Response latencies in the tail-flick test depend on tail skin temperature

Berge, Odd‐Geir; Garcia-Cabrera, Inmaculada; Hole, Kjell

doi:10.1016/0304-3940(88)90497-1

Cited by 155 publications

(46 citation statements)

References 14 publications

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“…Changes in basal glass temperature could potentially alter withdrawal latency. This has been demonstrated in the tail flick test where decreases in basal tail skin temperature increased tail flick latencies (Berge et al, 1988). Accordingly, failure to control glass temperature could lead to sources of random variation.…”

Section: Introductionmentioning

confidence: 94%

Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli

Dirig

Salami

Rathbun

et al. 1997

Journal of Neuroscience Methods

227

130

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Section: Introductionmentioning

confidence: 94%

Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli

Dirig

Salami

Rathbun

et al. 1997

Journal of Neuroscience Methods

227

130

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“…A possible pitfall in TIT might be related to the role of the tail in the thermoregulation of rodents 26,37 . As ambient temperature is a key factor in nociceptive response variations, it should be kept constant (here at 21 °C) throughout experiments 38 .…”

Section: Set Up Of Tit Operational Windowmentioning

confidence: 99%

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Elhabazi¹,

Ayachi²,

Ilien³

et al. 2014

JoVE

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Opioid-induced hyperalgesia and tolerance severely impact the clinical efficacy of opiates as pain relievers in animals and humans. The molecular mechanisms underlying both phenomena are not well understood and their elucidation should benefit from the study of animal models and from the design of appropriate experimental protocols.We describe here a methodological approach for inducing, recording and quantifying morphine-induced hyperalgesia as well as for evidencing analgesic tolerance, using the tail-immersion and tail pressure tests in wild-type mice. As shown in the video, the protocol is divided into five sequential steps. Handling and habituation phases allow a safe determination of the basal nociceptive response of the animals. Chronic morphine administration induces significant hyperalgesia as shown by an increase in both thermal and mechanical sensitivity, whereas the comparison of analgesia time-courses after acute or repeated morphine treatment clearly indicates the development of tolerance manifested by a decline in analgesic response amplitude. This protocol may be similarly adapted to genetically modified mice in order to evaluate the role of individual genes in the modulation of nociception and morphine analgesia. It also provides a model system to investigate the effectiveness of potential therapeutic agents to improve opiate analgesic efficacy.

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“…The potential effect of tail skin temperature on tail flick latency needs to be considered when tail flick latency is used as a test of nociception (Berge et al, 1988). It has been shown recently by our laboratory that reperfusion hyperalgesia is not influenced by tail skin temperature changes induced by ischaemia (Gelgor et al, 1992a).…”

Section: Tests Of Nociceptionmentioning

confidence: 99%

Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines

Cartmell

Mitchell

1993

British J Pharmacology

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1 An investigation into whether reperfusion hyperalgesia is modulated by prior systemic administration of two benzodiazepine agonists (diazepam and chlordiazepoxide), and an antagonist (flumazenil) was conducted. 2 Transient ischaemia was induced in conscious rats by applying an inflatable tourniquet to the base of the tail; when the rats exhibited a co-ordinated escape response, the tourniquet was deflated and reperfusion of the tail was allowed. Reperfusion hyperalgesia manifested as a decrease in tail flick latency, following tail immersion in 49'C water, after the release of the tourniquet. 3 Intraperitoneal administration of diazepam, chlordiazepoxide and flumazenil had no effect on the co-ordinated escape to the noxious ischaemic stimulus nor on tail flick latency after application of a sham tourniquet. 4 The hyperalgesia evident during reperfusion, was abolished by diazepam (1 and 5 mg kg-') and chlordiazepoxide (5 and 25 mg kg-'). The antihyperalgesic effects of both diazepam (5 mg kg-') and chlordiazepoxide (25 mg kg-) were inhibited by flumazenil (1 mg kg-'). 5 Rotarod performance was impaired in rats given diazepam and chlordiazepoxide at the same doses at which the benzodiazepines were antihyperalgesic. The impairment to motor function did not extend to the motor systems involved in the tail flick response. 6 In conclusion, benzodiazepines have antinociceptive properties during hyperalgesia.

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Response latencies in the tail-flick test depend on tail skin temperature

Cited by 155 publications

References 14 publications

Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli

Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines

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