Response letter to Reviewer #2 (F. Anctil)

Abstract

The ambiguous representation of hydrological processes has led to the formulation of the multiple hypotheses approach in hydrological modeling, which requires new ways of model construction. However, most recent studies focus only on the comparison of predefined model structures or building a model step by step. This study tackles the problem the other way around: we start with one complex model structure, which includes all processes deemed to be important for the catchment. Next, we create 13 additional simplified models, where some of the processes from the starting structure are disabled. The performance of those models is evaluated using three objective functions (logarithmic Nash-Sutcliffe; percentage bias, PBIAS; and the ratio between the root mean square error and the standard deviation of the measured data). Through this incremental breakdown, we identify the most important processes and detect the restraining ones. This procedure allows constructing a more streamlined, subsequent 15th model with improved model performance, less uncertainty and higher model efficiency. We benchmark the original Model 1 and the final Model 15 with HBV Light. The final model is not able to outperform HBV Light, but we find that the incremental model breakdown leads to a structure with good model performance, fewer but more relevant processes and fewer model parameters.

Tratamento das metástases no esqueleto apendicular

“…As hastes ou placas devem ser longas, com o intuito de proteger todo o osso acometido. 13 14 O estudo de Narazaki et al 15 mostra que a sobrevida em pacientes tratados com haste intramedular sem cimento ósseo, por serem cirurgias menos mordidas, foi maior do que a dos tratados com endoprótese.…”

“…Além disso, outra recomendação para não usar a prótese sem cimento é que o uso de radioterapia de forma adjuvante no pós-operatório impede a fixação da prótese, impedindo o crescimento do osso ao redor desta e, consequentemente, sua fixação. 13 14…”

“…O uso de drenos é necessário em decorrência da magnitude cirúrgica e dos efeitos de medicamentos, especialmente cardíacos, que tornam o sangramento pós-operatório maior e aumentam o risco de infecção. 13 14…”

“…O pior cenário ocorre em áreas nas quais houve aplicação de radioterapia, ou em vigência de efeitos de quimioterápicos ou imunoterápicos, estes podem ser determinantes na necrose tecidual, caso ocorra, os tratamentos com curativos a vácuo são indicados. 13 14…”

“…The rods or plates should be long in order to protect all the affected bone. 13 14 A study by Narazaki et al 15 shows that survival in patients treated with intramedullary nail without bone cement had a better survival than those treated with endoprostheses, because they were less bitten surgeries.…”