Response of Chickens with Different Hemoglobin Genotypes to Phenylhydrazine-induced Anemia

Stino, F. K. R.; Washburn, K. W.

doi:10.3382/ps.0490114

Cited by 13 publications

(11 citation statements)

References 5 publications

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“…1 Decreases in the value of red blood cell parameters were observed in young chickens following feeding or injection of phenylhydrazine (Stino and Washburn, 1970a,b), a powerful haemolytic agent which when given to chickens, produced chronic anaemic stress (Stino and Washburn, 1970b). The comparisons between this experimentally-induced anaemia and the condition produced in the present study in respect to the red cell parameters were similar with common reductions in Hb, PCV, RBCs and MCHC.…”

Section: Discussionsupporting

confidence: 57%

“…The MCV values in this study were significantly reduced at 9 weeks but by the end of the experiment they had recovered to show values similar to the control birds. This recovery may have been due to an increase in bone marrow activity resulting in an increase in MCV (Stino and Washburn, 1970b) and some hyperplasia was seen in the present study.…”

Section: Discussionsupporting

confidence: 47%

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Haematological changes associated with food‐related oral lesions in brown leghorn hens

et al. 1989

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Section: Discussionsupporting

confidence: 57%

Section: Discussionsupporting

confidence: 47%

Haematological changes associated with food‐related oral lesions in brown leghorn hens

et al. 1989

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“…Increased PCV could be accounted for by a stimulation of erythropoietic activity as a result of the influence of dietary aflatoxin on the hematopoietic system. In a previous study (Stino and Washburn, 1970) in which a single dose of the hemolytic agent phenylhydrazine was injected, a similar overcompensation of the erythropoiesis was observed to occur.…”

Section: Resultsmentioning

confidence: 64%

“…Since the MCHC of aflatoxin treated birds was not found to be significantly different from control values, significant dose related depressions of MCV are not supportive evidence for hemolytic anemia. Both chronic and acute hemolytic anemia, when induced by phenylhydrazine in broilers, resulted in increased MCV and decreased MCHC (Stino and Washburn, 1970).…”

Section: Resultsmentioning

confidence: 98%

Variation with Age in Response of Broilers to Aflatoxin

1980

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This study investigated the effects on growth and composition of the blood of dietary aflatoxin fed at levels of 0, 2.5, or 5.0 microgram/g of diet for a three week period beginning at 1, 7, 14, and 21 days of age in commercial broilers. Packed cell volume (PCV), erythrocyte counts, mean corpuscular volume, hemoglobin content and mean corpuscular hemoglobin concentration, body weight, and mortality were measured weekly. Plasma cholesterol and total plasma protein levels were determined weekly. Dietary aflatoxin at levels of 2.5 and 5.0 microgram of aflatoxin per gram of diet when fed to young chicks for three weeks, beginning at either one or seven days, depressed body weight and PCV in a dose related fashion. Body weight and PCV continued to be depressed by the 5.0 microgram/g diets in chicks treated from 2 to 5 weeks of age but not at the lower dosages. The feeding of aflatoxin at levels of up to 5.0 microgram aflatoxin per gram of diet from 3 to 6 weeks of age did not significantly depress body weight or PCV from control levels. Plasma cholesterol and total protein were found to be more sensitive to aflatoxin treatment at the later ages than body weight and other blood values. Plasma cholesterol was significantly depressed by the 5.0 microgram/g level of aflatoxin in all treatment periods, but the 2.5 mirogram/g level of aflatoxin did not significantly reduce cholesterol during the 3 to 6 week treatment period. Plasma proteins were found to be the most sensitive criteria for detecting broiler susceptibility to aflatoxin, being depressed by all levels of aflatoxin for all age groups.

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“…An aberrant type of hemoglobin was produced experimentally by feeding phenylhydrazine to chickens (Stino and Washburn, 1970).…”

Section: Hemoglobinmentioning

confidence: 99%

Blood: Physical Characteristics, Formed Elements, Hemoglobin, and Coagulation

Sturkie¹,

Griminger²

1976

Avian Physiology

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Response of Chickens with Different Hemoglobin Genotypes to Phenylhydrazine-induced Anemia

Cited by 13 publications

References 5 publications

Haematological changes associated with food‐related oral lesions in brown leghorn hens

Haematological changes associated with food‐related oral lesions in brown leghorn hens

Variation with Age in Response of Broilers to Aflatoxin

Blood: Physical Characteristics, Formed Elements, Hemoglobin, and Coagulation

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