Response of capacity and resistance vessels of dog's limb to sympathetic nerve stimulation

Browse, N. L.; Lorenz, R; Shepherd, JT

doi:10.1152/ajplegacy.1966.210.1.95

Cited by 39 publications

(17 citation statements)

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“…Edis, Donald & Shepherd (1970) reported a reduction in heart rate following inflation of balloons in the pulmonary vein-atrial junction, particularly when the initial heart rate was high. In the present experiments we observed that an increase in impulse activity occurred in cardiac sympathetic fibres even when the Cloninger & Green (1955), Browse, Lorenz & Shepherd (1966) and Donald & Ferguson (1970). On the other hand, the results of Edis et al (1970), who observed a decrease in systemic vascular resistance following distension of the pulmonary veinatrial junctions with large balloons, are clearly different from the present results.…”

Section: Discussioncontrasting

confidence: 99%

The effects of stimulation of the left atrial receptors on sympathetic efferent nerve activity

Karim¹,

Kidd²,

Malpus³

et al. 1972

The Journal of Physiology

215

126

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SUMMARY1. Activation of left atrial receptors by distension of balloons at the pulmonary vein-atrial junctions caused an increase in the cardiac sympathetic nerve activity, a decrease in the renal sympathetic nerve activity, and no change in the lumbar and splenic sympathetic nerve activity.2. The cardiac and renal nerve responses to balloon distension were abolished by vagal blockade in the neck.3. The results provide additional evidence that the reflex increase in the heart rate following stimulation of the left atrial receptors is mediated by selective activation of cardiac sympathetic nerve fibres.4. The inhibitory effect of atrial receptor activation on the renal sympathetic nerve activity suggests that a neural factor, possibly involving renal haemodynamics, may be a component of the diuretic response to the activation of the left atrial receptors.5. The results provide further evidence for the selective nature of the pattern of reflex responses to left atrial receptor activation and show for the first time a directionally fractionated response from sympathetic efferent neurones.

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Section: Discussioncontrasting

confidence: 99%

The effects of stimulation of the left atrial receptors on sympathetic efferent nerve activity

Karim¹,

Kidd²,

Malpus³

et al. 1972

The Journal of Physiology

215

126

View full text Add to dashboard Cite

show abstract

“…Another explanation may be the occurrence of a local feedback inhibition by norepinephrine on alpha presynaptic receptors (20,21,25). The frequency of stimulation that produced the maximum catecholamine level in coronary sinus blood and the maximum intensity of cardiac responses was 10 Hz, a finding which is in agreement with previous reports on the optimum frequency of sympathetic nerve stimulation (26)(27)(28)(29).…”

Section: Figuresupporting

confidence: 90%

Correlation between the response of the heart to sympathetic stimulation and the release of endogenous catecholamines into the coronary sinus of the dog.

Yamaguchi¹,

Champlain²,

Nadeau³

1975

Circulation Research

144

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The relationship between the increase in catecholamine levels of the coronary sinus blood and the amplitude of various cardiac responses to adrenergic nerve stimulation was studied in anesthetized dogs. Plasma catecholamine levels in both coronary sinus and aortic blood were measured by a modification of the radiometric enzymatic assay for tissue catecholamines and were found to be 0.622 ± 0.104 (SE) ng/ml and 0.933 ± 0.116 ng/ml, respectively, under basal conditions. The catecholamine levels in coronary sinus blood increased linearly during right cardioaccelerator nerve stimulation up to a frequency of 10 Hz. At this frequency, maximum values were observed in both coronary sinus blood catecholamine levels and cardiac responses. The correlation between the response in heart rate, mean coronary blood flow, and dP/dt of left ventricular pressure and the increase in endogenous catecholamine levels of coronary sinus blood was significant, but the relationship was nonlinear. The present experimental design may prove to be a reliable means of studying the role of the sympathetic nervous system in the regulation of cardiovascular function in vivo. KEY WORDSplasma catecholamines dP/dt of left ventricular pressure heart rate stellate ganglion stimulation sympathetic fibers coronary blood flow• The release of norepinephrine from the heart in response to direct stimulation of sympathetic nerves has been reported previously, but attempts to correlate the amount of endogenous neurotransmitter liberated with the intensity of physiological responses in vivo have been limited (1-5). For instance, an overflow of endogenous norepinephrine produced by a short period of stimulation has never been demonstrated at very low stimulation frequencies despite the fact that most innervated tissues respond physiologically to a frequency range of 1 to 3 Hz (6). Moreover, in previous studies, multiple sampling of blood during short periods of stimulation has been prevented by the lack of sensitive, specific methods for the measurement of plasma catecholamines; as a result, accurate correlations with physiological responses have not been made.The recent development of radiometric enzymatic assay techniques has provided new means for the detection of small quantities of catecholamines (7-9). An adaptation of the assay for tissue This work was supported by grants from the Medical Research Council of Canada and the Quebec Heart Foundation.Received November 1, 1974. Accepted for publication February 27, 1975. catecholamines previously developed by Coyle and Henry (9) to plasma catecholamines allows changes in endogenous catecholamines released from the heart to be measured in a small volume of blood collected at short intervals from the coronary sinus; hence, catecholamine release can now be correlated with various parameters of the cardiac response following sympathetic nerve stimulation.The present report describes a close relationship between changes in endogenous catecholamine levels in coronary sinus blood and those in heart rate, ...

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“…Figure 2 is typical of the responses of the vessels in the occluded hind limb to sympathetic nerve stimulation. The arterial pressure rose rapidly, almost a square wave, the venous pressure somewhat more slowly; these changes have been fully documented elsewhere (Browse, Lorenz & Shepherd, 1966). The lymphatic pressure increased slowly, the rise beginning after 5-10 sec and reaching its asymptote in lf-2 min.…”

Section: Methodsmentioning

confidence: 55%

“…It has been shown in both the dog (Browse, Lorenz & Shepherd, 1966; and man (Samueloff et al 1966) that the venous volume remains constant below a suprasystolic occluding cuff. It is reasonable to assume that this is also true of lymphatic volume for these vessels do not communicate directly with either artery or vein.…”

Section: Discussionmentioning

confidence: 98%

Response of lymphatics of canine hind limb to sympathetic nerve stimulation

Browse¹

1968

The Journal of Physiology

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SUMMARY1. The changes in lymphatic pressure in a limb whose circulation was temporarily arrested with a pneumatic cuff have been studied.2. Stimulation of the lumbar sympathetic chain caused an increase in lymphatic pressure. It has been shown that this is a primary not a secondary phenomenon, due to an active lymphomotor mechanism.3. The increase of lymphatic tone is proportional to the rate of stimulation; peak values are reached between 5 and 9 impulses/sec.

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Response of capacity and resistance vessels of dog's limb to sympathetic nerve stimulation

Cited by 39 publications

References 0 publications

The effects of stimulation of the left atrial receptors on sympathetic efferent nerve activity

The effects of stimulation of the left atrial receptors on sympathetic efferent nerve activity

Correlation between the response of the heart to sympathetic stimulation and the release of endogenous catecholamines into the coronary sinus of the dog.

Response of lymphatics of canine hind limb to sympathetic nerve stimulation

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