Response of Channa striatus Extract Against Monosodium Iodoacetate Induced Osteoarthritis in Rats

Al-Saffar, F. J.; Ganabadi, S.; Fakuraz, S.

doi:10.3923/javaa.2011.460.469

Cited by 9 publications

(13 citation statements)

References 23 publications

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“…No difference was found in terms of the PGE 2 and COX-2 serums between all treatment groups. The findings of serum PGE 2 in our study contradict the findings by Al Saffar et al , who noted that the rats administered with oral Channa had levels of PGE 2 that were reduced significantly, comparable to the group treated with celecoxib (COX-2 inhibitor) [12]. Discrepancies between the results of our study and those of Al Saffar et al [12] may be explained by a few factors.…”

Section: Discussioncontrasting

confidence: 99%

“…The findings of serum PGE 2 in our study contradict the findings by Al Saffar et al , who noted that the rats administered with oral Channa had levels of PGE 2 that were reduced significantly, comparable to the group treated with celecoxib (COX-2 inhibitor) [12]. Discrepancies between the results of our study and those of Al Saffar et al [12] may be explained by a few factors. These include the differences in the OA model used, the biological variations due to the different species of animal, and the dose used in Al Saffar et al 's study [12], which was 40 times more compared to our study.…”

Section: Discussioncontrasting

confidence: 99%

“…Discrepancies between the results of our study and those of Al Saffar et al [12] may be explained by a few factors. These include the differences in the OA model used, the biological variations due to the different species of animal, and the dose used in Al Saffar et al 's study [12], which was 40 times more compared to our study.…”

Section: Discussioncontrasting

confidence: 99%

“…We postulate that Channa improves the anabolic activity in the extracellular matrix component through its action of increasing the synthesis of glycosaminoglycan (GAG) and hyaluronic acid [9]. The improvement of the matrix component in OA by the Channa extract has also been shown by the improvement of the Safranin O fast green staining in terms of the histological assessment of the articular cartilages in an animal study [12]. The incremental increase in GAG will increase the proteoglycans aggregates and strengthen the articular cartilage [4].…”

Section: Discussionmentioning

confidence: 99%

“…In vivo studies using a rabbit OA model showed that there was a reduction of the soft tissue swelling of the joint and it also reduced the density of the protein gene product (PGP) 9.5-immunoreactive nerve fibres in the synovial membrane of the Channa-treated group compared with the control [11]. In another animal study using rats induced with OA, the levels of serum prostaglandin E 2 (PGE 2 ) were significantly reduced in the Channa-treated animals compared to the rats treated with celecoxib (a group of COX-2 inhibitors) [12].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Chondroprotective Activity of Channa striatus in Rabbit Osteoarthritis Model

Kadir

Hamid

Jais

et al. 2019

BioMed Research International

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Objectives. The objective of the study is to evaluate the chondroprotective activity of Channa striatus (Channa) and glucosamine sulphate (glucosamine) on histomorphometric examinations, serum biomarker, and inflammatory mediators in experimental osteoarthritis (OA) rabbit model. Design. Anterior cruciate ligament transection (ACLT) was performed to induce OA in thirty-three male New Zealand white rabbits and were randomly divided into three groups: Channa, glucosamine, and control group. The control group received drinking water and the Channa and glucosamine groups were orally administered with 51.4 mg/kg of Channa extract and 77.5 mg/kg of glucosamine sulphate in drinking water, respectively, for eight weeks and then sacrificed. The articular cartilage was evaluated macroscopically and histologically using semiquantitative and quantitative methods. Serum cartilage oligomeric matric protein (COMP), cyclooxygenase 2 (COX-2) enzyme, and prostaglandin E2 (PGE2) were also determined. Results. Macroscopic analysis revealed that Channa group have a significantly lower severity grade of total macroscopic score compared to the control (p < 0.001) and glucosamine (p < 0.05) groups. Semiquantitative histology scoring showed that both Channa and glucosamine groups had lower severity grading of total histology score compared to the control group (p < 0.001). In comparison with the control, Channa group had lower histopathological changes in three compartments of the joint compared to glucosamine group which had lower histological scoring in two compartments only. The cartilage thickness, area, and roughness of both Channa (p < 0.05) and glucosamine (p < 0.05) groups were superior compared to the control group. However, the Channa group demonstrated significantly less cartilage roughness compared to the glucosamine group (p < 0.05). Serum COMP levels were lower in both Channa (p < 0.05) and glucosamine (p < 0.05) groups compared to the control group. Conclusion. Both oral administration of Channa extract and glucosamine exhibited chondroprotective action on an ACLT OA-induced rabbit model. However, Channa was superior to glucosamine in maintaining the structure of the cartilage.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Chondroprotective Activity of Channa striatus in Rabbit Osteoarthritis Model

Kadir

Hamid

Jais

et al. 2019

BioMed Research International

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Localized delivery of curcumin from injectable gelatin/Thai silk fibroin microspheres for anti-inflammatory treatment of osteoarthritis in a rat model

et al. 2017

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The previously developed gelatin/silk fibroin microspheres were loaded with curcumin and applied for anti-inflammatory treatment in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in a rat model. The MIA-induced OA rats received a single intra-articular injection with gelatin or gelatin/silk fibroin (30/70) microspheres encapsulating curcumin. The therapeutic effects of treatment groups [concentration of interleukin-6 (IL-6) in blood serum, radiographic and the histological grading on articular joint] were compared with those of normal saline treated OA and normal rats. The result showed that both microsphere groups reduced the level of IL-6 in serum after 1 week of treatment. The gelatin/silk fibroin (30/70) microspheres encapsulating curcumin delayed the cellular destruction in articular joint and synovial tissue after 8 weeks. The radiographic and histological gradings on articular cartilage lesion and synovial tissue change of rats treated with gelatin/silk fibroin (30/70) microspheres encapsulating curcumin were close to those of the normal rats. It was explained that the slow-degrading gelatin/silk fibroin (30/70) microspheres released curcumin for extended period and showed a prolonged anti-inflammatory effect, compared to the fast-degrading gelatin microspheres. This delivery system of curcumin was suggested to be applied for localized treatment of anti-inflammatory in OA with minimal invasion.

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A randomized, double-blind study comparing multiple doses of Channa striatus supplementation for knee osteoarthritis

Kadir

Arifah

Jais

et al. 2017

Orient Pharm Exp Med

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Response of Channa striatus Extract Against Monosodium Iodoacetate Induced Osteoarthritis in Rats

Cited by 9 publications

References 23 publications

Evaluation of Chondroprotective Activity of Channa striatus in Rabbit Osteoarthritis Model

Evaluation of Chondroprotective Activity of Channa striatus in Rabbit Osteoarthritis Model

Localized delivery of curcumin from injectable gelatin/Thai silk fibroin microspheres for anti-inflammatory treatment of osteoarthritis in a rat model

A randomized, double-blind study comparing multiple doses of Channa striatus supplementation for knee osteoarthritis

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