Response of a Calcium Sulfate Bone Graft Substitute in a Confined Cancellous Defect

Walsh, William R.; Morberg, Per; Yu, Youcheng; Yang, Jing; Haggard, Warren O.; Sheath, P. C.; Svehla, M.; Bruce, Warwick

doi:10.1097/00003086-200301000-00033

Cited by 180 publications

(143 citation statements)

References 21 publications

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“…Some studies have shown that the degradation of CSD produced acidic degradable products and formed a local acidic microenvironment, which caused inflammatory reaction in vivo. 18,19 In this study, the pH of the solution decreased from 7.40 to 6.86 after the CSD cement immersion into PBS for 12 weeks, indicating that some acidic degradable products emerged during soaking. However, the pH of the solution for 20 nl-MSC slightly increased from 7.40 to 7.45, indicating that some basic products emerged after the degradation of nl-MS, which might neutralize the acidic degradable products of CSD.…”

mentioning

confidence: 57%

Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

Cao¹,

Weng²,

Chen³

et al. 2017

IJN

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Nanoporous lithium doping magnesium silicate (nl-MS) was introduced into calcium sulfate hemihydrate to prepare calcium sulfate composite (nl-MSC) bone cements. The introduction of nl-MS improved the in vitro degradability of nl-MSC cements, which could neutralize acidic degradable products of calcium sulfate and prevented the pH from dropping. The cements were implanted into the bone defects of femur bone of rabbits, and the results of histological and immunohistochemical analysis revealed that massive new bone tissue formed in the defects while the cements were degradable, indicating that the osteogenesis and degradability of the nl-MSC cements were much better than the control calcium sulfate dihydrate (CSD) cements. Furthermore, the positive expression of vascular endothelial growth factor and collagen type I for nl-MSC cements was higher than CSD, indicating that addition of nl-MS into the cements enhanced vascularization and osteogenic differentiation. The results suggested that the nl-MSC cements with good biocompatibility and degradability could promote vascularization and osteogenesis, and had great potential to treat bone defects.

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mentioning

confidence: 57%

Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

Cao¹,

Weng²,

Chen³

et al. 2017

IJN

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“…It is not biodegradable therefore a second operation is required for it to be removed once the antibiotic is released. If it is left in place, it will prevent bone ingrowth [6] and become a potential space for future infection [7].…”

Section: Discussionmentioning

confidence: 99%

A Case Report on the Treatment of Metcillin-Resistant Staphylococcus Aureus (Mrsa) Infected Tibial Internal Fixation with Calcium

Pillai¹

2015

Orthop Muscular Syst

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The formation of biofilm is one of the main contributing factors for unsuccessful treatment of osteomyelitis. It is formed through bacterial adhesion to the fragments of dead bone. Poor perfusion or devascularization of an infected bone with changes in local pH further limits the diffusion of parenteral antibiotics.Calcium Sulfate , a biocompatible and completely absorbable local carrier for antibiotics, has shown promising results in treating osteomyelitis. It is associated with less systemic effects and compliance issues when compared with conventional treatment of surgical debridement and prolonged systemic antibiotics.

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“…Lobenhoffer [12] et al retrospectively analyzed 26 cases sustaining unstable tibial plateau fractures. 25 cases were open reduction with plates and screws for fixation and one case was closed reduction.…”

Section: Synthetic Calcium Sulfate Cementmentioning

confidence: 99%

Treatment of Distal Radius Bone Defects with Injectable Calcium Sulphate Cement

Deng¹,

Zhanzhong²,

Huaikuo³

et al. 2012

Bone Grafting

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Response of a Calcium Sulfate Bone Graft Substitute in a Confined Cancellous Defect

Cited by 180 publications

References 21 publications

Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

A Case Report on the Treatment of Metcillin-Resistant Staphylococcus Aureus (Mrsa) Infected Tibial Internal Fixation with Calcium

Treatment of Distal Radius Bone Defects with Injectable Calcium Sulphate Cement

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