“…57,67 The typical TA growth phase consists of slow, lateral extension, which continues for a few months to several years. 59 In contrast with the common hemangioma, spontaneous regression is uncommon. 59,64,68 However, a rare, clinical variant of TA has been described, characterized by very early presentation (congenital or within the first month of life), preferential localization to the lower limbs, and progression toward sclerosis.…”

“…59,64,68 However, a rare, clinical variant of TA has been described, characterized by very early presentation (congenital or within the first month of life), preferential localization to the lower limbs, and progression toward sclerosis. 59,69 Comparative clinical features of the common hemangioma, KHE, and TA are listed in Table 3.…”

“…One third of TAs are tender to palpation. 57,[59][60][61][62][63][64][65][66] Increased vellus hair growth and hyperhidrosis of the surrounding skin have also been described. 61,62,64 On low microscopic power, numerous lobules or "tufts" of capillaries are present within the middle to lower dermis.…”

Congenital Leukemia Cutis Presenting as Multiple Violaceous Lesions in a Newborn

“…The diagnosis is obtained by biopsy, and surgical excision is the treatment of choice. 14,15 Congenital and infantile cutaneous plaques or nodules can often be misdiagnosed. If history, physical examination, and radiologic imaging create any suspicion of malignancy, then a biopsy must be performed for a final histologic diagnosis.…”